COMLEX LEVEL 1 EXAM QUESTIONS AND
ANSWERS LATEST 2025-2026 UPDATE
fibrosarcoma - Answer-malignant fibroblasts within a collagenous
matrix
chondrosarcoma - Answer-osseous sarcomas that affect older patients
and has a predilection for flat bones in the *shoulders and pelvis*
tyrosine, due to a defect in phenylalanine hydroxylase - Answer-PKU
presents as failure to thrive, mental retardation, gapped teeth, etc. What
is the amino acid that needs to be supplemented due to a defect in what
enzyme?
Rib 2 - Answer-where does the posterior scalene attach to?
Paclitaxel - Answer-used in the treatment of breast and ovarian cancer
MOA: hyper stabilization of polymerized microtubules--> prevents the
breakdown of the mitotic spindle
restrictive barrier - Answer-maximum distance a patient can actually
move a joint, can be pathologic
, narcissistic personality disorder - Answer-patterns of grandiosity, need
for admiration, lack of empathy for others
A carotid massage causes an increase in stretch of the carotid
baroreceptors which causes a reflexive PARASYM response which
slows down the conduction velocity through the AV node this slowing
down Heart Rate--> used in paroxysmal supra ventricular tachycardia -
Answer-what does a carotid massage do and how does it affect the AV
node?
Chronic myelogenous leukemia t(9;22)--> Philly chx - Answer-a form
of leukemia characterized by the accumulation of abnormal, mature
granulocytes (granulocytes are a type of white blood cell), mild anemia,
thrombocytosis and basophilia. What is the associated chromosomal
translocation?
Burkitt's lymphoma t(8;14) - Answer-germinal B celll lymphoma that is
associated with a translocation between c-MYC and the Ig heavy chain
on which two chromosomes? It is endemic in the continent of Africa
which produces this
follicular lymphoma t(14;18) - Answer-second most common
lymphoma in the US, arises from germinal center B-cells. Presents with
painless peripheral lymphadenopathy w/ a history of lymph node
enlargement . Positive for CD 10, CD 19 and CD 20 expression. Results
in what chromosomal translocation evolving the BCL-2 gene?
,Acute promyelocytic leukemia t(15;17) - Answer-PML/RARA fusion
gene
associated with DIC, characteristic folded, bilobed nuclei are found in
these certain type of cells. Coarse azurorophilic granules and multiple
Auer rods are also present on histo
Clopidogrel - Answer-inhibits platelet aggregation by irreversibly
blocking the P2Y12 component of ADP receptors
Bacillus anthracis, tendonopathy - Answer-textile industry worker that
develops a low-grade fever, non-productive cough and substernal chest
pain have what bug? Treatment is with a fluroquinolone and why are
frequently associated with what ADR?
G-6-PD deficiency - Answer-X-linked recessive disorder present in
AAs and Mediterraneans that cause an inability to generate reduced
glutathione and lead to acute hemolysis when stress occurs. You will see
bite cells and Heinz bodies on peripheral blood smear.
Itranuclear opthalmoplegia - Answer-seen in those with MS, causes
impaired horizontal eye movement w/ weak adduction of the affected
eye and abduction nystagmus of the contralateral eye. Due to a lesion in
the MLF in the dorsomedial brainstem tegmentum of wither the pons or
the midbrain
lead poisoning - Answer-causes lethargy, seizures, or coma--> can also
develop distal motor neuropathies.
, -leads to denaturation of the enzyme ribonuclease which causes
ribosomes to persist in the the RBCs and lead to basophilic stippling
myofasical release, BLT, FPR, counterstain - Answer-what are indirect
OMM techniques?
Articulatory technique - Answer-OMM technique classified as low
velocity, moderate to high amplitude
pericarditis - Answer-EKG presents with PR depression, ST segment
elevation and PR elevation in lead II. They also have sharp, midsternal,
non-radiating chest pain and mild lethargy. What do they have?
Bottom rib in ISD/ Top rib in ESD - Answer-BITE mnemonic is used
for rib dysfunction treatments, what is it?
pectoralis minor muscle - Answer-what muscle connects to ribs 3-5?
rib dysfunctions are named by where they are stuck while rib
restrictions are named by which motion they do not experience! -
Answer-how are rib dysfunctions named and how do they differ from rib
restrictions?
decreases due to decreased transport - Answer-In Wilson's disease there
is a decrease in copper exportation which results in low biliary copper,
what happens to the transport protein ceruloplasmin?
ANSWERS LATEST 2025-2026 UPDATE
fibrosarcoma - Answer-malignant fibroblasts within a collagenous
matrix
chondrosarcoma - Answer-osseous sarcomas that affect older patients
and has a predilection for flat bones in the *shoulders and pelvis*
tyrosine, due to a defect in phenylalanine hydroxylase - Answer-PKU
presents as failure to thrive, mental retardation, gapped teeth, etc. What
is the amino acid that needs to be supplemented due to a defect in what
enzyme?
Rib 2 - Answer-where does the posterior scalene attach to?
Paclitaxel - Answer-used in the treatment of breast and ovarian cancer
MOA: hyper stabilization of polymerized microtubules--> prevents the
breakdown of the mitotic spindle
restrictive barrier - Answer-maximum distance a patient can actually
move a joint, can be pathologic
, narcissistic personality disorder - Answer-patterns of grandiosity, need
for admiration, lack of empathy for others
A carotid massage causes an increase in stretch of the carotid
baroreceptors which causes a reflexive PARASYM response which
slows down the conduction velocity through the AV node this slowing
down Heart Rate--> used in paroxysmal supra ventricular tachycardia -
Answer-what does a carotid massage do and how does it affect the AV
node?
Chronic myelogenous leukemia t(9;22)--> Philly chx - Answer-a form
of leukemia characterized by the accumulation of abnormal, mature
granulocytes (granulocytes are a type of white blood cell), mild anemia,
thrombocytosis and basophilia. What is the associated chromosomal
translocation?
Burkitt's lymphoma t(8;14) - Answer-germinal B celll lymphoma that is
associated with a translocation between c-MYC and the Ig heavy chain
on which two chromosomes? It is endemic in the continent of Africa
which produces this
follicular lymphoma t(14;18) - Answer-second most common
lymphoma in the US, arises from germinal center B-cells. Presents with
painless peripheral lymphadenopathy w/ a history of lymph node
enlargement . Positive for CD 10, CD 19 and CD 20 expression. Results
in what chromosomal translocation evolving the BCL-2 gene?
,Acute promyelocytic leukemia t(15;17) - Answer-PML/RARA fusion
gene
associated with DIC, characteristic folded, bilobed nuclei are found in
these certain type of cells. Coarse azurorophilic granules and multiple
Auer rods are also present on histo
Clopidogrel - Answer-inhibits platelet aggregation by irreversibly
blocking the P2Y12 component of ADP receptors
Bacillus anthracis, tendonopathy - Answer-textile industry worker that
develops a low-grade fever, non-productive cough and substernal chest
pain have what bug? Treatment is with a fluroquinolone and why are
frequently associated with what ADR?
G-6-PD deficiency - Answer-X-linked recessive disorder present in
AAs and Mediterraneans that cause an inability to generate reduced
glutathione and lead to acute hemolysis when stress occurs. You will see
bite cells and Heinz bodies on peripheral blood smear.
Itranuclear opthalmoplegia - Answer-seen in those with MS, causes
impaired horizontal eye movement w/ weak adduction of the affected
eye and abduction nystagmus of the contralateral eye. Due to a lesion in
the MLF in the dorsomedial brainstem tegmentum of wither the pons or
the midbrain
lead poisoning - Answer-causes lethargy, seizures, or coma--> can also
develop distal motor neuropathies.
, -leads to denaturation of the enzyme ribonuclease which causes
ribosomes to persist in the the RBCs and lead to basophilic stippling
myofasical release, BLT, FPR, counterstain - Answer-what are indirect
OMM techniques?
Articulatory technique - Answer-OMM technique classified as low
velocity, moderate to high amplitude
pericarditis - Answer-EKG presents with PR depression, ST segment
elevation and PR elevation in lead II. They also have sharp, midsternal,
non-radiating chest pain and mild lethargy. What do they have?
Bottom rib in ISD/ Top rib in ESD - Answer-BITE mnemonic is used
for rib dysfunction treatments, what is it?
pectoralis minor muscle - Answer-what muscle connects to ribs 3-5?
rib dysfunctions are named by where they are stuck while rib
restrictions are named by which motion they do not experience! -
Answer-how are rib dysfunctions named and how do they differ from rib
restrictions?
decreases due to decreased transport - Answer-In Wilson's disease there
is a decrease in copper exportation which results in low biliary copper,
what happens to the transport protein ceruloplasmin?
