1|Page
EVOLVE HESI PHARMACOLOGY EXAM ASSESSMENT
TESTBANK| ACTUAL Qs &As WITH
RATIONALES|LATEST UPDATE 2025/2026|ALREADY
GRADED A+
A client who has been taking phenazopyridine (Pyridium) for symptoms of
urethritis and cystitis comes to the clinic because her urine is reddish-orange.
Which question should the practical nurse ask to determine if the medication has
been effective?
A) How much water have you been drinking each day?
B) Does the urine color stain your toilet bowl or undergarments?
C) Have you had any relief from urinary pain, burning, or urgency?
D) Did your urine appear cloudy or have a foul odor on voiding? - (answers)C)
Have you had any relief from urinary pain, burning, or urgency?
Feedback:
Phenazopyridine, an over-the-counter urinary analgesic, acts on the mucosa of
the urinary tract to relieve urinary pain, burning, itching, or urgency (C) associated
with urethritis and cystitis. Although determining if the client is forcing fluids (A),
experiencing staining from Pyridium's side effect (B), or having signs of a urinary
infection (D) are worthwhile assessments, the therapeutic response of Pyridium is
related to urinary discomforts only.
A male client who has been receiving an antineoplastic drug has developed
thrombocytopenia. What instructions should the practical nurse (PN) reinforce?
A) Use suppository form of drugs.
B) Avoid large public gatherings.
C) Rise slowly when standing up.
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D) Shave with an electric razor. - (answers)D) Shave with an electric razor.
Feedback:
Thrombocytopenia is a common side effect of bone marrow depression caused by
several antineoplastic agents. The client is experiencing a low platelet count and
should use an electric razor (D) to reduce his risk of bleeding. (A, B, and C) are not
indicated for a client who needs to implement thrombocytopenia precautions.
The practical nurse (PN) is caring for a client who has been taking prednisone
(Deltasone) daily for a year. Which adverse effect should the PN document in the
client's record?
A) Photosensitvity.
B) Weight gain.
C) Loss of hair.
D) Pale skin color. - (answers)B) Weight gain.
Feedback:
Long term use of prednisone causes fluid retention and redistribution of fat
deposition. Weight gain (B) and moon face reflect adverse effects of long-term
prednisone use and should be documented. (A, C, and D) do not occur with
treatment using prednisone.
A female client with recurring headaches tells the practical nurse (PN) that she
has been taking at least 4 grams of acetaminophen a day. Which laboratory
studies should the PN review for this client?
A) Creatinine clearance.
B) Hepatic enzymes.
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C) Coagulation values.
D) Arterial blood gases. - (answers)B) Hepatic enzymes.
Feedback:
Liver toxicity can occur when doses of acetaminophen exceed 4 grams a day,
resulting in an elevation in hepatic enzyme values (B). (A, C, and D) do not reveal
findings related to acetaminophen toxicity.
A client receives a prescription for an oral opioid analgesic for post-operative
pain. Which adverse effect should the practical nurse (PN) monitor for with the
client?
A) Constipation.
B) Photosensitivity.
C) Decreased heart rate.
D) Frequent urination. - (answers)A) Constipation.
Feedback:
Opioid analgesics slow peristalsis, which leads to constipation (A), a common side
effect of opiates. (B, C, and D) are not associated with opioid analgesics.
Which action should the practical nurse implement when administering a buccal
medication?
A) Encourage the client to swallow.
B) Administer water with medication.
C) Ensure the medication is positioned under the tongue.
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D) Place the medication between the upper molar teeth and cheek. - (answers)D)
Place the medication between the upper molar teeth and cheek.
Feedback:
Buccal medications are placed between the upper molar teeth and the cheek (D)
for absorption by the capillaries of the oral mucosa. The client should be
cautioned against swallowing, not (A). Buccal medications are not administered
with water (B). (C) describes sublingual administration.
What assessment is most important for the practical nurse (PN) to obtain prior to
initiating medication therapy with phenelzine (Nardil) for a client with
depression?
A) Activity level.
B) Mood and affect.
C) Understanding of diet modification.
D) The client's support system. - (answers)C) Understanding of diet modification.
Feedback:
To prevent a potentially lethal hypertensive crisis, a tyramine-free diet should be
maintained during antidepressant therapy with Nardil, a monoamine oxidase
inhibitor (MAOI). It is most important to determine if the client understands diet
modification (C) before Nardil is initiated to prevent consumption of foods that
interact with Nardil. Although a client's activity level (A) and mood and affect (B)
should be monitored during antidepressant therapy, it is most important that the
client understand diet modifications. The client's support system (D) and network
of family and friends is important, but the client should understand the
responsibility of dietary compliance with the medication regimen.
EVOLVE HESI PHARMACOLOGY EXAM ASSESSMENT
TESTBANK| ACTUAL Qs &As WITH
RATIONALES|LATEST UPDATE 2025/2026|ALREADY
GRADED A+
A client who has been taking phenazopyridine (Pyridium) for symptoms of
urethritis and cystitis comes to the clinic because her urine is reddish-orange.
Which question should the practical nurse ask to determine if the medication has
been effective?
A) How much water have you been drinking each day?
B) Does the urine color stain your toilet bowl or undergarments?
C) Have you had any relief from urinary pain, burning, or urgency?
D) Did your urine appear cloudy or have a foul odor on voiding? - (answers)C)
Have you had any relief from urinary pain, burning, or urgency?
Feedback:
Phenazopyridine, an over-the-counter urinary analgesic, acts on the mucosa of
the urinary tract to relieve urinary pain, burning, itching, or urgency (C) associated
with urethritis and cystitis. Although determining if the client is forcing fluids (A),
experiencing staining from Pyridium's side effect (B), or having signs of a urinary
infection (D) are worthwhile assessments, the therapeutic response of Pyridium is
related to urinary discomforts only.
A male client who has been receiving an antineoplastic drug has developed
thrombocytopenia. What instructions should the practical nurse (PN) reinforce?
A) Use suppository form of drugs.
B) Avoid large public gatherings.
C) Rise slowly when standing up.
,2|Page
D) Shave with an electric razor. - (answers)D) Shave with an electric razor.
Feedback:
Thrombocytopenia is a common side effect of bone marrow depression caused by
several antineoplastic agents. The client is experiencing a low platelet count and
should use an electric razor (D) to reduce his risk of bleeding. (A, B, and C) are not
indicated for a client who needs to implement thrombocytopenia precautions.
The practical nurse (PN) is caring for a client who has been taking prednisone
(Deltasone) daily for a year. Which adverse effect should the PN document in the
client's record?
A) Photosensitvity.
B) Weight gain.
C) Loss of hair.
D) Pale skin color. - (answers)B) Weight gain.
Feedback:
Long term use of prednisone causes fluid retention and redistribution of fat
deposition. Weight gain (B) and moon face reflect adverse effects of long-term
prednisone use and should be documented. (A, C, and D) do not occur with
treatment using prednisone.
A female client with recurring headaches tells the practical nurse (PN) that she
has been taking at least 4 grams of acetaminophen a day. Which laboratory
studies should the PN review for this client?
A) Creatinine clearance.
B) Hepatic enzymes.
,3|Page
C) Coagulation values.
D) Arterial blood gases. - (answers)B) Hepatic enzymes.
Feedback:
Liver toxicity can occur when doses of acetaminophen exceed 4 grams a day,
resulting in an elevation in hepatic enzyme values (B). (A, C, and D) do not reveal
findings related to acetaminophen toxicity.
A client receives a prescription for an oral opioid analgesic for post-operative
pain. Which adverse effect should the practical nurse (PN) monitor for with the
client?
A) Constipation.
B) Photosensitivity.
C) Decreased heart rate.
D) Frequent urination. - (answers)A) Constipation.
Feedback:
Opioid analgesics slow peristalsis, which leads to constipation (A), a common side
effect of opiates. (B, C, and D) are not associated with opioid analgesics.
Which action should the practical nurse implement when administering a buccal
medication?
A) Encourage the client to swallow.
B) Administer water with medication.
C) Ensure the medication is positioned under the tongue.
, 4|Page
D) Place the medication between the upper molar teeth and cheek. - (answers)D)
Place the medication between the upper molar teeth and cheek.
Feedback:
Buccal medications are placed between the upper molar teeth and the cheek (D)
for absorption by the capillaries of the oral mucosa. The client should be
cautioned against swallowing, not (A). Buccal medications are not administered
with water (B). (C) describes sublingual administration.
What assessment is most important for the practical nurse (PN) to obtain prior to
initiating medication therapy with phenelzine (Nardil) for a client with
depression?
A) Activity level.
B) Mood and affect.
C) Understanding of diet modification.
D) The client's support system. - (answers)C) Understanding of diet modification.
Feedback:
To prevent a potentially lethal hypertensive crisis, a tyramine-free diet should be
maintained during antidepressant therapy with Nardil, a monoamine oxidase
inhibitor (MAOI). It is most important to determine if the client understands diet
modification (C) before Nardil is initiated to prevent consumption of foods that
interact with Nardil. Although a client's activity level (A) and mood and affect (B)
should be monitored during antidepressant therapy, it is most important that the
client understand diet modifications. The client's support system (D) and network
of family and friends is important, but the client should understand the
responsibility of dietary compliance with the medication regimen.
