TEST BANK Cellular and Molecular Immunology 10th
!| !| !| !| !| !|
Edition by Abul Abbas, Andrew Lichtman, and Shiv
!| !| !| !| !| !| !| !|
Pillai
!|
10th Edition
!|
PlusBay.Plus
,Table of Contents
!| !|
Chapter !|01 !|Properties !|and !|Overview !|o f !|Immune !|Responses 1
Chapter !|02 !|Cells !|and !|Tissues !|o f !|the !|Immune !|System 3
Chapter !|03 !|Leukocyte !|Circulation !|and !|Migration !|Into !|Tissues 6
Chapter !|04 !|Innate !|Immunity 10
Chapter !|05 !|Antibodies !|and !|Antigens 17
Chapter !|06 !|Antigen !|Presentation !|to !|T !|Lymphocytes !|and !|the !|Functions !|o f !|Major
Histocompatibility !|Complex !|Molecules 20
Chapter !|07 !|Immune !|Receptors !|and !|Signal !|Transduction 27
Chapter !|08 !|Lymphocyte !|Development !|and !|Antigen !|Receptor !|Gene !|Rearrangement 30
Chapter !|09 !|Activation !|of !|T !|Lymphocytes 34
Chapter !|10 !|Differentiation !|and !|Functions !|o f !|CD4+ !|Effector !|T !|Cells 38
Chapter !|11 !|Differentiation !|and !|Functions !|o f !|CD8+ !|Effector !|T !|Cells 42
Chapter !|12 !|B !|Cell !|Activation !|and !|Antibody !|Production 46
Chapter !|13 !|Effector !|Mechanisms !|o f !|Humoral !|Immunity 52
Chapter !|14 !|Specialized !|Immunity !|at !|Epithelial !|Barriers !|and !|in !|Immune !|Privileged !|Tissues 56
Chapter !|15 !|Immunologic !|Tolerance !|and !|Autoimmunity 62
Chapter !|16 !|Immunity !|to !|Microbes 67
Chapter !|17 !|Transplantation !|Immunology 72
Chapter !|18 !|Tumor !|Immunology 77
Chapter !|19 !|Hypersensitivity !|Disorders 81
Chapter !|20 !|Allergy 86
Chapter !|21 !|Primary !|and !|Acquired !|Immunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
!| !| !| !| !| !| !|
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
!| !| !| !| !| !| !| !| !|
MULTIPLE !|CHOICE
1. The !|principal !|function !|o f !|the !|immune !|system !|is:
a. Defense !|against !|cancer
b. Repair !|o f !|injured !|tissues
c. Defense !|against !|microbial !|infections
d. Prevention !|of !|inflammatory !|diseases
e. Protection !|against !|environmental !|toxins
ANS: ! | ! | C
The !|immune !|system !|has !|evolved !|in !|the !|setting !|of !|selective !|pressures !|imposed !|by !|microbial
!|infections. !|Although !|immune !|responses !|to !|cancer !|may !|occur, !|the !|concept !|that
!|“immunosurveillance” !|against !|cancer !|is !|a !|principal !|function !|of !|the !| immune !|system !|is
!|controversial. !|Repair !|of !|injured !|tissues !|may !|be !|a !|secondary !|consequence !|of !|the !|immune
!|responses !|and !|inflammation. !|Although !|the !|immune !|system !|has !|regulatory !|features !|that !|are
!|needed !|to !|prevent !|excessive !|inflammation, !|prevention !|of !|inflammatory !|diseases !|is !|not !|a
!|primary !|function. !|T he !|immune !|system !|can !|protect !|against !|microbial !|t oxins, !|but !|it !|generally
!|does !|not !|offer !|protection !|against !|toxins !|of !|nonbiologic !|origin.
2. Which !|o f !|the !|following !|infectious !|diseases !|was !|prevented !|by !|t he !|first
!|successful !|vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: ! | ! | C
In !|1798, !|Edward !|Jenner !|reported !|the !|first !|intentional !|successful !|vaccination, !|which !|was
!|against !|smallpox !|in !|a !|boy, !|using !|material !|from !|t he !|cowpox !|pustules !|o f !|a !|milkmaid. !|I n
!|1980, !|smallpox !|was !|reported !|to !|be !|eradicated !|worldwide !|by !|a !|vaccination !|program.
!|Effective !|vaccines !|against !|tetanus !|toxin, !|rubella !| virus, !|and !|poliovirus !|were !|developed !|in
!|the !|20th !|century !|and !|are !|widely !|used. !|There !|is !|no !|effective !|vaccine !|against
!|Mycobacterium !|tuberculosis.
3. Which !|of !|the !|following !|is !|a !|unique !|property !|o f !|the !|adaptive !|immune !|system?
a. Highly !|diverse !|repertoire !|of !|specificities !|for !|antigens
b. Self-nonself !|discrimination
c. Recognition !|o f !|microbial !|structures !|by !|both !|cell-associated !|and !|soluble !|receptors
d. Protection !|against !|viral !|infections
e. Responses !|that !|have !|the !|same !|kinetics !|and !|magnitude !|on !|repeated !|exposure !|to
!|t he !|same !|microbe
ANS: ! | ! | A
PlusBay.Plus
, Highly !|diverse !|repertoires !|of !|specificities !|for !|antigens !|are !|found !|only !|in !|T !|and !|B
!|lymphocytes, !|which !|are !|the !|central !|cellular !|components !|of !|the !|adaptive !|immune !|system.
!|Both !|t he !|innate !|and !|t he !|adaptive !|immune !|systems !|use !|cell-associated !|and !|soluble
!|receptors !|to !|recognize !|microbes, !|display !|some !|degree !|of !|self-nonself !|discrimination, !|and
!|protect !|against !|viruses. !|On !|repeated !|exposure !|to !|the !|same !|microbe, !|the !|adaptive !|immune
!|response !|becomes !|more !|rapid !|and !|of !|greater !|magnitude; !|this !|is !|the !|manifestation !|of
!|memory.
4. Antibodies !|and !|T !|lymphocytes !|are !|the !|respective !|mediators !|o f !|which !|two !|t ypes
!|o f !|immunity?
a. Innate !|and !|adaptive
b. Passive !|and !|active
c. Specific !|and !|nonspecific
d. Humoral!|and !|cell-mediated
e. Adult !|and !|neonatal
ANS: ! | ! | D
Both !|B !|and !|T !|lymphocytes !|are !|principal !|components !|of !|adaptive !|immunity. !|B
!|lymphocytes !|produce !|antibodies, !|which !|are !|the !|recognition !|and !|effector !|molecules !|of
!|humoral !|immune !|responses !|to !|extracellular !|pathogens. !|T !|cells !|recognize !|and !|promote
!|eradication !|of !|intracellular !|pathogens !|in !|cell-mediated !|immunity. !|Passive !|and !|active
!|immunity !|both !|can !|be !|mediated !|by !|either !|B !|or !|T !|lymphocytes. !|Specific !|immunity !|is
!|another !|term !|for !|adaptive !|immunity. !|Both !|B !|and !|T !|lymphocytes !|participate !|in !|adult
!|adaptive !|immunity !|but !|are !|still !|developing !|in !|the !|neonatal !|period.
5. The !|two !|major !|functional !|classes !|o f !|effector !|T !|lymphocytes !|are:
a. Helper !|T !|lymphocytes !|and !|cytotoxic !|T !|lymphocytes
b. Natural !|killer !|cells !|and !|cytoWtoWxW
ic.TTlBymSMph.oW cyStes
c. Memory !|T !|cells !|and !|effector !|T !|cells
d. Helper !|cells !|and !|antigen-presenting !|cells
e. Cytotoxic !|T !|lymphocytes !|and !|target !|cells
ANS: ! | ! | A
T !|cells !|can !|be !|classified !|into !|effector !|subsets !|t hat !|perform !|different !|effector !|functions.
!|Most !|effector !|T !|cells !|are !|either !|helper !|T !|lymphocytes, !|which !|enhance !|the !|responses !|of
!|other !|immune !|cells, !|including !|phagocytes !|and !|B !|cells, !|to !|infections, !|or !|cytotoxic !|T
!|lymphocytes, !|which !|directly !|kill !|infected !|cells. !|Natural !|killer !|cells !|are !|not !|T
!|lymphocytes.
Antigen-presenting !|cells !|usually !|are !|not !|T !|cells. !|Memory !|T !|cells !|are !|not !|effector !|T !|cells.
6. Which !|o f !|the !|following !|cell !|t ypes !|is !|required !|for !|all !|adaptive !|humoral !|immune !|responses?
a. Natural !|killer !|cells
b. Dendritic !|cells
c. Cytolytic !|T !|lymphocytes
d. B !|lymphocytes
e. Helper !|T !|lymphocytes
ANS: ! | ! | D
Humoral !|immune !|responses !|are !|antibody-mediated !|immune !|responses, !|and !|all !|antibodies
!|are !|made !|by !|B !|lymphocytes !|and !|no !|other !|cell !|type.
PlusBay.Plus
!| !| !| !| !| !|
Edition by Abul Abbas, Andrew Lichtman, and Shiv
!| !| !| !| !| !| !| !|
Pillai
!|
10th Edition
!|
PlusBay.Plus
,Table of Contents
!| !|
Chapter !|01 !|Properties !|and !|Overview !|o f !|Immune !|Responses 1
Chapter !|02 !|Cells !|and !|Tissues !|o f !|the !|Immune !|System 3
Chapter !|03 !|Leukocyte !|Circulation !|and !|Migration !|Into !|Tissues 6
Chapter !|04 !|Innate !|Immunity 10
Chapter !|05 !|Antibodies !|and !|Antigens 17
Chapter !|06 !|Antigen !|Presentation !|to !|T !|Lymphocytes !|and !|the !|Functions !|o f !|Major
Histocompatibility !|Complex !|Molecules 20
Chapter !|07 !|Immune !|Receptors !|and !|Signal !|Transduction 27
Chapter !|08 !|Lymphocyte !|Development !|and !|Antigen !|Receptor !|Gene !|Rearrangement 30
Chapter !|09 !|Activation !|of !|T !|Lymphocytes 34
Chapter !|10 !|Differentiation !|and !|Functions !|o f !|CD4+ !|Effector !|T !|Cells 38
Chapter !|11 !|Differentiation !|and !|Functions !|o f !|CD8+ !|Effector !|T !|Cells 42
Chapter !|12 !|B !|Cell !|Activation !|and !|Antibody !|Production 46
Chapter !|13 !|Effector !|Mechanisms !|o f !|Humoral !|Immunity 52
Chapter !|14 !|Specialized !|Immunity !|at !|Epithelial !|Barriers !|and !|in !|Immune !|Privileged !|Tissues 56
Chapter !|15 !|Immunologic !|Tolerance !|and !|Autoimmunity 62
Chapter !|16 !|Immunity !|to !|Microbes 67
Chapter !|17 !|Transplantation !|Immunology 72
Chapter !|18 !|Tumor !|Immunology 77
Chapter !|19 !|Hypersensitivity !|Disorders 81
Chapter !|20 !|Allergy 86
Chapter !|21 !|Primary !|and !|Acquired !|Immunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
!| !| !| !| !| !| !|
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
!| !| !| !| !| !| !| !| !|
MULTIPLE !|CHOICE
1. The !|principal !|function !|o f !|the !|immune !|system !|is:
a. Defense !|against !|cancer
b. Repair !|o f !|injured !|tissues
c. Defense !|against !|microbial !|infections
d. Prevention !|of !|inflammatory !|diseases
e. Protection !|against !|environmental !|toxins
ANS: ! | ! | C
The !|immune !|system !|has !|evolved !|in !|the !|setting !|of !|selective !|pressures !|imposed !|by !|microbial
!|infections. !|Although !|immune !|responses !|to !|cancer !|may !|occur, !|the !|concept !|that
!|“immunosurveillance” !|against !|cancer !|is !|a !|principal !|function !|of !|the !| immune !|system !|is
!|controversial. !|Repair !|of !|injured !|tissues !|may !|be !|a !|secondary !|consequence !|of !|the !|immune
!|responses !|and !|inflammation. !|Although !|the !|immune !|system !|has !|regulatory !|features !|that !|are
!|needed !|to !|prevent !|excessive !|inflammation, !|prevention !|of !|inflammatory !|diseases !|is !|not !|a
!|primary !|function. !|T he !|immune !|system !|can !|protect !|against !|microbial !|t oxins, !|but !|it !|generally
!|does !|not !|offer !|protection !|against !|toxins !|of !|nonbiologic !|origin.
2. Which !|o f !|the !|following !|infectious !|diseases !|was !|prevented !|by !|t he !|first
!|successful !|vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: ! | ! | C
In !|1798, !|Edward !|Jenner !|reported !|the !|first !|intentional !|successful !|vaccination, !|which !|was
!|against !|smallpox !|in !|a !|boy, !|using !|material !|from !|t he !|cowpox !|pustules !|o f !|a !|milkmaid. !|I n
!|1980, !|smallpox !|was !|reported !|to !|be !|eradicated !|worldwide !|by !|a !|vaccination !|program.
!|Effective !|vaccines !|against !|tetanus !|toxin, !|rubella !| virus, !|and !|poliovirus !|were !|developed !|in
!|the !|20th !|century !|and !|are !|widely !|used. !|There !|is !|no !|effective !|vaccine !|against
!|Mycobacterium !|tuberculosis.
3. Which !|of !|the !|following !|is !|a !|unique !|property !|o f !|the !|adaptive !|immune !|system?
a. Highly !|diverse !|repertoire !|of !|specificities !|for !|antigens
b. Self-nonself !|discrimination
c. Recognition !|o f !|microbial !|structures !|by !|both !|cell-associated !|and !|soluble !|receptors
d. Protection !|against !|viral !|infections
e. Responses !|that !|have !|the !|same !|kinetics !|and !|magnitude !|on !|repeated !|exposure !|to
!|t he !|same !|microbe
ANS: ! | ! | A
PlusBay.Plus
, Highly !|diverse !|repertoires !|of !|specificities !|for !|antigens !|are !|found !|only !|in !|T !|and !|B
!|lymphocytes, !|which !|are !|the !|central !|cellular !|components !|of !|the !|adaptive !|immune !|system.
!|Both !|t he !|innate !|and !|t he !|adaptive !|immune !|systems !|use !|cell-associated !|and !|soluble
!|receptors !|to !|recognize !|microbes, !|display !|some !|degree !|of !|self-nonself !|discrimination, !|and
!|protect !|against !|viruses. !|On !|repeated !|exposure !|to !|the !|same !|microbe, !|the !|adaptive !|immune
!|response !|becomes !|more !|rapid !|and !|of !|greater !|magnitude; !|this !|is !|the !|manifestation !|of
!|memory.
4. Antibodies !|and !|T !|lymphocytes !|are !|the !|respective !|mediators !|o f !|which !|two !|t ypes
!|o f !|immunity?
a. Innate !|and !|adaptive
b. Passive !|and !|active
c. Specific !|and !|nonspecific
d. Humoral!|and !|cell-mediated
e. Adult !|and !|neonatal
ANS: ! | ! | D
Both !|B !|and !|T !|lymphocytes !|are !|principal !|components !|of !|adaptive !|immunity. !|B
!|lymphocytes !|produce !|antibodies, !|which !|are !|the !|recognition !|and !|effector !|molecules !|of
!|humoral !|immune !|responses !|to !|extracellular !|pathogens. !|T !|cells !|recognize !|and !|promote
!|eradication !|of !|intracellular !|pathogens !|in !|cell-mediated !|immunity. !|Passive !|and !|active
!|immunity !|both !|can !|be !|mediated !|by !|either !|B !|or !|T !|lymphocytes. !|Specific !|immunity !|is
!|another !|term !|for !|adaptive !|immunity. !|Both !|B !|and !|T !|lymphocytes !|participate !|in !|adult
!|adaptive !|immunity !|but !|are !|still !|developing !|in !|the !|neonatal !|period.
5. The !|two !|major !|functional !|classes !|o f !|effector !|T !|lymphocytes !|are:
a. Helper !|T !|lymphocytes !|and !|cytotoxic !|T !|lymphocytes
b. Natural !|killer !|cells !|and !|cytoWtoWxW
ic.TTlBymSMph.oW cyStes
c. Memory !|T !|cells !|and !|effector !|T !|cells
d. Helper !|cells !|and !|antigen-presenting !|cells
e. Cytotoxic !|T !|lymphocytes !|and !|target !|cells
ANS: ! | ! | A
T !|cells !|can !|be !|classified !|into !|effector !|subsets !|t hat !|perform !|different !|effector !|functions.
!|Most !|effector !|T !|cells !|are !|either !|helper !|T !|lymphocytes, !|which !|enhance !|the !|responses !|of
!|other !|immune !|cells, !|including !|phagocytes !|and !|B !|cells, !|to !|infections, !|or !|cytotoxic !|T
!|lymphocytes, !|which !|directly !|kill !|infected !|cells. !|Natural !|killer !|cells !|are !|not !|T
!|lymphocytes.
Antigen-presenting !|cells !|usually !|are !|not !|T !|cells. !|Memory !|T !|cells !|are !|not !|effector !|T !|cells.
6. Which !|o f !|the !|following !|cell !|t ypes !|is !|required !|for !|all !|adaptive !|humoral !|immune !|responses?
a. Natural !|killer !|cells
b. Dendritic !|cells
c. Cytolytic !|T !|lymphocytes
d. B !|lymphocytes
e. Helper !|T !|lymphocytes
ANS: ! | ! | D
Humoral !|immune !|responses !|are !|antibody-mediated !|immune !|responses, !|and !|all !|antibodies
!|are !|made !|by !|B !|lymphocytes !|and !|no !|other !|cell !|type.
PlusBay.Plus
