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CLINICOPATHOLOGIC FOUNDATIONS OF
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MEDICINE 7TH EDITION ( WITH ANSWER
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KEY)
m
LATEST UPDATED EXAMINATION STUDY m m m m
GUIDE 2023
m m
GUARANTEED GRADE A+ m m
Chapter 1: Cell Adaptation, Injury and Death
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Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a resu
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1. of:
A) release of stored calcium from the mitochondria.
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B) improved intracellular volume regulation. m m m
C) decreased influx across the cell membrane. m m m m m
D) attraction of calcium to fatty infiltrates. m m m m m
The patient is found to have liver disease, resulting in the removal of a lobe of his liver.
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2. Adaptation to the reduced size of the liver leads to _
m m of the remaining liver cells.
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A) metaplasia
B) organ atrophy m
C) compensatory hyperplasia m
D) physiologic hypertrophy m
A person eating peanuts starts choking and collapses. His airway obstruction is partially
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mcleared, but he remains hypoxic until he reaches the hospital. The prolonged cell hypoxia
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3. caused a cerebral infarction and resulting
m m _ in the brain. m m m m m m
A) caspase activation m
B) coagulation necrosis m
C) rapid phagocytosis m
D) protein p53 deficiency m m
Bacteria and viruses cause cell damage by
m m m m m m , which is unique from the intracellular
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4. damage caused by other injurious agents.
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A) disrupting the sodium/potassium ATPase pump m m m m
B) interrupting oxidative metabolism processes m m m
C) replicating and producing continued injury m m m m
,TEST BANK FOR RUBIN’S PATHOLOGY:
m m m m m
CLINICOPATHOLOGIC FOUNDATIONS OF
m m m m
MEDICINE 7TH EDITION ( WITH ANSWER
m m m m m m m
KEY)
m
LATEST UPDATED EXAMINATION STUDY
m m m m
GUIDE 2023
m m
GUARANTEED GRADE A+ m m
D) decreasing protein synthesis and function
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The patient has a prolonged interruption in arterial blood flow to his left kidney, causing
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5. hypoxic cell injury and the release of free radicals. Free radicals damage cells by:
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A) destroying phospholipids in the cell membrane.
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B) altering the immune response of the cell.
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C) disrupting calcium storage in the cell.
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D) inactivation of enzymes and mitochondria.
m m m m
,TEST BANK FOR RUBIN’S PATHOLOGY:
m m m m m
CLINICOPATHOLOGIC FOUNDATIONS OF
m m m m
MEDICINE 7TH EDITION ( WITH ANSWER
m m m m m m m
KEY)
m
LATEST UPDATED EXAMINATION STUDY m m m m
GUIDE 2023
m m
GUARANTEED GRADE A+ m m
6. Injured cells have impaired flow of substances through the cell membrane as a result of:
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A) increased fat load. m m
B) altered permeability. m
C) altered glucose utilization.
m m
D) increased surface receptors. m m
7. Reversible adaptive intracellular responses are initiated by:
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A) stimulus overload. m
B) genetic mutations. m
C) chemical messengers. m
D) mitochondrial DNA. m
8. Injured cells become very swollen as a result of:
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A) increased cell protein synthesis. m m m
B) altered cell volume regulation.
m m m
C) passive entry of potassium into the cell.
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D) bleb formation in the plasma membrane.
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A diabetic patient has impaired sensation, circulation, and oxygenation of his feet. He steps
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mon a piece of glass, the wound does not heal, and the area tissue becomes necrotic. The
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mnecrotic
9. cell death is characterized by:
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A) rapid apoptosis.m
B) cellular rupture. m
C) shrinkage and collapse. m m
D) chronic inflammation. m
A 99-year-old woman has experienced the decline of cell function associated with age. A
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10. group of theories of cellular aging focus on programmed:
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A) changes with genetic influences.
m m m
B) elimination of cell receptor sites. m m m m
C) insufficient telomerase enzyme. m m
, TEST BANK FOR RUBIN’S PATHOLOGY:
m m m m m
CLINICOPATHOLOGIC FOUNDATIONS OF
m m m m
MEDICINE 7TH EDITION ( WITH ANSWER
m m m m m m m
KEY)
m
LATEST UPDATED EXAMINATION STUDY
m m m m
GUIDE 2023
m m
GUARANTEED GRADE A+ m m
D) DNA mutation or faulty repair.
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An 89-year-old female patient has experienced significant decreases in her mobility and
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mstamina during a 3-week hospital stay for the treatment of a femoral head fracture. Which
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mof the following phenomena most likely accounts for the patients decrease in muscle
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mfunction
11. that underlies her reduced mobility?
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A) Impaired muscle cell metabolism resulting from metaplasia
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B) Dysplasia as a consequence of inflammation during bone remodeling
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C) Disuse atrophy of muscle cells during a prolonged period of immobility
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