CPJE Top 400 Drugs & Doses UPDATED
ACTUAL Exam Questions and CORRECT
Answers
Tylenol - CORRECT ANSWER - Acetaminophen
I: fever/pain
D: 325-650mg, max < 4000mg/day from all sources
*OD = liver damage, use NAC for antidote
Ofirmev (IV) - CORRECT ANSWER - Acetaminophen
I: fever/pain
D: < 4000mg/day from all sources
*Can treat more severe pain
*OD = liver damage, use NAC for antidote
NAC - CORRECT ANSWER - N-acetylcysteine
I: APAP overdose
Bayer - CORRECT ANSWER - Aspirin
I: fever/pain/inflammation
D: 81-325mg qd
CI: pregnancy (esp 3rd trimester), OD = tinnitis
*BBW: COX-1 selectivity NSAID = GI bleed
Motrin, Advil - CORRECT ANSWER - Ibuprofen
I: fever/pain/inflammation
Dose
,-OTC: 200-400mg q 4-6 hrs
-Rx: 600-800 mg tid, max 3200mg/d
*BBW: COX-1 selectivity NSAID = GI bleed
Naprosyn - CORRECT ANSWER - Naproxen, Aleve
I: fever/pain/inflammation
D:
-OTC: 220mg qd
-Rx: 250-550mg bid
*Higher GI side effects
*BBW: COX-1 selectivity NSAID = GI bleed
Daypro - CORRECT ANSWER - Oxaprozin
I: fever/pain/inflammation
*Similar caution to piroxicam: high risk for GI tox and severe SJS
*BBW: COX-1 selectivity NSAID = GI bleed
Voltaren - CORRECT ANSWER - Diclofenac (gel)
I: pain/inflammation
Dose: AAA 2-4g QID
Toradol - CORRECT ANSWER - Ketorolac
I: analgesia
D:
-IV/IM 30mg x 1, or 30mg QID (max 120mg/d)
-PO: 20mg once after IV or IM, then 10mg q4-6hr (max: 40mg/d)
*Max = 5 days of treatment
*Most GI toxic w/ piroxicam
,*BBW: COX-1 selectivity NSAID = GI bleed
Indocin - CORRECT ANSWER - Indomethacin
-I: fever/pain/inflammation, gout
-D: 25-50mg IR, 75mg BID CR
*High risk for CNS SE and GI toxicity
*BBW: COX-1 selectivity NSAID = GI bleed
Clinoril - CORRECT ANSWER - Sulindac
*less common NSAID that may be better w/ reduced renal function
*BBW: COX-1 selectivity NSAID = GI bleed
Relafen - CORRECT ANSWER - Nabumetone
I: fever/pain/inflammation
D: 1000-200mg qd or bid
Feldene - CORRECT ANSWER - Piroxicam
I: fever/pain/inflammation
D: 10-20mg qd
*High risk for GI tox and severe SJS
*Most GI toxic w/ ketorolac
*BBW: COX-1 selectivity NSAID = GI bleed
Mobic - CORRECT ANSWER - Meloxicam
I: fever/pain/inflammation
D: 7.5-15mg po (Max: 15mg/d)
*COX-2 selectivity NSAID: CV event (MI, stroke)
, Celebrex - CORRECT ANSWER - Celecoxib
I: fever/pain/inflammation
D: 200mg qd or BID
*lowest GI bleed risk but highest CV risk
*COX-2 selectivity NSAID: CV event (MI, stroke)
Humira - CORRECT ANSWER - Adalimumab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 40mg SC every other week
*BBW: fatal infections, malignancy, TB
Remicade - CORRECT ANSWER - Infliximab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 3 mg/kg IV on weeks 0, 2 and 6, then q8w
*Delayed hypersensitivity reactions
*BBW: fatal infections, malignancy, TB
Enbrel - CORRECT ANSWER - Etanercept
I: arthritis, psoriasis, Crohn's, UC, etc
D: 50mg SC weekly
*BBW: fatal infections, malignancy, TB
Orencia - CORRECT ANSWER - Abatacept
I: arthritis
D: 500-1000mg IV at 0, 2 and 4 weeks, then qm, 125mg SC weekly
*NS only
*Warnings: malignancies, serious infections, may worsen COPD sx
ACTUAL Exam Questions and CORRECT
Answers
Tylenol - CORRECT ANSWER - Acetaminophen
I: fever/pain
D: 325-650mg, max < 4000mg/day from all sources
*OD = liver damage, use NAC for antidote
Ofirmev (IV) - CORRECT ANSWER - Acetaminophen
I: fever/pain
D: < 4000mg/day from all sources
*Can treat more severe pain
*OD = liver damage, use NAC for antidote
NAC - CORRECT ANSWER - N-acetylcysteine
I: APAP overdose
Bayer - CORRECT ANSWER - Aspirin
I: fever/pain/inflammation
D: 81-325mg qd
CI: pregnancy (esp 3rd trimester), OD = tinnitis
*BBW: COX-1 selectivity NSAID = GI bleed
Motrin, Advil - CORRECT ANSWER - Ibuprofen
I: fever/pain/inflammation
Dose
,-OTC: 200-400mg q 4-6 hrs
-Rx: 600-800 mg tid, max 3200mg/d
*BBW: COX-1 selectivity NSAID = GI bleed
Naprosyn - CORRECT ANSWER - Naproxen, Aleve
I: fever/pain/inflammation
D:
-OTC: 220mg qd
-Rx: 250-550mg bid
*Higher GI side effects
*BBW: COX-1 selectivity NSAID = GI bleed
Daypro - CORRECT ANSWER - Oxaprozin
I: fever/pain/inflammation
*Similar caution to piroxicam: high risk for GI tox and severe SJS
*BBW: COX-1 selectivity NSAID = GI bleed
Voltaren - CORRECT ANSWER - Diclofenac (gel)
I: pain/inflammation
Dose: AAA 2-4g QID
Toradol - CORRECT ANSWER - Ketorolac
I: analgesia
D:
-IV/IM 30mg x 1, or 30mg QID (max 120mg/d)
-PO: 20mg once after IV or IM, then 10mg q4-6hr (max: 40mg/d)
*Max = 5 days of treatment
*Most GI toxic w/ piroxicam
,*BBW: COX-1 selectivity NSAID = GI bleed
Indocin - CORRECT ANSWER - Indomethacin
-I: fever/pain/inflammation, gout
-D: 25-50mg IR, 75mg BID CR
*High risk for CNS SE and GI toxicity
*BBW: COX-1 selectivity NSAID = GI bleed
Clinoril - CORRECT ANSWER - Sulindac
*less common NSAID that may be better w/ reduced renal function
*BBW: COX-1 selectivity NSAID = GI bleed
Relafen - CORRECT ANSWER - Nabumetone
I: fever/pain/inflammation
D: 1000-200mg qd or bid
Feldene - CORRECT ANSWER - Piroxicam
I: fever/pain/inflammation
D: 10-20mg qd
*High risk for GI tox and severe SJS
*Most GI toxic w/ ketorolac
*BBW: COX-1 selectivity NSAID = GI bleed
Mobic - CORRECT ANSWER - Meloxicam
I: fever/pain/inflammation
D: 7.5-15mg po (Max: 15mg/d)
*COX-2 selectivity NSAID: CV event (MI, stroke)
, Celebrex - CORRECT ANSWER - Celecoxib
I: fever/pain/inflammation
D: 200mg qd or BID
*lowest GI bleed risk but highest CV risk
*COX-2 selectivity NSAID: CV event (MI, stroke)
Humira - CORRECT ANSWER - Adalimumab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 40mg SC every other week
*BBW: fatal infections, malignancy, TB
Remicade - CORRECT ANSWER - Infliximab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 3 mg/kg IV on weeks 0, 2 and 6, then q8w
*Delayed hypersensitivity reactions
*BBW: fatal infections, malignancy, TB
Enbrel - CORRECT ANSWER - Etanercept
I: arthritis, psoriasis, Crohn's, UC, etc
D: 50mg SC weekly
*BBW: fatal infections, malignancy, TB
Orencia - CORRECT ANSWER - Abatacept
I: arthritis
D: 500-1000mg IV at 0, 2 and 4 weeks, then qm, 125mg SC weekly
*NS only
*Warnings: malignancies, serious infections, may worsen COPD sx
