National Board of Medical Examiners (NBME)
NBME USMLE (United States Medical Licensing
Examination): USMLE Step 1, 2 and 3
NBME CBSSA & NBME CBSE Comprehensive Basic
Science Self- Assessment and Examination
Course Title and Number: NBME CBSSA, NBME CBSE, and
NBME USMLE Exam
Exam Title: NBME
Exam Date: Exam 2025- 2026
Instructor: ____ [Insert Instructor’s Name] _______
Student Name: ___ [Insert Student’s Name] _____
Student ID: ____ [Insert Student ID] _____________
Examination
Time: - ____ Hours: ___ Minutes
Instructions:
1. Read each question carefully.
2. Answer all questions.
3. Use the provided answer sheet to mark your responses.
4. Ensure all answers are final before submitting the exam.
5. Please answer each question below and click Submit when you
have completed the Exam.
6. This test has a time limit, The test will save and submit
automatically when the time expires
7. This is Exam which will assess your knowledge on the course
Learning Resources.
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USMLE Step 2 CK (Clinical Knowledge) NBME High Yield USMLE
United States Medical Licensing Examination Review Questions
and Answers | 100% Pass Guaranteed | Graded A+ |
2025- 2026
NBME USMLE (United States Medical Licensing Examination)
USMLE Step 1, Step 2 CK (Clinical Knowledge), Step 2 CS
(Clinical Skills - discontinued), & Step 3
NBME CBSSA & NBME CBSE Comprehensive Basic Science Self-
Assessment and Examination
National Board of Medical Examiners (NBME)
Read All Instructions Carefully and Answer All the
Questions Correctly Good Luck: -
Impaired fertility in a man and high riding bilateral mass. What
is the underlying cause? - =Answer>> Varicocele.
82 year old with decreased vision. Dilated veins, widespread
retinal hemorrhages intermixed with white plaques on
fundoscopic exam. Diagnosis? - =Answer>> Central retinal
vein artery occlusion.
15 year old girl she is on chronic steroid therapy. Now presents
with acute back pain. What is the most likely cause? -
=Answer>> Osteoporotic compression fracture.
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Patient with flank pain with radiation to the groin. He has
normal vital signs. Pain relieved with morphine. Next best step?
- =Answer>> Increase fluid discharge and send him home.
Terminal cancer patient that comes in with acute onset lower
back pain. She is taking morphine Q4 which works for a bit but
then subsides. What should you do to her regimen? -
=Answer>> Make the morphine Q3 so she has adequate
pain control.
A young infant that has bilateral retinal hemorrhages and tense
fontanelle. What is the most likely cause? - =Answer>>
Child abuse
What is the treatment for an acute gout attack? -
=Answer>> 1. NSAIDs: Indomethacin
2. Steroids
3. Colchicine
Patient who is sick in the ICU, and has (comatose level)
hypernatremia. She has a low urine specific gravity. Normal
kidney function. What is the underlying cause of
hypernatremia? - =Answer>> Diabetes Insipidus. She
cannot concentrate her urine.
4 year old boy. Suddenly develops a pancytopenia, has
hepatosplenomegaly and adenopathy. Some mild gingival
bleeding. Next best step? - =Answer>> Bone marrow
biopsy. This kid has ALL.
Patient has a first time positive PPD and a negative chest X-ray.
What is the next best step? - =Answer>> This patient has
latent TB. This means that he needs to be treated with INH for 9
months.
Furthermore, if he had a negative PPD. B/c this is his first time,
he would come back in two weeks.
Patient that is mute. Has bilateral nystagmus, hypertonia,
decreased sensation to skin prick. What is the most likely
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overdose? - =Answer>> Intoxication with PCP. Remember
he does not always have to be aggressive.
Patient has a family history of ovarian cancer. What is the best
thing to do if she is worried that she may get an ovarian
malignancy? - =Answer>> Put her on OCP. They prevent
risk of ovarian and endometrial cancer.
Elderly patient with increased ESR. Decreased hip motion, and
a 20 degree hip flexion contracture. What is the most likely
cause? - =Answer>> Osteoarthritis. Decrease in flexion of
115 degrees is diagnostic criteria. X-ray may show joint space
narrowing.
COPD patient that is post operative day 4 complains of
serosang discharge. PE shows abdominal distension, mild
tenderness to the incision, and no erythema. What is the most
likely diagnosis? - =Answer>> Wound dehiscence. Pestana
says a salmon colored discharge that SOAKS the dressing on
post-op day four.
A patient comes in with upper motor neuron signs along with
atrophy fasiculations and LMN signs. What will the EMG show? -
=Answer>> Fibrillation potentials in multiple sites of the
muscle. UpToDate: Fibrillation potentials occur when an
individual muscle fiber is denervated (eg, it is no longer
innervated by its nerve terminal). The denervated muscle fiber
spontaneously produces a muscle action potential, or fibrillation
potential.
Patient feels as if something is crawling on his skin. He has
visual hallucinations, and multiple excoriations on his face.
What is the urinary tox screen going to show? - =Answer>>
Amphetamines or cocaine. Remember this might be an opiate
withdrawal, however the question asks the urinary toxicology
screen.
A patient has a nine-pound baby, and continues to bleed.
Furthermore, the placenta comes out. It is torn, but intact.
What is the likely cause of increased bleeding? - =Answer>>
Uterine atony. Just had a huge baby.
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