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NR566-Advanced Pharmacology for Care of the Family 2024/2025 Exam Questions and Answers | A+ Score Assured

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NR566-Advanced Pharmacology for Care of the Family 2024/2025 Exam Questions and Answers | A+ Score Assured β-lactam antibiotic MOA -

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Advanced Pharmacology
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Advanced pharmacology











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Institution
Advanced pharmacology
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Advanced pharmacology

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Uploaded on
February 26, 2025
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Written in
2024/2025
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NR566-Advanced Pharmacology for
Care of the Family 2024/2025 Exam
Questions and Answers | A+ Score
Assured



β-lactam antibiotic MOA - 🧠ANSWER ✔✔All antibiotics in class share the

same mechanism of action: disruption of the bacterial cell wall.




Inhibition of cell wall synthesis


Empiric Therapy - 🧠ANSWER ✔✔start treatment without cultures or prior to

receiving the results of a culture


immediate empiric antibiotics - 🧠ANSWER ✔✔Critically ill patients receive

(Fill in the Answer) after the first set of cultures obtained; do not wait for

results.


Bactericidal antibiotics - 🧠ANSWER ✔✔Directly kill bacteria: Agents

include aminoglycosides, beta-lactams, fluoroquinolones, metronidazole,

most antimycobacterial agents, streptogramins, and vancomycin.



COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY 1
STATEMENT. ALL RIGHTS RESERVED

,preferred for immunocompromised patients such as those with diabetes,

HIV, or cancer and for those who have overwhelming infections


Bacteriostatic agents - 🧠ANSWER ✔✔inhibit bacterial proliferation while

the host's immune system does the killing. Agents include clindamycin,

macrolides, sulfonamides, and tetracyclines


β-lactam Antibiotics - 🧠ANSWER ✔✔Penicillins, Cephalosporins,

Carbapenems, Monobactams


Penicillins MOA - 🧠ANSWER ✔✔Weaken bacterial cell wall by two actions:


(1) inhibition of transpeptidases

(2) disinhibition (activation) of autolysins.


PBPs (Penicillin Binding Proteins) - 🧠ANSWER ✔✔Transpeptidases,

Autolysins, and other bacterial enzymes are collectively named as because

antibiotic class must bind to them to produce antibacterial effects.


gram-positive bacteria - 🧠ANSWER ✔✔two layers: the cytoplasmic

membrane and a relatively thick cell wall; penicillins are generally very

active against these organisms.



COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY 2
STATEMENT. ALL RIGHTS RESERVED

,gram-negative bacteria - 🧠ANSWER ✔✔three layers: the cytoplasmic

membrane, a relatively thin cell wall, and an additional outer membrane;

only certain penicillins (e.g., ampicillin) are able to cross and reach

penicillin binding proteins (PBPs)


Four Major Groups of Penicillins - 🧠ANSWER ✔✔(1) narrow-spectrum

penicillins that are penicillinase sensitive




(2) narrow-spectrum penicillins that are penicillinase resistant

(antistaphylococcal penicillins)




(3) broad-spectrum penicillins (aminopenicillins)




(4) extended-spectrum penicillins (antipseudomonal penicillins).

narrow-spectrum penicillins: Penicillinase sensitive penicillins - 🧠ANSWER

✔✔Penicillin G, Penicillin V


narrow-spectrum penicillinase sensitive susceptible pathogens -

🧠ANSWER ✔✔Streptococci, Neisseria, anaerobes



COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY 3
STATEMENT. ALL RIGHTS RESERVED

, very narrow antimicrobial spectrum and are used only against penicillinase-

producing strains of staphylococci (S. aureus and S. epidermidis). -

🧠ANSWER ✔✔narrow-spectrum penicillins: penicillinase resistant

penicillins

narrow-spectrum penicillins: penicillinase resistant penicillins - 🧠ANSWER

✔✔Nafcillin, Oxacillin, Dicloxacillin


narrow-spectrum- penicillinase resistant susceptible pathogens -

🧠ANSWER ✔✔S. Aureus, S. Epidermidis


Drugs of choice for most staphylococcal infections - 🧠ANSWER

✔✔penicillinase-resistant penicillins (Nafcillin, Oxacillin, Dicloxacillin)


Broad spectrum Penicillin: Aminopenicillins - 🧠ANSWER ✔✔Ampicillin,

Amoxicillin

Broad spectrum Aminopenicillin susceptible pathogens - 🧠ANSWER

✔✔Haemophilus influenzae, Escherichia coli, Proteus mirabilis,

enterococci, Neisseria gonorrhoeae

Extended spectrum penicillins (antipseudomonal penicillin) - 🧠ANSWER

✔✔Piperacillin




COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY 4
STATEMENT. ALL RIGHTS RESERVED

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