,BASIC IMMU N O LO G Y
k k
FunctionsandDisorders k k k
of the Immune System
k k k
F I F TH EDITION
k k
AbulkK. kAbbas, k MBBSkD is tingui
shedk Professork ink P athologyk Chair,k D e
partmentk ofk Pathologyk Univers ityk ofk C
aliforniak Sank Francis cok Sank Francis co,k
California
Andrewk H. k Lichtman, k MD, k PhD
Professork ofk Pathologyk Harvar
dk Medicalk School
Brighamkandk Women’s kHos pitalk Bos to
n,k Massachusetts
ShivkPillai, kMBBS, kPhD
ProfessorkofkM edicinek andk H ealthk Sciences k andk Technologyk H arva
rdk Medicalk S chool
RagonkInstitutekofk M ass achus etts k G eneralk Hos pital,k MIT kandkH arvardk Bos to
n,k Massachusetts
Illustrations k byk D avidk L.k Baker,k MAk A l
exandrak Baker,k MS,k CMI
DNA k Illustrations,k Inc.
,3251 k Riverportk Lane
St.k Louis, k Missourik 63043
BASICk IMMUNOLOGY:k FUNCTIONSk AND k D ISORD ERSk OF ISBN:k k 978-0-323-39082-8
THE k IMMUNE k SYSTEM, k Fifth k Edition
Copyright k©k20 16 kby kElsevier kInc. kAll krig ht skreserved.
Previous k editions k copyrighted k 2014,k 2011,k 2009,k 2006,k 2004,k and k 2001.
No k partk of k this k publication k may k bek reproduced kor k transmitted k in k any k formk or k byk any k means,k electron
ick or k mechanical, k includin gk photocopying, k recordin g, k or k any k information k storagek and k retrievalk syste
m,k withoutk permission k in k writingk from k thek publisher. k D etails k on k howk to k seek kpermission, k further k info
r-
k mation k aboutk thek Publisher’s k permissions k policies, k and k our k arrangements k with k organizations k such k as
k thek Copyrightk Clear ance k Center k and k thek Copyrightk Licensin gk Agency k can k bek found k atk our k website:k
www.elsevier.com/permissions .
This k book k andk thek individualk contributions k contained k in k itk arek protected k under k copyrightk by k thek Pub-
k lisher k (other k than k as k may k bek noted k herein).
Notices
Knowled gek and k bestk practicek in k this k field k arek constantly k changing. k As k newk research k andk experien
cek broaden k our k understanding, k changes k in k research k methods, k professionalk practices, k or k medicalk tr
eat- k mentk may k becomek necessary.
Practitioners k and k researchers k mustk always k rely k on k their k own k experiencek and k knowledgek in k eval
uatingk and k usingk any k information, k methods, k compounds,k or k experiments k described kherein. k In k usi
ngk such k information k or k methods k theyk shouldk bek mindfulk ofk their k own k safety k and k theksafety k of k ot
hers,k includingk parties k for k whom k they k havek ak professionalk responsibility.
With k respectk to k any k drugk or k pharmaceuticalk products k identified, k readers k arek advised k to k check k t
hek mostk currentk information k provided k (i)k on k procedures k featured k ork (ii) k by k thek manufacturer k of k e
ach k productk to k bek administered, k to k verify k thek recommended k dosek or kformula, k thek method k and k dur
ation k of k administration, k and k contraindications. k Itk is k thek responsibility k ofk practitioners, k relyingk on k
their k own k experiencek and k knowledgek of k their k patients, k to k makek diagnoses, k to k determinek dosages k
and k thek bestk treatmentk for k each k individualk patient, k and k to k takek allk appropriatek safety k precautions.
To k thek fullestk extentk of k thek law,k neither k thek Publisher k nor k thek authors, k contributors, k or k editorsk
assumek any k liability k for k any k injury k and/ork damagek to k persons k ork property k as k ak matter k of k products
k liability, k ne gligenc e k or k otherwise, k or k from k any kusek ork operation k of k anyk methods, k products, k instru
c- k tions,k or k ideas k contained k in k thek materialk herein.
Library k of k Congressk Cataloging-in-Publicatio nk Data
Abbas, k Abulk K.,k author.
Basick immunology k :k functions k and k disorders k of k thek immunek system k /k Abulk K.k Abbas, k Andrew
H.k Lichtman, k Shiv k Pillaik ;k Illustrations k by k D avid k L.k Baker,k Alexandrak Baker. k -- k Fifth k edition.
p.k ;k cm.
Includes kbibliographicalkreferences kand kindex.
k ISBNk 978-0-323-39082-8
I.k Lichtman, k Andrewk H.,k author. k II.k Pillai,k Shiv,k author. k III.k Title.
[ D NLM:k 1.k Immunity. k 2.k Hypersensitivity. k 3.k Immunek System--physiology. k 4.k Immunologick D eficiency
Syndromes. kQWk504] k QR1
81
616.07’9--dc23
2015029015
ExecutivekContentkStrategist: kJameskMerrittk Direct
or,kContentkDevelopment:kRebeccakGruliowk Publis
hing kServiceskManager: kCatherinekJackson k Seniork
ProjectkManager: kClay k S.k Broeker
Design kDirection: kBrian k Salisbury
Printed k in k Canada
Lastk digitk is k thek printk number:k 9 k k 8 k k 7 k k 6 k k 5 k k 4 k k 3 k k 2 k k 1
, To kourkstudents
k k
FunctionsandDisorders k k k
of the Immune System
k k k
F I F TH EDITION
k k
AbulkK. kAbbas, k MBBSkD is tingui
shedk Professork ink P athologyk Chair,k D e
partmentk ofk Pathologyk Univers ityk ofk C
aliforniak Sank Francis cok Sank Francis co,k
California
Andrewk H. k Lichtman, k MD, k PhD
Professork ofk Pathologyk Harvar
dk Medicalk School
Brighamkandk Women’s kHos pitalk Bos to
n,k Massachusetts
ShivkPillai, kMBBS, kPhD
ProfessorkofkM edicinek andk H ealthk Sciences k andk Technologyk H arva
rdk Medicalk S chool
RagonkInstitutekofk M ass achus etts k G eneralk Hos pital,k MIT kandkH arvardk Bos to
n,k Massachusetts
Illustrations k byk D avidk L.k Baker,k MAk A l
exandrak Baker,k MS,k CMI
DNA k Illustrations,k Inc.
,3251 k Riverportk Lane
St.k Louis, k Missourik 63043
BASICk IMMUNOLOGY:k FUNCTIONSk AND k D ISORD ERSk OF ISBN:k k 978-0-323-39082-8
THE k IMMUNE k SYSTEM, k Fifth k Edition
Copyright k©k20 16 kby kElsevier kInc. kAll krig ht skreserved.
Previous k editions k copyrighted k 2014,k 2011,k 2009,k 2006,k 2004,k and k 2001.
No k partk of k this k publication k may k bek reproduced kor k transmitted k in k any k formk or k byk any k means,k electron
ick or k mechanical, k includin gk photocopying, k recordin g, k or k any k information k storagek and k retrievalk syste
m,k withoutk permission k in k writingk from k thek publisher. k D etails k on k howk to k seek kpermission, k further k info
r-
k mation k aboutk thek Publisher’s k permissions k policies, k and k our k arrangements k with k organizations k such k as
k thek Copyrightk Clear ance k Center k and k thek Copyrightk Licensin gk Agency k can k bek found k atk our k website:k
www.elsevier.com/permissions .
This k book k andk thek individualk contributions k contained k in k itk arek protected k under k copyrightk by k thek Pub-
k lisher k (other k than k as k may k bek noted k herein).
Notices
Knowled gek and k bestk practicek in k this k field k arek constantly k changing. k As k newk research k andk experien
cek broaden k our k understanding, k changes k in k research k methods, k professionalk practices, k or k medicalk tr
eat- k mentk may k becomek necessary.
Practitioners k and k researchers k mustk always k rely k on k their k own k experiencek and k knowledgek in k eval
uatingk and k usingk any k information, k methods, k compounds,k or k experiments k described kherein. k In k usi
ngk such k information k or k methods k theyk shouldk bek mindfulk ofk their k own k safety k and k theksafety k of k ot
hers,k includingk parties k for k whom k they k havek ak professionalk responsibility.
With k respectk to k any k drugk or k pharmaceuticalk products k identified, k readers k arek advised k to k check k t
hek mostk currentk information k provided k (i)k on k procedures k featured k ork (ii) k by k thek manufacturer k of k e
ach k productk to k bek administered, k to k verify k thek recommended k dosek or kformula, k thek method k and k dur
ation k of k administration, k and k contraindications. k Itk is k thek responsibility k ofk practitioners, k relyingk on k
their k own k experiencek and k knowledgek of k their k patients, k to k makek diagnoses, k to k determinek dosages k
and k thek bestk treatmentk for k each k individualk patient, k and k to k takek allk appropriatek safety k precautions.
To k thek fullestk extentk of k thek law,k neither k thek Publisher k nor k thek authors, k contributors, k or k editorsk
assumek any k liability k for k any k injury k and/ork damagek to k persons k ork property k as k ak matter k of k products
k liability, k ne gligenc e k or k otherwise, k or k from k any kusek ork operation k of k anyk methods, k products, k instru
c- k tions,k or k ideas k contained k in k thek materialk herein.
Library k of k Congressk Cataloging-in-Publicatio nk Data
Abbas, k Abulk K.,k author.
Basick immunology k :k functions k and k disorders k of k thek immunek system k /k Abulk K.k Abbas, k Andrew
H.k Lichtman, k Shiv k Pillaik ;k Illustrations k by k D avid k L.k Baker,k Alexandrak Baker. k -- k Fifth k edition.
p.k ;k cm.
Includes kbibliographicalkreferences kand kindex.
k ISBNk 978-0-323-39082-8
I.k Lichtman, k Andrewk H.,k author. k II.k Pillai,k Shiv,k author. k III.k Title.
[ D NLM:k 1.k Immunity. k 2.k Hypersensitivity. k 3.k Immunek System--physiology. k 4.k Immunologick D eficiency
Syndromes. kQWk504] k QR1
81
616.07’9--dc23
2015029015
ExecutivekContentkStrategist: kJameskMerrittk Direct
or,kContentkDevelopment:kRebeccakGruliowk Publis
hing kServiceskManager: kCatherinekJackson k Seniork
ProjectkManager: kClay k S.k Broeker
Design kDirection: kBrian k Salisbury
Printed k in k Canada
Lastk digitk is k thek printk number:k 9 k k 8 k k 7 k k 6 k k 5 k k 4 k k 3 k k 2 k k 1
, To kourkstudents
