Week 8: NR546 / NR 546 (Latest Update 2025 / 2026) Advanced Pharmacology Psychopharmacology for the Psychiatric-Mental Health Nurse Practitioner | Questions with Verified Answers – Chamberlain.

Week 8: NR546 / NR 546 (Latest Update )
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Advanced Pharmacology Psychopharmacology for the i,- i,- i,- i,- i,-




Psychiatric-Mental Health Nurse Practitioner | i,- i,- i,- i,- i,-




Questions with Verified Answers – Chamberlain. i,- i,- i,- i,- i,-




Alzheimer's disease (AD) demographic i,- i,- i,- i,-i,- i,- most prevalent in i,- i,- i,-



people over age 65
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African American (13.8%),
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i,- Hispanics (12.2%), i,-




i,- non-Hispanic whites (10.3%), i,- i,- i,-




American Indian and Alaska Natives (9.1%),
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Asian and Pacific Islanders (8.4%)
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Genetics r/t AD Genes appear to play a strong role, with late-
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onset AD showing heritability of 58-79% and early-onset AD
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showing over 90% i,- i,-




Neuroanatomy r/t AD i,- i,- i,-i,- i,- amyloid plaques and neurofibrillary i,- i,- i,- i,-



tangles.
atrophy of hippocampus and cerebral cortex.
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, Neural Networks r/t AD
i,- damage to synapses, mitochondrial i,- i,- i,-i,- i,- i,- i,- i,- i,-



abnormalities, and inflammatory processes i,- i,- i,-




Neural Signaling r/t AD
i,- decreased acetylcholinesterase i,- i,- i,-i,- i,- i,- i,-



activity and a permanent loss of cholinergic neurons
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Acetylcholine (ACh) is a neurotransmitter necessary for i,- i,- i,- i,- i,- i,- i,-



processing memory and learning. i,- i,- i,-




Diagnosis of AD i,- i,- i,-i,- i,- comprehensive health history is key to i,- i,- i,- i,- i,- i,-



gather clues i,-




Rule out other causes of dementia
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Early AD may include anxiety, irritability, and sleep disruption
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new-onset mental health symptoms in late 50s and 60s may be in
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the early stage of AD
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Cholinesterase Inhibitors (ChEIs)X i,- i,- i,-i,- i,- do not change the
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progression of AD i,- i,-




provide some alleviation of symptoms
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eg. donepezil (Aricept), rivastigmine (Exelon), galantamine
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(Razadyne, Razadyne ER), i,- i,-




Early (1-3 years) signs of AD
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disoriented to date i,- i,-