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What drugs should be avoided with Kava Kava?
Alprazolam
CNS depressants (e.g., phenobarbital, zolpidem)
What is the normal range for TSH?
0.5 - 5.0 mu/L
What are lab values in Hyperthyroidism
Decreased TSH
Increased T4 and T3
What are labs in Hypothyroidism?
Increased TSH
Decreased T4 and T3
What are 5 primary symptoms of Hyperthyroidism?
Heat intolerance
Agitation, Anxiety, Irritability
Tachycardia
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Mood swings
Weight loss
What are 4 primary symptoms of Hypothyroidism?
Cold intolerance
Lethargy
Weight gain
Decreased libido
Hypothyroidism mimics symptoms of what psychiatric disorder?
Depression
Hyperthyroidism mimics symptoms of what psychiatric disorder?
Mania
Valproic acid produces what teratogenic effect?
Spina bifida (neural tube defect)
What is the primary organ where valproic acid is toxic?
Liver (hepatoxicity)
What are 4 signs of hepatoxicity?
Abdominal pain in the URQ
Reddish-brown urine
Yellowing of the skin and sclera
Fatigue
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What is the therapeutic range for valproic acid?
50-125 mcg/ml
What is a toxic level of valproic acid?
>150 mcg/ml
What are 4 signs of valproic acid toxicity?
Disorientation
Lethargy
Respiratory depression
Nausea/vomiting
A pt on Depakote C/O Abdominal pain in the URQ and Reddish-brown
urine. What do you suspect? What do you do?
Hepatotoxicity; hold med, draw LFT's (priority), DVP level
With suspected toxicity with valproic acid, what steps/labs should be
drawn?
D/C drug
Check drug level
Obtain LFTs
Obtain ammonia level
A pregnant pt is taking accutane, zyprexa and abilify; what med needs to
be d/c'd?
Accutane (used for acne; Causes birth Defects!!!)
What herbal supplement is used for anxiety, stress, and insomnia? What is
the major side effect with Kava Kava?
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Kava Kava
liver damage
What are 5 symptoms of Stephen's Johnson Syndrome?
Fever -Key sx to suspect SJS; high yield (HY)
burning of mouth/eyes -HY
Body aches
Severe red rash
Peeling skin
Facial and tongue swelling
Which mood stabilizer causes the least weight gain?
Lamotrigine (Lamictal)
Which 3 SGAs cause the least weight gain?
Lurasidone (Latuda)
Aripiprazole (Abilify)
Ziprasidone (Geodon)
Which SGA is the least sedating?
Aripiprazole (Abilify)
Your pt is taking Kava and you need to add an AS to manage their SCZ,
which do you add?
Aripiprazole (least sedating)
What are 2 hallmark symptoms of delirium?
Acute onset