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Advanced Pharmacology
Psychopharmacology for the
Psychiatric-Mental Health Nurse
Practitioner | Questions and
Answers | 100% Correct | Grade A -
Chamberlain
Question:
Cholinesterase Inhibitors (ChEIs)
Answer:
donepezil (Aracept)
rivastigmine (Exelon)
galantamine (Raxadyne)
, Question:
Donepezil (Aracept)
Answer:
Mechanism of Action
inhibits centrally active acetylcholinesterase
Common Side Effects
gastrointestinal symptoms (nausea and diarrhea)
headache
dizziness
muscle weakness
Precautions
sick sinus syndrome
seizure disorder
Prescribing Pearls
Taper to avoid withdrawal effects.
approved to treat moderate to severe AD at 23 mg/day dose
When donepezil (Aricept) is added to CYP2D6 or CYP3A4, there is a
possibility of peripheral side effects, and inducers of CYP2D6 and CYP3A4
may increase the rate of elimination
donepezil at a higher dose has a higher incidence of adverse effects without
increased cognitive benefit.