Midterm Exam: NR546 / NR 546
(Latest Update )
Advanced Pharmacology
Psychopharmacology for the
Psychiatric-Mental Health Nurse
Practitioner | Questions and
Answers | 100% Correct | Grade A -
Chamberlain
Question:
psychotropic drug metabolism may be impacted by
Answer:
age, smoking, caffeine, other meds, food
Question:
why do some drugs take time to take effect
Answer:
signal transduction cascades can produce downstream (delayed) and/or long
lasting effects
,Question:
5 dopamine pathways
Answer:
1. nigrostriatal
2. mesolimbic
3. mesocortical
4. tuberoinfundibular
5. thalamic
Question:
nigrostriatal
Answer:
-substantia nigra to basal ganglia or striatum
-extrapyramidal nervous sytem
-controls motor function and movement
-dopamine def = parkinsonism, tremor, rigidity, akinesia/bradykinesia,
tardive dyskinesia
-dopamine excess = hyperkinetic movements (tics, dyskinesia)
-remember nigrostriatal = eps
,Question:
mesolimbic
Answer:
-midbrain to ventral trigeminal nerve (VTA)
-part of limbic system
-pleasurable sensations, powerful euphoria of drug abuse, delusions,
hallucinations
-hypoactivity of pathway = anhedonia, apathy, lack of energy
-hyperactivity = impulsive, agistated, aggressive, hostile
-remember mesolimbic = positive symptoms
Question:
mesocortical
Answer:
=VTA to ventromedial prefrontal cortex (VMPFC)
-mediating cognitive symptoms of schizophrenia
-negative and cognitive symptoms of schizophrenia may be due to deficit of
DA activity in this pathway
-remember mesocortical = negative symptoms
, Question:
Tuberoinfundibular
Answer:
-hypothalamus to anterior pituitary
-controls prolactin secretion
-adverse effects = elevated prolactin levels are associated with galactorrhea
(breast secretions), gynecomastia (enlarged breasts esp in men), amenorrhea,
sexual dysfxn
-remember tuberoinfundibular = hyperprolactinemia
Question:
hyperprolactinemia
Answer:
serum prolactin level rises due to blockade of dopamine in hypothalamus.
may be asymptomatic or
-irregular menses
-male gynecomastia
-nipple discharge
-osteoporosis
- sexual dysfunction and infertility (both genders)
(Latest Update )
Advanced Pharmacology
Psychopharmacology for the
Psychiatric-Mental Health Nurse
Practitioner | Questions and
Answers | 100% Correct | Grade A -
Chamberlain
Question:
psychotropic drug metabolism may be impacted by
Answer:
age, smoking, caffeine, other meds, food
Question:
why do some drugs take time to take effect
Answer:
signal transduction cascades can produce downstream (delayed) and/or long
lasting effects
,Question:
5 dopamine pathways
Answer:
1. nigrostriatal
2. mesolimbic
3. mesocortical
4. tuberoinfundibular
5. thalamic
Question:
nigrostriatal
Answer:
-substantia nigra to basal ganglia or striatum
-extrapyramidal nervous sytem
-controls motor function and movement
-dopamine def = parkinsonism, tremor, rigidity, akinesia/bradykinesia,
tardive dyskinesia
-dopamine excess = hyperkinetic movements (tics, dyskinesia)
-remember nigrostriatal = eps
,Question:
mesolimbic
Answer:
-midbrain to ventral trigeminal nerve (VTA)
-part of limbic system
-pleasurable sensations, powerful euphoria of drug abuse, delusions,
hallucinations
-hypoactivity of pathway = anhedonia, apathy, lack of energy
-hyperactivity = impulsive, agistated, aggressive, hostile
-remember mesolimbic = positive symptoms
Question:
mesocortical
Answer:
=VTA to ventromedial prefrontal cortex (VMPFC)
-mediating cognitive symptoms of schizophrenia
-negative and cognitive symptoms of schizophrenia may be due to deficit of
DA activity in this pathway
-remember mesocortical = negative symptoms
, Question:
Tuberoinfundibular
Answer:
-hypothalamus to anterior pituitary
-controls prolactin secretion
-adverse effects = elevated prolactin levels are associated with galactorrhea
(breast secretions), gynecomastia (enlarged breasts esp in men), amenorrhea,
sexual dysfxn
-remember tuberoinfundibular = hyperprolactinemia
Question:
hyperprolactinemia
Answer:
serum prolactin level rises due to blockade of dopamine in hypothalamus.
may be asymptomatic or
-irregular menses
-male gynecomastia
-nipple discharge
-osteoporosis
- sexual dysfunction and infertility (both genders)
