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NBME PHARMACOKINETICS AND
PHARMACODYNAMICS EXAM NEWEST 2025
ACTUAL EXAM COMPLETE 160 QUESTIONS
AND CORRECT DETAILED ANSWERS
(VERIFIED ANSWERS) |100% GUARANTEED
PASS!
Which conditions decrease blood flow to tissues, thereby
reducing the effectiveness of drug therapy?
Select all that apply.
A. Abscess
B. Solid tumor
C. Amputation
D. Hemangioma
E. Adipose tissue - ANSWER-A, B
The small intestines have an ________________
environment where the stomach has an
________________ environment. - ANSWER-alkaline
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acidic
Young children and older adults have less
_________________ _______________ which results in
slower drug absorption or less absorption because of the
change of the pH in the stomach. - ANSWER-gastric
acidity
Which term refers to the rapid inactivation of some oral
drugs as they pass through the liver after being absorbed.
- ANSWER-first-pass effect
Many drugs bind reversibly to plasma
___________________. While bound, drug molecules
cannot leave the vascular system. It is important for
nurses to understand the concept of
___________________ ____________________ and
check patient's _________________ ______
_________________ levels when administering drugs. -
ANSWER-albumin
protein binding
protein and albumin
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A measure of the extent of drug absorption for a given
drug and route (from 0% to 100%). - ANSWER-
bioavailability
Drugs that are more than 90% bound to protein are known
as _____________________ protein-bound drugs (e.g.,
warfarin, glyburide, sertraline, furosemide, and
diazepam); drugs that are less than 10% bound to protein
are ____________________ protein-bound drugs (e.g.,
gentamicin, metformin, metoprolol, and lisinopril). -
ANSWER-highly
weakly
The portion of the drug bound to protein is inactive
because it is not available to interact with tissue receptors
and therefore is unable to exert a
______________________ effect. The portion that
remains unbound is free, active drug. Free drugs are able
to exit blood vessels and reach their ____________ ____
_____________, causing a pharmacologic response. -
ANSWER-pharmacologic
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site of action
BBB drugs are _______________ soluble and of
_____________ molecular weight. An example of a drug
that can cross the BBB
is...___________________________. (like Valium,
Xanax, Ativan) - ANSWER-lipid
low
Benzodiazepines
During pregnancy, drugs ______________ cross the
placenta much as they do across other membranes, and
this affects both the fetus and the mother. - ANSWER-can
Metabolism, or ______________________, is the process
by which the body chemically changes drugs into a form
that can be excreted. - ANSWER-biotransformation
The ______________ is the primary site of metabolism.
______________ enzymes—collectively referred to as
the cytochrome P450 system, or the P450 system, of
NBME PHARMACOKINETICS AND
PHARMACODYNAMICS EXAM NEWEST 2025
ACTUAL EXAM COMPLETE 160 QUESTIONS
AND CORRECT DETAILED ANSWERS
(VERIFIED ANSWERS) |100% GUARANTEED
PASS!
Which conditions decrease blood flow to tissues, thereby
reducing the effectiveness of drug therapy?
Select all that apply.
A. Abscess
B. Solid tumor
C. Amputation
D. Hemangioma
E. Adipose tissue - ANSWER-A, B
The small intestines have an ________________
environment where the stomach has an
________________ environment. - ANSWER-alkaline
,2|Page
acidic
Young children and older adults have less
_________________ _______________ which results in
slower drug absorption or less absorption because of the
change of the pH in the stomach. - ANSWER-gastric
acidity
Which term refers to the rapid inactivation of some oral
drugs as they pass through the liver after being absorbed.
- ANSWER-first-pass effect
Many drugs bind reversibly to plasma
___________________. While bound, drug molecules
cannot leave the vascular system. It is important for
nurses to understand the concept of
___________________ ____________________ and
check patient's _________________ ______
_________________ levels when administering drugs. -
ANSWER-albumin
protein binding
protein and albumin
,3|Page
A measure of the extent of drug absorption for a given
drug and route (from 0% to 100%). - ANSWER-
bioavailability
Drugs that are more than 90% bound to protein are known
as _____________________ protein-bound drugs (e.g.,
warfarin, glyburide, sertraline, furosemide, and
diazepam); drugs that are less than 10% bound to protein
are ____________________ protein-bound drugs (e.g.,
gentamicin, metformin, metoprolol, and lisinopril). -
ANSWER-highly
weakly
The portion of the drug bound to protein is inactive
because it is not available to interact with tissue receptors
and therefore is unable to exert a
______________________ effect. The portion that
remains unbound is free, active drug. Free drugs are able
to exit blood vessels and reach their ____________ ____
_____________, causing a pharmacologic response. -
ANSWER-pharmacologic
, 4|Page
site of action
BBB drugs are _______________ soluble and of
_____________ molecular weight. An example of a drug
that can cross the BBB
is...___________________________. (like Valium,
Xanax, Ativan) - ANSWER-lipid
low
Benzodiazepines
During pregnancy, drugs ______________ cross the
placenta much as they do across other membranes, and
this affects both the fetus and the mother. - ANSWER-can
Metabolism, or ______________________, is the process
by which the body chemically changes drugs into a form
that can be excreted. - ANSWER-biotransformation
The ______________ is the primary site of metabolism.
______________ enzymes—collectively referred to as
the cytochrome P450 system, or the P450 system, of
