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NSG 533 ADVANCED PHARMACOLOGY EXAM 3. QUESTIONS WITH 100% CORRECT ANSWERS.

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Tx for bipolar -Lithium ("A") was the first medication approved for treatment of bipolar mania and depression. It reduces the incidence of recurrence of mania, hypomania, and depression by about two-thirds. Lithium has a significant anti-suicide effect with an estimated eight- to ninefold reduction in risk. It is dosed at nighttime or twice daily. Lithium has a narrow therapeutic window, and there are numerous drug-drug interactions (including serotonergic drugs). -Both olanzapine (Zyprexa) and divalproex (Depakote) have FDA approval for treatment of acute mania and appear to be somewhat effective in the prevention of recurrent episodes. However, only lithium and lamotrigine (Lamictal) are FDA-approved mood stabilizers for bipolar treatment and maintenance. (lamictal is not for acute mania) -Carbamazepine (Tegretol) ("D") is a second-line agent that is also effective, but side effects limit its use. Atypical antipsychotics like olanzapine (Zyprexa), risperidone (Risperdal), ziprasidone (Abilify), and quetiapine (Seroquel) can also be used to treat acute mania. Side effects of atypical antipsychotics include extrapyramidal symptoms, sedation, and weight gain. Well recognized side effect of lithium hypothyroidism Which of the following drug classes do NOT alter lithium levels? opioids -Lithium is cleared by the kidney. Anything that can cause a change in renal function can affect lithium levels. NSAIDs, diuretics, ACE inhibitors, and ARBs can all affect renal function. What is important for decision making capacity ability to communicate a choice, voluntary choice, understanding of the variables involved in the decision, ability to appreciate the personal impact of choices What is true regarding dmc DMC is largely considered on a sliding-scale, rather than an "all-or-none" distinction, since the threshold for reaching DMC can vary widely from case to case or setting to setting. Even patients who have been declared legally incompetent or who have been legally and involuntarily committed may still have a measure of DMC (for example, meal choices, etc.). Moral theory typically urges clinicians to consider the wishes and reasoning of their patients as morally and clinically relevant, regardless of the placement of a legal guardian or the state as a surrogate decision-maker. DMC may ultimately be overridden in certain kinds of legal circumstances, but it should not be done lightly as it suggests a fundamental denial of patient autonomy

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NSG 533 EXAM 3
Goal of geriatric primary care
maintain independence, function, and comfort for the individual


Ageism
culturally rooted discomfort with growing older


Screening tools for dementia
Folstein Mini-Mental State Examination, the Mini-Cog screen for dementia, the Short
Portable Mental Status Questionnaire, the AD8 Dementia Screening Interview, and
the Montreal Cognitive Assessment (MoCa)


What helps in diagnosing dementia
detailed hx of cognitive change and lifelong habits most often provided by family or
friends, record of the patient's baseline mental status, ruling out depression as a
factor in impaired mental status, and tracking the results of subsequent mental
status testing are helpful for accurate diagnosis and management


USPSTF rec for screening for dementia
insufficient evidence to recommend for or against screening so generally testing
should be done only after concern for cognitive impairment is raised


Tools for the assessment of functional status

,Barthel Index, the Physical Self-Maintenance Scale, and the Katz Index


Function is addressed on two levels
(1) basic activities of daily living, including feeding, bathing, dressing, ambulation,
and toileting; and
(2) the more complex, instrumental activities of daily living, including cooking,
shopping, using the telephone, reading, writing, and managing money




Evidence-based recommendations for tests and screenings to help providers and
patients make decisions on appropriate care based on the individual's general
health, predicted longevity, and personal and family history
tests should focus on the function, comfort, and safety of the individual


The goal in completion of advance directives
provide the individual autonomy in decisions regarding his or her manner and
location of death as well as relieving family burden and conflict while the older
individual is mentally competent to do so.


Do advance directives need lawyers?
no, witnesses and notarization are all that are typically required. Typically emergency
medical technicians are unable to implement advance directives


The incidence of AD doubles when
every 5 years after 65y

,AD
chronic, irreversible illness with a gradual onset and a steady decline in cognition.
Short-term memory loss is the primary symptom in AD, along with one or more of the
following: disorientation; disturbance in executive functioning (planning, organizing,
and abstract thinking); problems with activities of daily living; and one of three
common neurologic disorders—aphasia, apraxia, or agnosia. Day-night sleep cycles
are often reversed; consciousness and psychomotor changes are not evident until
late in the disease. Irritability, withdrawal, and apathy may be exhibited in the early
stages of the disease. Psychotic symptoms such as paranoia, hallucinations,
delusions, and agitation can be seen later in the disease


Delirium
common cause of cognitive change in the sick or hospitalized older adult, is a
transient waxing and waning level of consciousness. It is characterized by acute
onset and fluctuations in orientation and attention


Most significant e/e imbalance in geriatrics
sodium imbalance d/t dehydration


Why dehydration is common in geriatrics
1. thirst response, which is stimulated by dehydration, is diminished and results in an
increased solute/water ratio.
2., decreased renal plasma flow may be responsible for a decline in the body's ability
to concentrate urine
3., vasopressin release stimulated by low fluid volume is diminished

, Clinical presentation of dehydration
vague/nonspecific, confusion, lethargy, rapid wt loss, functional decline, often
feature of FTT




PE for dehydration
cv assessment, may see orthostatic drop in BP and rise in HR, temp can be elevated,
dry mucous membranes in severe, poor skin turgor is unreliable in older adults,
tongue can be swollen and furrowed


Labs for dehydration
-electrolytes, bun/cr ratio, osmolality, hct/hg, glucose
-BUN/CR ratio > 25:1 =dehydration
-Na >148= dehydration
-with isotonic or hypotonic dehydration, serum sodium is normal or low
-HCT will be elevated
-UA and CXR appropriate


Oral fluid replacement
include half of the calculated fluid deficit plus ongoing losses in the first 24 hours,
totaling at least 1500 mL/day


SQ fluid rehydration
Maximum volume of (isotonic) fluid administered subcutaneously is 1500 mL per
site per 24 hours

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