PHARMACOLOGY TEST BANK QUESTIONS | TESTED
AND PROVEN ANSWERS | LATEST UPDATE
2024/2025 100% (GRADE A+)
The pKa (for the COOH group) of each of the three drugs is as follows: thyroxine = 3.0,
mesothyroxine = 4.0, neothyroxine = 5.0. Of these, which will be absorbed to the greatest extent
from the stomach (pH = 1.0)?
Ans>> neothyroxine
The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney cells by
exporting harmful chemicals against a concentration gradient in an energy-dependent manner.
What is this called?
Ans>> active transport
Phase II conjugates typically have the following property/properties
Ans>> rapidly excreted in the urine
A drug with a half-life of 2 hours is administered by continuous intravenous infusion. How long
will it take for the drug to reach 50% of its steady state concentration?
1
,Ans>> 2 hours
Caffeine is eliminated primarily by metabolism and with first order kinetics. The half-life of
caffeine varies significantly with individuals, but is on average 5.0 hours. The volume of
distribution is 0.60 L/kg. Joe has a mass of 70 kg and is an average subject with regard to
caffeine pharmacokinetics. He has a regular habit of consuming a cup of coffee (85 mg of
caffeine) at 8 am.
What is the clearance value (CL) of caffeine in a normal individual?
Ans>> 0.083 L/hr/kg
Which of the following routes is most likely to be affected by the first-pass effect?
Ans>> oral
A drug, given as a 150 mg single dose, results in a peak plasma concentration of 10 ug/mL. The
apparent volume of distribution is (rapid distribution and negligible elimination prior to measuring
the peak plasma level):
Ans>> 15 L
2
,Which of the following are routes of drug clearance?
-renal
-sweat
-intestines
Ans>> all of the above
What factor(s) may reduce drug bioavailability?
-gastric acid instability
-first-pass affect
-exposure to digestive enzymes
Ans>> all of the above
What type of receptor is the muscarinic receptor?
Ans>> G-protein coupled receptor
3
, For a cholinesterase modified by an organophosphate compound (e.g. soman), what is the time-
dependent dealkylation process called yielding an enzyme refractory toward reactivation?
Ans>> aging
Muscarinic receptors bind
Ans>> acetylcholine
Which of the following is a clinical use for a muscarinic agonist?
Ans>> "switching on" the urinary tract after surgery
Indirect cholinergic agonists cause
Ans>> inhibition of acetylcholinesterase and a corresponding increase in the synaptic
acetylcholine levels
Which of the following is characteristic of the sympathetic nervous system?
Ans>> responded predominate during physical activity or when experiencing fright
4
AND PROVEN ANSWERS | LATEST UPDATE
2024/2025 100% (GRADE A+)
The pKa (for the COOH group) of each of the three drugs is as follows: thyroxine = 3.0,
mesothyroxine = 4.0, neothyroxine = 5.0. Of these, which will be absorbed to the greatest extent
from the stomach (pH = 1.0)?
Ans>> neothyroxine
The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney cells by
exporting harmful chemicals against a concentration gradient in an energy-dependent manner.
What is this called?
Ans>> active transport
Phase II conjugates typically have the following property/properties
Ans>> rapidly excreted in the urine
A drug with a half-life of 2 hours is administered by continuous intravenous infusion. How long
will it take for the drug to reach 50% of its steady state concentration?
1
,Ans>> 2 hours
Caffeine is eliminated primarily by metabolism and with first order kinetics. The half-life of
caffeine varies significantly with individuals, but is on average 5.0 hours. The volume of
distribution is 0.60 L/kg. Joe has a mass of 70 kg and is an average subject with regard to
caffeine pharmacokinetics. He has a regular habit of consuming a cup of coffee (85 mg of
caffeine) at 8 am.
What is the clearance value (CL) of caffeine in a normal individual?
Ans>> 0.083 L/hr/kg
Which of the following routes is most likely to be affected by the first-pass effect?
Ans>> oral
A drug, given as a 150 mg single dose, results in a peak plasma concentration of 10 ug/mL. The
apparent volume of distribution is (rapid distribution and negligible elimination prior to measuring
the peak plasma level):
Ans>> 15 L
2
,Which of the following are routes of drug clearance?
-renal
-sweat
-intestines
Ans>> all of the above
What factor(s) may reduce drug bioavailability?
-gastric acid instability
-first-pass affect
-exposure to digestive enzymes
Ans>> all of the above
What type of receptor is the muscarinic receptor?
Ans>> G-protein coupled receptor
3
, For a cholinesterase modified by an organophosphate compound (e.g. soman), what is the time-
dependent dealkylation process called yielding an enzyme refractory toward reactivation?
Ans>> aging
Muscarinic receptors bind
Ans>> acetylcholine
Which of the following is a clinical use for a muscarinic agonist?
Ans>> "switching on" the urinary tract after surgery
Indirect cholinergic agonists cause
Ans>> inhibition of acetylcholinesterase and a corresponding increase in the synaptic
acetylcholine levels
Which of the following is characteristic of the sympathetic nervous system?
Ans>> responded predominate during physical activity or when experiencing fright
4
