NIH Principles and Practices of Clinical
Research (IPPCR) Final Exam UPDATED
ACTUAL Questions and CORRECT
Answers
Imhotep - CORRECT ANSWER - Egyptian, first physician figure to rise out of antiquity;
known scribe, priest, architect, astronomer and magician. performed surgery, practiced some
dentistry, extracted medicine from plants and knew the position and function of vital organs.
Hippocrates - CORRECT ANSWER - Father of modern medicine; Hipprocratic oath -->
high moral standards.
Which of the following is most likely a case series study? - CORRECT ANSWER -
Report of 5 cases of pneumocytosis pneumonia in previously healthy homosexual men
Scientific misconduct can cause which of the following? - CORRECT ANSWER - All of
the above
What is/are the reason(s) that NIH requires the inclusion of women and minorities in all clinical
research? - CORRECT ANSWER - All of the above
What can change a study's power and how power is impacted? - CORRECT ANSWER -
Variation in outcome (σ2): power decreases as an outcome's variance increases
A for-cause audit conducted by the Food and Drug Administration is best described as: -
CORRECT ANSWER - An audit performed to investigate possible fraud or misconduct
The use of common data elements (CDEs) should meet all of the following objectives EXCEPT:
- CORRECT ANSWER - To promote unneeded or redundant data collection
, True or False: Tests of general cognitive function, such as IQ tests and mini-mental status exams
(MMSE), provide effective tools for determining whether individuals can give informed consent
for a clinical trial. - CORRECT ANSWER - False
An h-index is a way to: - CORRECT ANSWER - Measure an author's productivity and
impact
Clinical trial registration is important so that: - CORRECT ANSWER - A and B only
a) existing trials are publicly available; b) Trials are made publicly available even if they are not
finished
It is important to be able to replicate the randomization results, i.e., reproduce the string of
treatment assignments. - CORRECT ANSWER - False
Scientific misconduct includes all of the following EXCEPT: - CORRECT ANSWER -
human error
Which of the following four statements is TRUE about patents? - CORRECT ANSWER -
To get worldwide patent protection, you will have to file a patent application in each and every
country.
Which of the following is NOT an example of a source document? - CORRECT
ANSWER - A worksheet that has a patient's height and weight abstracted or taken from
data in the medical record.
True or False: Planned interim data analyses, that require analysis of unblinded data, need to be
specified in the study protocol. - CORRECT ANSWER - True
A potential barrier to recruitment in clinical trials is/are: - CORRECT ANSWER - all of
the above
Research (IPPCR) Final Exam UPDATED
ACTUAL Questions and CORRECT
Answers
Imhotep - CORRECT ANSWER - Egyptian, first physician figure to rise out of antiquity;
known scribe, priest, architect, astronomer and magician. performed surgery, practiced some
dentistry, extracted medicine from plants and knew the position and function of vital organs.
Hippocrates - CORRECT ANSWER - Father of modern medicine; Hipprocratic oath -->
high moral standards.
Which of the following is most likely a case series study? - CORRECT ANSWER -
Report of 5 cases of pneumocytosis pneumonia in previously healthy homosexual men
Scientific misconduct can cause which of the following? - CORRECT ANSWER - All of
the above
What is/are the reason(s) that NIH requires the inclusion of women and minorities in all clinical
research? - CORRECT ANSWER - All of the above
What can change a study's power and how power is impacted? - CORRECT ANSWER -
Variation in outcome (σ2): power decreases as an outcome's variance increases
A for-cause audit conducted by the Food and Drug Administration is best described as: -
CORRECT ANSWER - An audit performed to investigate possible fraud or misconduct
The use of common data elements (CDEs) should meet all of the following objectives EXCEPT:
- CORRECT ANSWER - To promote unneeded or redundant data collection
, True or False: Tests of general cognitive function, such as IQ tests and mini-mental status exams
(MMSE), provide effective tools for determining whether individuals can give informed consent
for a clinical trial. - CORRECT ANSWER - False
An h-index is a way to: - CORRECT ANSWER - Measure an author's productivity and
impact
Clinical trial registration is important so that: - CORRECT ANSWER - A and B only
a) existing trials are publicly available; b) Trials are made publicly available even if they are not
finished
It is important to be able to replicate the randomization results, i.e., reproduce the string of
treatment assignments. - CORRECT ANSWER - False
Scientific misconduct includes all of the following EXCEPT: - CORRECT ANSWER -
human error
Which of the following four statements is TRUE about patents? - CORRECT ANSWER -
To get worldwide patent protection, you will have to file a patent application in each and every
country.
Which of the following is NOT an example of a source document? - CORRECT
ANSWER - A worksheet that has a patient's height and weight abstracted or taken from
data in the medical record.
True or False: Planned interim data analyses, that require analysis of unblinded data, need to be
specified in the study protocol. - CORRECT ANSWER - True
A potential barrier to recruitment in clinical trials is/are: - CORRECT ANSWER - all of
the above
