Leukocyte Adhesion Deficiency Which disease would occur if neutrophils have a deficiency in adhesion molecules, preventing migration? Chediak-Higashi syndrome What disease would occur if a neutrophil has phagocytosis and granule defects? Rolling, Int

Leukocyte Adhesion Deficiency Which disease would occur if neutrophils have a deficiency in adhesion molecules, preventing migration? Chediak-Higashi syndrome What disease would occur if a neutrophil has phagocytosis and granule defects? Rolling, Integrin Activation, Stable adhesion, and migration through endothelium What are the major steps in neutrophil extravasation? Selectins mediating weak tethering of blood leukocytes on the endothelium, and the sheer force of blood flow causes rolling along the endothelium surface What initiates the ROLLING step of neutrophil extravasation? Chemokynes bind to receptors on the rolling leukocytes, which activate leukocyte integrins to a strong binding state. What initiates the integrin activation step of neutrophil extravasation?