100% ACCURATE SOLUTIONS
Absolute Contraindications for liver transplant - Answer Severe cardiopulmonary
disease, uncontrolled HIV, poorly controlled Psych illness, noncompliance, anatomical
abnormalities precluding adequate surgical reconstruction
Reason for not accepted for liver TX - Answer Hepatocellular Carcinoma (HCC) outside
Milan Criteria
What is NAFLD? - Answer Nonalcoholic Fatty Liver Disease- caused by obesity,
hyperglycemia, elevated serum lipids, and high BP
What is NASH? - Answer Non-alcoholic steatohepatitis. Can lead to cirrhosis 3rd
common indication for liver TX.
What is the MELD score? - Answer MELD(Model for End Stage Liver Disease) is a
predictive model of death within a 3 month period. Ranks your degree of sickness,
shows how much you need a liver transplant. The higher the number, the more urgent
case is. Score ranges from 6-40.
*Score for HCC capped at 34.
Calculated using:
-INR
-Bilirubin
-Creatinine
-Sodium
, MELD > 14 needed for liver transplant
What can green drainage post liver TX indicate? - Answer Bile leakage
What can a rise in ALP post liver tx indicate? - Answer Can be a sign of biliary
complications or cholestasis
Lab changes are indicate of graft dysfunction. Which values will be elevated for liver tx?
- Answer Elevated AST and ALT
Target levels for immunosuppressants are based on a number of factors including: -
Answer Indication for tx, use of induction therapy, kidney function, overall condition of
pt.
What can lead to metabolic encephalopathy post liver transplant? - Answer Renal failure
or sepsis
What can lead to hypoxic ischemic encephalopathy post liver transplant? - Answer
Significant peri-operative hypotension
De Novo seizures can occur post liver transplant and can be caused by what? - Answer
Electrolyte imbalances, reaction to cyclosporine or tacrolimus, intracranial hemorrhage
or cerebral infarction and intracerebral abscesses
What can cause a post liver transplant patient whose initial postop neurological course
is normal to develop sudden deterioration in neurological status? - Answer Intracranial
bleed
Risk of primary non-function after liver transplant is: - Answer 4-6%