Microbiology Chapter 19 (Week 4) Terms in this set (56) 1) All of the following are true of hypersensitivity EXCEPT A) it occurs in the presence of an antigen. B) it is synonymous with allergy. C) it occurs when an individual is exposed to an a

Microbiology Chapter 19 (Week 4) Terms in this set (56) 1) All of the following are true of hypersensitivity EXCEPT A) it occurs in the presence of an antigen. B) it is synonymous with allergy. C) it occurs when an individual is exposed to an allergen for the first time. D) it is due to an altered immune response. E) it requires previous exposure to an antigen. C) it occurs when an individual is exposed to an allergen for the first time 2) The chemical mediators of anaphylaxis are A) found in basophils and mast cells. B) antibodies. C) antigens. D) antigen-antibody complexes. E) the proteins of the complement system. A) found in basophils and mast cells 3) Which of the following may result from systemic anaphylaxis? A) hay fever B) asthma C) shock D) hives E) immunodeficiency C) shock 4) Which antibodies will be in the serum of a person with blood type B, Rh+? A) anti-A, anti-B, anti-Rh B) anti-A, anti-Rh C) anti-A D) anti-B, anti-Rh E) anti-B C) anti-A 5) Which of the following types of transplant is least compatible? A) autograft B) allograft C) isograft D) xenotransplant E) All of these types of transplant are equally compatible. D) xenotransplant 6) When testing donated blood for compatibility you would find a person with O type blood A) has O type antigens on their red blood cells. B) will lack plasma antibodies to A and B type antigens. C) will lack A and B red blood cell antigens. D) lacks HLA and MHC antigens. E) will have anti-O antibodies in their plasma. C) will lack A and B red blood cell antigens Microbiology Chapter 19 (Week 4) 7) Graft-versus-host disease will most likely be a complication of a(n) A) skin graft. B) bone marrow transplant. C) blood transfusion. D) Rh incompatibility between mother and fetus. E) corneal transplant. B) bone marrow transplant 8) A positive tuberculin skin test is an example of A) delayed cell-mediated immunity. B) autoimmunity. C) acute contact dermatitis. D) psoriasis. E) innate immunity. A) delayed cell-mediated immunity 9) A healthy immune system destroys cancer cells with A) tumor-specific antigens. B) CTLs. C) CTLs and activated macrophages. D) activated macrophages. E) CD+ T cells. C) CTLs and activated macrophages 10) The symptoms of an immune complex reaction are due to A) destruction of the antigen. B) complement activation. C) phagocytosis. D) antibodies against self. E) cytokines. B) complement activation 11) Rheumatoid arthritis is due to deposition of A) IgG and IgA complexes in joints. B) IgA antibodies in joints. C) IgD and IgE complexes in joints. D) complement in joints. E) complexes of IgM and IgG and also complement in joints. E) complexes of IgM and IgG and also complement in joints 12) Allergic contact dermatitis is due to A) sensitized T cells. B) IgG antibodies. C) IgE antibodies. D) IgM antibodies. E) activated macrophages. A) sensitized T cells 13) Attachment of HIV to the target cell depends on A) gp120 combining with the CD4+ receptor. B) gp120 combining with the chemokine receptor CCR5. C) gp41 binding to the CD4+ receptor. D) gp120 binding to the CD4+ plasma membrane. E) CXCR4 binding to the CD4+ receptor. A) gp120 combining with the CD4+ receptor 14) All of the following pertain to serological tests EXCEPT A) they can detect antibodies but not antigens. B) they can be used to diagnose various diseases. C) reactions can be detected by uptake of trypan blue by damaged cells. D) they are used to test for specific HLAs on lymphocytes. E) they are used to detect compatible tissues for transplantation. A) they can detect antibodies but not antigens 15) The process of desensitization to prevent allergies involves the injection of increasing amounts of A) IgE. B) IgG. C) antihistamine. D) antigen. E) RhoGAM. D) antigen 16) Which of the following statements about type I reactions is FALSE? A) They involve helper T cells. B) They involve IgE antibodies. C) The symptoms are due to histamine. D) Antibodies bind to mast cells and basophils. E) The symptoms occur soon after exposure to an antigen. A) They involve helper T cells 17) Which of the following statements about type IV reactions is FALSE? A) Reactions are primarily due to T cell proliferation. B) Reactions are not apparent for a day or more. C) Cytokines initiate tissue damage. D) Allergic contact dermatitis is an example. E) Hemolytic disease of the newborn is an example. E) Hemolytic disease of the newborn is an example Which blood transfusions in Table 19.1 are incompatible? A) 2 and 5 B) 1, 2, and 3 C) 2, 3, and 5 D) 3 and 4 E) 1 and 2 C) 2, 3, and 5 19) Hemolytic disease of the newborn can result from an A) Rh+ mother with an Rh fetus. B) Rh mother with an Rh+ fetus. C) AB mother with a B fetus. D) AB mother with an O fetus. E) Rh mother and an A fetus. B) Rh mother with an Rh+ fetus 20) Which is true regarding Herceptin therapy? A) It neutralizes the growth factor EGF. B) It acts as an immunotoxin to target and kill cancer cells. C) It is used to treat some breast cancer patients. D) It is a vaccine to prevent the development of cancer. E) It is an endotoxin that stimulates TNF by macrophages. C) It is used to treat some breast cancer patients 21) Which of the following utilizes a combination of monoclonal antitumor antibody and immunotoxin? A) immunologic enhancement B) immunologic surveillance C) immunotherapy D) immunosuppression E) immune complex C) immunotherapy 22) All of the following are reasons why an HIV vaccine has not been developed EXCEPT A) there is no known animal model of natural immunity for HIV infection. B) use of a weakened virus would potentially transmit the infection. C) small, inexpensive animals which could be used for HIV vaccine research are not available. D) vaccines are not effective against viral infections. E) HIV has a high mutation rate so one vaccination would not be effective to treat the world-wide pandemic. D) vaccines are not effective against viral infections 23) Treatment with certain drugs to reduce transplant rejection can cause A) immunologic enhancement. B) immunologic surveillance. C) immunotherapy. D) immunosuppression. E) autoimmunity. D) immunosuppression 24) Which of the following statements about human embryonic stem cells is TRUE? A) They are obtained in great numbers from umbilical cords of newborns. B) They express no MHC II antigens. C) They are pluripotent. D) They are typically obtained from the zygote stage of embryonic development. E) They are pluripotent and typically obtained from the blastocyst stage of embryonic development. E) They are pluripotent and typically obtained from the blastocyst stage of embryonic development 25) In immune complex reaction shown in Figure 19.1, what is the small, circular/spherical structure labeled a? A) antibody B) antigen C) complement D) neutrophil E) mast cell B) antigen 26) In immune complex reaction shown in Figure 19.1, what is the end result of the reaction? A) IgG is directed against cell membrane antigens. B) Complement is activated. C) Neutrophils are attracted and release enzymes. D) Endothelial cells are damaged. E) Antibodies destroy neutrophils. D) Endothelial cells are damaged 27) Worldwide, the primary method of transmission of HIV is A) heterosexual intercourse. B) homosexual intercourse. C) intravenous drug use. D) blood transfusions. E) nosocomial. A) heterosexual intercourse 28) HIV spikes attach to CD4+ receptors found on A) T helper cells. B) macrophages. C) dendritic cells. D) T helper cells and macrophages. E) T helper cells, macrophages, and dendritic cells. E) T helper cells, macrophages, and dendritic cells 29) Which of the following is the least likely vaccine against HIV? A) attenuated virus B) glycoprotein C) protein core D) subunit E) All of these vaccines are equally likely. A) attenuated virus Microbiology Chapter 19 (Week 4) 34) Anaphylaxis is the term for reactions caused when certain antigens combine with A) IgE antibodies. B) macrophages. C) IgG antibodies. D) complement. E) histamine. A) IgE antibodies 35) All of the following regarding immune privileged sites are true EXCEPT A) they include corneal and brain tissue. B) they do not have lymphatic vessels. C) they are rarely rejected. D) they include any tissue transplanted from a pig. E) they explain how animals tolerate pregnancies without rejecting the fetus. D) they include any tissue transplanted from a pig 36) All of the following are considered examples of type I hypersensitivity EXCEPT A) asthma. B) dust allergies. C) penicillin allergic reactions. D) pollen allergies. E) transplant rejections. E) transplant rejections 37) All of the following lead to drug-induced thrombocytopenic purpura. Which occurs first? A) Antibodies and complement react with platelets. B) Antibodies against haptens are formed. C) Drug binds to platelets. D) Platelets are destroyed. C) Drug binds to platelets Microbiology Chapter 19 (Week 4) 38) Immunodeficiencies are a result of all of the following EXCEPT A) HIV infection. B) cyclosporine. C) DiGeorge syndrome. D) Hodgkins disease. E) autoimmune diseases. E) autoimmune diseases 39) Which of the following describes a cytotoxic autoimmune reaction? A) Antibodies react to cell-surface antigens. B) Antibodies are not made. C) Cells are killed. D) Immune complexes form. E) Mediate by T cells. A) Antibodies react to cell-surface antigens 40) Symptoms of delayed cell-mediated reactions are due to A) IgE antibodies. B) neutrophils. C) cytokines. D) IgG antibodies. E) antigens. C) cytokines 41) Desensitization involves injection of A) antigens. B) IgG antibodies. C) IgE antibodies. D) antihistamine. E) histamine. A) antigens 42) In the serological method for tissue typing, if human cells expressing HLA-I are mixed with anti-HLA-I, complement, and trypan blue, what would indicate the cells are HLA-I? A) Enzyme is released from neutrophils. B) Cells are damaged by complement. C) Trypan blue enters the cells. D) Anti-HLA antibodies bind to HLAs on lymphocytes. E) None of the answers are correct; the T cells are missing. C) Trypan blue enters the cells 43) In rheumatoid arthritis, IgM, IgG, and complement deposit in joints. This is an example of A) cytotoxic autoimmunity. B) immune complex autoimmunity. C) cell-mediated autoimmunity. D) immunosuppression. E) acquired immunodeficiency. B) immune complex autoimmunity 44) The number of T cells drops to below 200 cells/microliter in which phase of HIV infection? A) phase 1 B) phase 2 C) phase 3 D) initial phase E) asymptomatic phase C) phase 3 45) HIV can evade host antibodies by A) remaining an inactive provirus. B) causing cell-to-cell fusion. C) remaining an inactive provirus, causing cell to cell fusion, and virions remaining latent in vacuoles. D) lowering the CD4+ cell count. E) virions remaining latent in vacuoles. C) remaining an inactive provirus, causing cell to cell fusion, and virions remaining latent in vacuoles 1) Individuals who do not express CCR5 are highly resistant to infection by HIV. True or False? TRUE 2) Vaccines against HIV have proven to be very effective in halting the spread of disease. True or False? FALSE 3) All hypersensitivities involve antibody- antigen reactions. True or False? FALSE 4) Skin tests are reliable indicators for the diagnosis of food-related allergies. True or False? FALSE 5) HIV attack of CD4+ T cells causes suppression of both cell-mediated and humoral immune responses. True or False? TRUE 6) Autoimmune diseases occur when the immune system is unable to discriminate self from nonself. True or False? TRUE 7) Xenotransplantation is an effective alternative to using isografts. True or False? FALSE 8) All stem cells are derived from embryonic stem cells. True or False? FALSE 9) Cancer is similar to an infectious disease in that it is due to a failure of the bodys defenses. True or False? TRUE 10) HIV is believed to have arisen by mutation of a virus endemic to wild animals in Africa. True or False? TRUE 11) A hypersensitivity reaction refers to immune responses to antigens beyond what would be normal. True or False? TRUE