NURS 5315 Exam 4: Musculoskeletal With Questions And Answers 2024 Graded A+ 100% verified Answers (BRANDNEW).

Which cells are responsible for the formation of bone through ossification or osteogenesis? - ANSWER-Osteoblasts What is the name of mature bone cells, that take part in bone maintenance? - ANSWER-Osteocytes What cells are responsible for bone resorption and remodeling? - ANSWER-Osteoclasts What are the components of the bone matrix? - ANSWER-1/3 Organic collection and porteoglycans 2/3 Inorganic Hydroxyapatite What occurs in the Quiescent phase of bone remodeling? - ANSWER-The resting bone with lining cells remains dormant until is it activated What occurs in the Activation phase? - ANSWER-Monocyte precursor cells (Pre-Osteoclasts) are attracted to the remodeling site. Osteoblasts produce RANKL which bind to the RANK receptors on Monocyte precursor cells. The precursor cells come together to form a multi nucleated Osteoclast What is the Reabsorption Phase? - ANSWER-Osteoclasts secrete lysosomal enzymes (collagenase) which digest the collagen in the organic matrix. This drills pits in the bone surface called Howship's Lacunae What do osteoblast secrete that binds to RANKL in order to control bone reabsorption? - ANSWER-Osteoprotegerin What phase of bone remodeling is when mesenchymal stem cell precursors differentiate into osteoblasts along the resorption pit, proliferating and increasing in number before maturing into pre osteoblasts and then mature osteoblasts? - ANSWER-Reversal Phase What is the Formation Phase? - ANSWER-Mature Osteoblasts line erosion cavity and release osteoid seam at the surface of the pit, forming a new, soft mineralized matrix. This new matrix is mineralized with calcium and phosphorus