AQA GCSE BIOLOGY 8461/1H Paper 1 Higher Tier Version: 1.0 Final *jun2384611H01* IB/M/Jun23/E25 8461/1H QUESTION PAPER & MARKING SCHEME/ [MERGED] Marl( scheme June 2023

AQA GCSE BIOLOGY 8461/1H Paper 1 Higher Tier Version: 1.0 Final *jun2384611H01* IB/M/Jun23/E25 8461/1H For Examiner’s Use Question Mark 1 2 3 4 5 6 TOTAL Tuesday 16 May 2023 Morning Time allowed: 1 hour 45 minutes Materials For this paper you must have: • a ruler • a scientific calculator. Instructions • Use black ink or black ball-point pen. • Pencil should only be used for drawing. • Fill in the boxes at the top of this page. • Answer all questions in the spaces provided. • If you need extra space for your answer(s), use the lined pages at the end of this book. Write the question number against your answer(s). • Do all rough work in this book. Cross through any work you do not want to be marked. • In all calculations, show clearly how you work out your answer. Information • The maximum mark for this paper is 100. • The marks for questions are shown in brackets. • You are expected to use a calculator where appropriate. • You are reminded of the need for good English and clear presentation in your answers. Please write clearly in block capitals. Centre number Candidate number Surname Forename(s) Candidate signature I declare this is my own work. GCSE BIOLOGY Higher Tier Paper 1H H 2 *02* IB/M/Jun23/8461/1H Do not write outside the There are no questions printed on this page box DO NOT WRITE ON THIS PAGE ANSWER IN THE SPACES PROVIDED 3 *03* Turn over ► IB/M/Jun23/8461/1H Do not write outside the Answer all questions in the spaces provided. box 0 1 A root is a plant organ. Plant roots contain many different types of tissue. 0 1 . 1 What is a tissue? [1 mark] 0 1 . 2 Tissue in the tip of a plant root contains stem cells. Stem cells can differentiate into any type of cell. Name the type of tissue in plants that contains stem cells. [1 mark] In the past many drugs were extracted from plants. 0 1 . 3 Aspirin is a painkiller. Which plant does aspirin originate from? [1 mark] Question 1 continues on the next page 4 *04* IB/M/Jun23/8461/1H Do not write outside the box Scientists have extracted chemical A from the deadly nightshade plant. Chemical A can be used as a painkiller. Table 1 shows information about where chemical A is found. Table 1 Part of deadly nightshade plant Mass of chemical A in 100 g of plant tissue in grams Roots 1.3 Leaves 1.2 Berries 0.7 0 1 . 4 The scientists usually extract chemical A from the berries of the deadly nightshade plant. Suggest one reason why berries are used instead of leaves or roots. [1 mark] 5 *05* Turn over ► IB/M/Jun23/8461/1H Do not write outside the A deadly nightshade plant has chlorosis (yellow leaves). box The mass of chemical A found in the leaves of the plant is 60% of the mass shown in Table 1. 0 1 . 5 Calculate the mass of chemical A in 200 g of the leaves with chlorosis. Give your answer in mg. [4 marks] Mass of chemical A = mg 0 1 . 6 Suggest one reason why the leaves of the deadly nightshade plant have chlorosis. [1 mark] Question 1 continues on the next page 6 *06* IB/M/Jun23/8461/1H Do not write outside the Chemical A has not been tested in large box -scale clinical trials in the UK. 0 1 . 7 It is important for drugs to be tested in clinical trials before the drugs are approved for use by the public. Give two reasons why. [2 marks] 1 2 There are many online reports making claims about the effects of chemical A. Some of these reports are biased. 0 1 . 8 Suggest one reason why a report making claims about the effects of chemical A may be biased. [1 mark] 7 *07* Turn over ► IB/M/Jun23/8461/1H Do not write outside the box 0 1 . 9 How can scientists be sure that claims about new drugs are valid? [1 mark] Tick () one box. Advertise the claims on social media. Ask an international company to produce the drug. Have the claims peer reviewed. Publish the claims in a newspaper. Turn over for the next question 13 8 *08* IB/M/Jun23/8461/1H Do not write outside the box 0 2 This question is about the circulatory system. Figure 1 shows the human heart. Figure 1 0 2 . 1 Which part of the heart receives oxygenated blood from the lungs? [1 mark] Tick () one box. A B C D 0 2 . 2 Which part of the heart pumps deoxygenated blood to the lungs? [1 mark] Tick () one box. A B C D 9 *09* Turn over ► IB/M/Jun23/8461/1H Do not write outside the box 0 2 . 3 A group of cells called the pacemaker controls the resting heart rate. Where in the heart is the pacemaker found? [1 mark] Tick () one box. Left atrium Left ventricle Right atrium Right ventricle 0 2 . 4 Figure 2 shows a cross section of an a