Chapter 09: Antibacterial Drugs That Interfere With DNA/RNA Synthesis Introductory Clinical Pharmacology 12th Edition by Susan M Ford

Introductory Clinical Pharmacology 12th Edition by Susan M Ford 1. A nurse is preparing to administer ciprofloxacin as prescribed. Which test would the nurse ensure is completed before administering the first dose to the client? a. Urinalysis b. Culture tests c. Ulcer tests d. Stool tests Answer: B Rationale: The nurse should check whether culture tests are conducted before the first dose of drug is administered to the client. Ulcer tests and stool tests are not required to be conducted before administering the first dose of an anti-infective drug to the client. The nurse has to ensure that urinalysis is conducted before the administration of the drug but not specifically before the first dose of the anti-infective drug. Question Format: Multiple Choice Chapter: 9 Learning Objective: 2 Cognitive Level: Apply Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Clinical Problem-solving Process (Nursing Process) Reference: p. 111, Preadministration Assessment 2. A nurse is caring for a client who is receiving a fluoroquinolone as an intravenous infusion. The nurse would check the infusion rate at which frequency? a. Every 15 minutes b. Every 30 minutes c. Every 45 minutes d. Every 60 minutes Answer: A Rationale: When administering a fluoroquinolone IV, the nurse should check the infusion rate every 15 minutes and adjust it if necessary. Question Format: Multiple Choice Chapter: 9 Learning Objective: 2 Cognitive Level: Apply Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Clinical Problem-solving Process (Nursing Process) Reference: p. 112, Intravenous Administration 3. A client is questioning the nurse about a superinfection that developed while receiving fluoroquinolone therapy. Which response by the nurse would be most appropriate? a. “Your infection was really severe, so the drug wasn't as effective as it could have been.” b. “This happens when your original infection begins to clear.” c. “The drug disrupts your normal bacteria so it allows other organisms to grow.” d. “We really don't know why this happens; it just does sometimes.” Answer: C Rationale: Antibiotics can disrupt the normal flora (nonpathogenic bacteria in the bowel), causing a secondary infection or superinfection. This new infection is “superimposed” on the original infection. The destruction of large numbers of nonpathogenic bacteria (normal flora) by the antibiotic alters the chemical environment. This allows uncontrolled growth of bacteria or fungal microorganisms that are not affected by the antibiotic being administered. It has nothing to do with the drug's effectiveness or the original infection being cleared. Question Format: Multiple Choice Chapter: 9 Learning Objective: 4 Cognitive Level: Apply Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Teaching/Learning Reference: p. 109, Superinfections 4. A client develops pseudomembranous colitis secondary to fluoroquinolone therapy. The nurse anticipates the bowel culture will grow which organism? a. E. coli b. C. difficile c. Staphylococcus d. Group B hemolytic Streptococcus Answer: B Rationale: Pseudomembranous colitis is one type of a bacterial superinfection. This potentially life-threatening problem develops because of an overgrowth of the microorganism Clostridium difficile (C. diff) in the bowel. Question Format: Multiple Choice Chapter: 9 Learning Objective: 1 Cognitive Level: Understand Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Clinical Problem-solving Process (Nursing Process) Reference: p. 109, Superinfections 5. The nurse is evaluating the medical records of several clients and note some are receiving both fluoroquinolone and corticosteroid therapy. The nurse concludes which client is at the greatest risk for tendonitis?