CRNA pharmacology for nurse anesthesia Review Test Q & A
2023/2024 VERIFIED
pharmacokinetics vs. pharmacodynamics correct answers Pharmacokinetics: What the BODY does on the
drug
Pharmacodynamics: What the DRUG does on the body
four components of pharmacokinetics correct answers absorption, distribution, metabolism, excretion
three components of pharmacodynamics correct answers mechanism of effect, sensitivity,
responsiveness
four commonly measured pharmacokinetic parameters of IV drugs correct answers elimination half-
time, bioavailability, clearance, volume of distribution
Define bioavailability correct answers how much drug administered is available at the site of action
define volume of distribution correct answers the volume that the drug is able to distribute into
compartments in the two components model correct answers central, peripheral
define central compartment correct answers highly perfused tissues: kidney, liver, lungs, heart, brain,
and vessels
what pathway does a drug take between the two compartments correct answers introduced into central,
distributes into peripheral, returns to central for clearance
what % of CO does the central compartment receive? what % of body mass does it represent correct
answers 75% of CO
10% of mass
what is the peripheral compartment correct answers the not highly perfused organs/tissues
what are the characteristics of the peripheral compartment correct answers large volume, extensive
uptake of drug
what type of drugs will transfer easily between plasma and tissues correct answers highly lipid soluble
how does aging affect the rate of transfer between compartments correct answers decrease it, leading
to greater plasma concentration
what causes a drug to leave the peripheral compartment correct answers drop in plasma concentration
below peripheral compartment concentration due to clearance
how are the duration of effect and elimination half-time related in lipophilic drugs correct answers
duration of effect much shorter than elimination half-time
2023/2024 VERIFIED
pharmacokinetics vs. pharmacodynamics correct answers Pharmacokinetics: What the BODY does on the
drug
Pharmacodynamics: What the DRUG does on the body
four components of pharmacokinetics correct answers absorption, distribution, metabolism, excretion
three components of pharmacodynamics correct answers mechanism of effect, sensitivity,
responsiveness
four commonly measured pharmacokinetic parameters of IV drugs correct answers elimination half-
time, bioavailability, clearance, volume of distribution
Define bioavailability correct answers how much drug administered is available at the site of action
define volume of distribution correct answers the volume that the drug is able to distribute into
compartments in the two components model correct answers central, peripheral
define central compartment correct answers highly perfused tissues: kidney, liver, lungs, heart, brain,
and vessels
what pathway does a drug take between the two compartments correct answers introduced into central,
distributes into peripheral, returns to central for clearance
what % of CO does the central compartment receive? what % of body mass does it represent correct
answers 75% of CO
10% of mass
what is the peripheral compartment correct answers the not highly perfused organs/tissues
what are the characteristics of the peripheral compartment correct answers large volume, extensive
uptake of drug
what type of drugs will transfer easily between plasma and tissues correct answers highly lipid soluble
how does aging affect the rate of transfer between compartments correct answers decrease it, leading
to greater plasma concentration
what causes a drug to leave the peripheral compartment correct answers drop in plasma concentration
below peripheral compartment concentration due to clearance
how are the duration of effect and elimination half-time related in lipophilic drugs correct answers
duration of effect much shorter than elimination half-time
