Oncology NAPLEX | 98 Questions and Answers(A+ Solution guide)

anti-emetic regimen for highly emetogenic chemotherapy - fosapretant + dexmethasone + ondansetron + olanzapine 3 or 4 drug regimen NK1-RA + 5HT3- RA + dexmethasone + olanzapine nadir - lowest point that WBS and platelets reach in chemo usually occurs 7-14 days after Tamoxifen MOA - SERM - Selective Estrogen Receptor Modulators - block estrogen in breast tissue but can act as estrogen agonists elsewhere. Used when tumor is estrogen-receptor positive. treat and prevent recurrence of ER(+)breast cancer **can be used in BOTH pre and post-menopausal women -Antagonist at breast -AGONIST at bone and uterus (detrimental agonistic effect by increasing the risk of uterine cancer and of thrombo-embolism) chemo agents that are CELL cycle INDEPENDENT - alkalyating agents (cyclophosphamide)anthracycline agents (doxorubicin) platinum agents (cisplatin) Zofran MOA - 5HT3 antagonist (-) Amofostine (ethiyol) - given with cisplatin to reduce risk of renal toxicities -given prophylactically with hydration Neupogen - (Filgrastim) Colony stimulating factor Stimulates neutrophil production; decreases infection in neutropenic pts IV, subcut SEs: Splenic rupture, ARDS, allergic rxn, medullary bone pain NCs: do not admin w/in 24 hrs either side of chemo Bone pain is common SE, mgmt w opioids if necc Pegfilgrastim - Neulasta Hematopoietic Agent/Colony Stimulating Factor Given once (t1/2 14 days)Prostate cancer screening - digital rectal exam