Pharm Lecture Exam 1 | Questions & 100% Correct Answers | Abrams' clinical drug therapy: rationales for nursing practice. 10th ed. Lecture exam one study questions

Pharm Lecture Exam 1 | Questions & 100% Correct Answers Pharm Lecture Exam 1 | Questions & 100% Correct Answers Abrams' clinical drug therapy: rationales for nursing practice. 10th ed. Lecture exam one study questions MEC - ANSWER - Minimum effective concentration Minimum amount required to reach efficacy loading dose - ANSWER - initial dose that gets you up to the MEC then levels off to keep you at that dose Maintenance Dose - ANSWER - Dose that keeps you at the MEC ED - ANSWER - EFFECTIVE DOSE FOR 50% OF TEST GROUP LD - ANSWER - LETHAL DOSE FOR 50% OF TEST GROUP TD - ANSWER - TOXIC DOSE FOR 50% OF TEST GROUP. Excessive level of medication in bloodstream; caused by a Single large dose, Repeated small doses, Slow metabolism of medication Range - ANSWER - obtained by dividing the Lethal dose by the effective dose. The larger the range the safer the drug. Serum half life - ANSWER - the time required for the serum concentration in the blood to be decreased by 50%. The shorter the half life the more frequent you will need to give it Serum drug level - ANSWER - a laboratory measurement of the amount of a drug in the blood at a particular time that reflects dosage, absorption, bioavailability, half-life, & rates of metabolism, excretion distribution - ANSWER - the transport of drug molecules within the body pharmacodynamics - ANSWER - What the drug is doing to our body by: Activation, inactivation, or alteration of intracellular enzymes. It can change the permeability of cell membranes to one or more ions, or modify the synthesis, release, or inactivation of neurohormones. They can never completely change the functions of the cell, just alter it in someway Nonreceptor drug actions - ANSWER - Relatively few drugs do not act on receptor sites. These few drugs include, Antacids, Osmotic diuretics, Several anticancer drugs, Metal chelating agents