AQA GCSE COMBINED SCIENCE: TRILOGY 8464/B/1H Biology Paper 1H Question Paper + Mark scheme [MERGED] June 2022 *jun228464b1h01* IB/M/Jun22/E14 8464/B/1H For Examiner’s Use Question Mark

AQA GCSE COMBINED SCIENCE: TRILOGY 8464/B/1H Biology Paper 1H Question Paper + Mark scheme [MERGED] June 2022 *junb1h01* IB/M/Jun22/E14 8464/B/1H For Examiner’s Use Question Mark 1 2 3 4 5 6 TOTAL Time allowed: 1 hour 15 minutes Materials For this paper you must have: • a ruler • a scientific calculator. Instructions • Use black ink or black ball-point pen. • Pencil should only be used for drawing. • Fill in the boxes at the top of this page. • Answer all questions in the spaces provided. • If you need extra space for your answer(s), use the lined pages at the end of this book. Write the question number against your answer(s). • Do all rough work in this book. Cross through any work you do not want to be marked. • In all calculations, show clearly how you work out your answer. Information • The maximum mark for this paper is 70. • The marks for questions are shown in brackets. • You are expected to use a calculator where appropriate. • You are reminded of the need for good English and clear presentation in your answers. Please write clearly in block capitals. Centre number Candidate number Surname Forename(s) Candidate signature I declare this is my own work. GCSE COMBINED SCIENCE: TRILOGY Higher Tier Biology Paper 1H H 2 *02* IB/M/Jun22/8464/B/1H There are no questions printed on this page DO NOT WRITE ON THIS PAGE ANSWER IN THE SPACES PROVIDED Do not write outside the box 3 *03* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the 0 1 Bacteria can cause a variety of diseases in humans. box 0 1 . 1 What are two similarities between a bacterial cell and an animal cell? [2 marks] Tick () two boxes. Both have a cell membrane. Both have a cell wall. Both have a nucleus. Both have cytoplasm. Both have plasmids. 0 1 . 2 Salmonella food poisoning is caused by bacteria in food. Give one symptom of salmonella food poisoning. Do not refer to vomiting or diarrhoea in your answer. [1 mark] Question 1 continues on the next page 4 *04* IB/M/Jun22/8464/B/1H Do not write outside the 0 1 box . 3 What is the name of the first antibiotic developed? [1 mark] A child with a severe bacterial infection was given a course of antibiotics. Figure 1 shows how the concentration of live bacteria in the child’s body changed when taking the course of antibiotics. Figure 1 5 *05* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 0 1 . 4 The concentration of live bacteria in the body continued to increase after starting the course of antibiotics. Suggest one reason why. [1 mark] 0 1 . 5 After 3 days of taking the antibiotic: • the child felt better • there were still bacteria in the child’s body. Why did the child feel better? [1 mark] Tick () one box. Bacteria had become immune to the antibiotic. The child had become resistant to the bacteria. There were fewer toxins in the body than at day 0 0 1 . 6 Suggest why doctors do not give antibiotics to patients with minor infections. [1 mark] Question 1 continues on the next page 6 *06* IB/M/Jun22/8464/B/1H Do not write outside the box 9 Figure 2 shows blood viewed using a microscope. Figure 2 0 1 . 7 A vaccine will stimulate the production of antibodies. Which part of the blood in Figure 2 produces antibodies? [1 mark] Tick () one box. A B C D 0 1 . 8 Which part of the blood in Figure 2 starts the clotting process? [1 mark] Tick () one box. A B C D 7 *07* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the 0 2 This question is about cell division. box 0 2 . 1 Write the biological structures from the box in the correct order of size. [1 mark] cell chromosome gene nucleus Smallest Largest Question 2 continues on the next page 8 *08* IB/M/Jun22/8464/B/1H Do not write outside the Figure 3 shows how a fertilised egg cell can produce specialised cells. box Figure 3 0 2 . 2 Name Process A. [1 mark] 0 2 . 3 How many cell divisions are needed to form a 16-cell embryo from the original fertilised egg cell? [1 mark] Number of cell divisions = 9 *09* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the 0 2 box . 4 In humans a fertilised egg cell contains 23 pairs of chromosomes. How many chromosomes will there be in each of the embryo cells? [1 mark] 0 2 . 5 Figure 4 represents a cell cycle for a human embryonic cell. Figure 4 Describe one change in the cell that occurs during each of the stages of the cell cycle. [3 marks] Stage 1 Stage 2 Stage 3 10 *10* IB/M/Jun22/8464/B/1H Do not write outside the Cell division is important in the growth of multicellular organisms. box 0 2 . 6 Figure 5 shows the mean height of boys and of girls from birth to age 18 years. Figure 5 11 *11* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 14 Compare the growth of boys with the growth of girls. Use data from Figure 5 in your answer. [6 marks] 0 2 . 7 Give one way that cell division by mitosis is important in fully grown animals. [1 mark] 12 *12* IB/M/Jun22/8464/B/1H Do not write outside the 0 3 Amylase is an enzyme that digests starch. box 0 3 . 1 Which organs in the human digestive system produce amylase? [1 mark] Tick () one box. Liver, small intestine and large intestine Salivary glands, stomach and liver Salivary glands, pancreas and small intestine Stomach, pancreas and large intestine A student investigated the effect of pH on the activity of amylase. This is the method used. 1. Prepare amylase solution at pH 5 2. Mix the amylase solution with starch in a boiling tube. 3. Remove a drop of the amylase-starch mixture every 30 seconds and test it for the presence of starch. 4. Record the time when all the starch has been digested. 5. Repeat steps 1 to 4 using amylase solution prepared at pH 6, then at pH 7 and then at pH 8 0 3 . 2 What was the independent variable in this investigation? [1 mark] 13 *13* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 0 3 . 3 Describe how the student would know when all the starch had been digested. [1 mark] 0 3 . 4 Figure 6 shows the student’s results. Figure 6 What was the optimum pH for the amylase? Use Figure 6. [1 mark] Optimum pH = 14 *14* IB/M/Jun22/8464/B/1H Do not write outside the A scientist did a different investigation. box This is the method used. 1. Prepare amylase solution at the optimum pH. 2. Mix the amylase solution with starch in a boiling tube. 3. Measure the concentration of sugar every 10 seconds for 2 minutes. Figure 7 shows the scientist’s results. Figure 7 0 3 . 5 How much time did it take for the amylase to digest all the starch? Use Figure 7. [1 mark] Time to digest all the starch