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Class notes Life Sciences (MetabolismofPurines1) Lehninger Principles of Biochemistry, ISBN: 9781464109621

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Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together.

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October 28, 2021
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Prof. maclaine sir
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Metabolism of Purines
Index
1.Sources of carbon and nitrogen
2.Synthesis of AMP and GMP
3.Synthesis of Di and Tri nucleotides
4.Can Cells Salvage Purines
5.Enzymes
6.Regulation
7.DEGRADATION OF PURINE
8.Purine Bases
9.Gout
10.Treatment

,Synthesis of Purines

, The formation of the purine bases is similar to the
pyrimidine bases via two pathways salvage and de novo

Sources of carbon and nitrogen

Gly gives C4 C5 and N7
Asp gives N1
Gln gives N3 and N9
N10 formyl THF
gives C2 and C8
CO2 gives C6
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