PATHOPHYSIOLOGY: HEMOTOLOGY
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Iron Deficient Anemia Labs - ANSWERLow serum ferritin
High red blood cell distribution width
Low serum iron level
High total iron-binding capacity
Thalassemia Labs - ANSWERHigh serum ferritin
Normal or increased red blood cell distribution width
Normal or increased serum iron level
Normal total iron-binding capacity
Characterized by the presence of large (macro), immature red blood cells
(megaloblasts) in the bone marrow and a decrease in the number of mature red blood
cells in circulation - ANSWERMegaloblastic Anemia
Often due to deficiencies in vitamin B12 (cobalamin) or folate (vitamin B9) -
ANSWERMegaloblastic Anemia
Risks of Megaloblastic Anemia - ANSWER-Dietary deficiencies: vegetarians, vegans;
those with poor nutritional intake
-Elderly
-Malabsorption syndromes (Celiac disease; Crohn's disease; Gastric bypass surgery)
-Pregnancy: due to increased nutritional needs
-Chronic alcohol abuse
Vitamin B-12 Deficiency - ANSWER•Fatigue
•Dyspnea
•Peripheral neuropathy in BLE (numbness and tingling)
What occur with Hemolytic Anemia - ANSWERRBCs are destroyed
Causes of Hemolytic Anemia include - ANSWER-Mismatched blood types-destroys
RBCs (Cytotoxic Type 2)
-Autoimmune hemolytic anemia due to autoantibodies against erythrocytes that the
immune system perceives as an antigen and then attacks it
-Allergic reaction to a drug causes drug-induced hemolytic anemia (drug-induced
hemolytic anemia).
What type of anemia is Sickle Cell Anemia - ANSWERhemolytic anemia