WGU D118 OA Adults in Primary Care
Comprehensive Resource To Help You Ace 2026-2027
Includes Frequently Tested Questions With ELABORATED
100% Correct COMPLETE SOLUTIONS
Guaranteed Pass First Attempt!!
Current Update!!
1. What type of inhibitors are tetracyclines classified as? - ANSWER
Bacteriostatic inhibitors of protein synthesis.
2. How do tetracyclines differ from aminoglycosides? - ANSWER
Tetracyclines are bacteriostatic, while aminoglycosides are bactericidal.
3. What is the primary use of tetracyclines? - ANSWER They are used
primarily for infections resistant to first-line agents.
4. What is the mechanism of action of tetracyclines? - ANSWER They
inhibit protein synthesis by binding to the 30S ribosomal subunit.
5. Why do tetracyclines have selective toxicity? - ANSWER They poorly
cross mammalian cell membranes, preventing harmful accumulation in host
cells.
,6. What types of bacteria are tetracyclines effective against? - ANSWER
They are broad-spectrum antibiotics active against various gram-positive
and gram-negative bacteria.
7. Name some sensitive organisms to tetracyclines. - ANSWER Rickettsia,
spirochetes, Brucella, Chlamydia, Mycoplasma, Helicobacter pylori, Borrelia
burgdorferi, Bacillus anthracis, and Vibrio cholerae.
8. What are the first-line uses of tetracyclines? - ANSWER Rickettsial
diseases, infections caused by Chlamydia trachomatis, brucellosis, cholera,
pneumonia caused by Mycoplasma pneumoniae, Lyme disease, anthrax,
and gastric infection with H. pylori.
9. How are tetracyclines used in the treatment of acne? - ANSWER They
are used topically and orally to suppress the growth of Propionibacterium
acnes.
10.What role do tetracyclines play in peptic ulcer disease? - ANSWER They
are used in combination with other drugs to eradicate H. pylori.
11.Which tetracyclines are used for periodontal disease? - ANSWER
Doxycycline and minocycline.
12.What is the benefit of oral doxycycline in periodontal disease? - ANSWER
It inhibits collagenase, an enzyme that destroys connective tissue in the
gums.
,13.How does food affect the absorption of tetracyclines? - ANSWER Food
can significantly decrease the absorption of tetracyclines.
14.What are common adverse effects of tetracyclines? - ANSWER
Gastrointestinal irritation, tooth discoloration, and potential superinfection.
15.What can happen if tetracyclines are taken by pregnant women? - ANSWER
They can cause staining of deciduous teeth in infants and suppress
growth of long bones in premature infants.
16.What is a superinfection? - ANSWER An overgrowth of drug-resistant
microbes due to suppression of drug-sensitive organisms.
17.How do tetracyclines affect the gastrointestinal tract? - ANSWER They
can cause epigastric burning, cramps, nausea, vomiting, and diarrhea.
18.What is the pharmacokinetic property of doxycycline? - ANSWER
Doxycycline has a high lipid solubility and is well absorbed (90-100%).
19.What is the half-life of minocycline? - ANSWER The half-life of
minocycline is approximately 11 to 23 hours.
, 20.What should tetracyclines not be administered with? - ANSWER Calcium
supplements, milk products, iron supplements, magnesium-containing
laxatives, and most antacids.
21.What is the effect of tetracyclines on teeth? - ANSWER They can cause
yellow or brown discoloration and hypoplasia of enamel.
22.What is the significance of the energy-dependent transport system for
tetracyclines? - ANSWER It allows tetracyclines to enter bacteria but not
mammalian cells.
23.What is the primary route of elimination for doxycycline? - ANSWER It is
eliminated via the gastrointestinal tract and urine.
24.What is the role of tetracyclines in treating Lyme disease? - ANSWER
They are used as a first-line treatment for Lyme disease.
How do tetracyclines suppress bacterial growth? - ANSWER By preventing the
addition of amino acids to the growing peptide chain.
What is the therapeutic use of tetracyclines in treating brucellosis? - ANSWER
Tetracyclines are used as a first-line treatment for brucellosis.
What is the effect of tetracyclines on collagenase? - ANSWER Doxycycline
inhibits collagenase, which helps in periodontal disease treatment.
Comprehensive Resource To Help You Ace 2026-2027
Includes Frequently Tested Questions With ELABORATED
100% Correct COMPLETE SOLUTIONS
Guaranteed Pass First Attempt!!
Current Update!!
1. What type of inhibitors are tetracyclines classified as? - ANSWER
Bacteriostatic inhibitors of protein synthesis.
2. How do tetracyclines differ from aminoglycosides? - ANSWER
Tetracyclines are bacteriostatic, while aminoglycosides are bactericidal.
3. What is the primary use of tetracyclines? - ANSWER They are used
primarily for infections resistant to first-line agents.
4. What is the mechanism of action of tetracyclines? - ANSWER They
inhibit protein synthesis by binding to the 30S ribosomal subunit.
5. Why do tetracyclines have selective toxicity? - ANSWER They poorly
cross mammalian cell membranes, preventing harmful accumulation in host
cells.
,6. What types of bacteria are tetracyclines effective against? - ANSWER
They are broad-spectrum antibiotics active against various gram-positive
and gram-negative bacteria.
7. Name some sensitive organisms to tetracyclines. - ANSWER Rickettsia,
spirochetes, Brucella, Chlamydia, Mycoplasma, Helicobacter pylori, Borrelia
burgdorferi, Bacillus anthracis, and Vibrio cholerae.
8. What are the first-line uses of tetracyclines? - ANSWER Rickettsial
diseases, infections caused by Chlamydia trachomatis, brucellosis, cholera,
pneumonia caused by Mycoplasma pneumoniae, Lyme disease, anthrax,
and gastric infection with H. pylori.
9. How are tetracyclines used in the treatment of acne? - ANSWER They
are used topically and orally to suppress the growth of Propionibacterium
acnes.
10.What role do tetracyclines play in peptic ulcer disease? - ANSWER They
are used in combination with other drugs to eradicate H. pylori.
11.Which tetracyclines are used for periodontal disease? - ANSWER
Doxycycline and minocycline.
12.What is the benefit of oral doxycycline in periodontal disease? - ANSWER
It inhibits collagenase, an enzyme that destroys connective tissue in the
gums.
,13.How does food affect the absorption of tetracyclines? - ANSWER Food
can significantly decrease the absorption of tetracyclines.
14.What are common adverse effects of tetracyclines? - ANSWER
Gastrointestinal irritation, tooth discoloration, and potential superinfection.
15.What can happen if tetracyclines are taken by pregnant women? - ANSWER
They can cause staining of deciduous teeth in infants and suppress
growth of long bones in premature infants.
16.What is a superinfection? - ANSWER An overgrowth of drug-resistant
microbes due to suppression of drug-sensitive organisms.
17.How do tetracyclines affect the gastrointestinal tract? - ANSWER They
can cause epigastric burning, cramps, nausea, vomiting, and diarrhea.
18.What is the pharmacokinetic property of doxycycline? - ANSWER
Doxycycline has a high lipid solubility and is well absorbed (90-100%).
19.What is the half-life of minocycline? - ANSWER The half-life of
minocycline is approximately 11 to 23 hours.
, 20.What should tetracyclines not be administered with? - ANSWER Calcium
supplements, milk products, iron supplements, magnesium-containing
laxatives, and most antacids.
21.What is the effect of tetracyclines on teeth? - ANSWER They can cause
yellow or brown discoloration and hypoplasia of enamel.
22.What is the significance of the energy-dependent transport system for
tetracyclines? - ANSWER It allows tetracyclines to enter bacteria but not
mammalian cells.
23.What is the primary route of elimination for doxycycline? - ANSWER It is
eliminated via the gastrointestinal tract and urine.
24.What is the role of tetracyclines in treating Lyme disease? - ANSWER
They are used as a first-line treatment for Lyme disease.
How do tetracyclines suppress bacterial growth? - ANSWER By preventing the
addition of amino acids to the growing peptide chain.
What is the therapeutic use of tetracyclines in treating brucellosis? - ANSWER
Tetracyclines are used as a first-line treatment for brucellosis.
What is the effect of tetracyclines on collagenase? - ANSWER Doxycycline
inhibits collagenase, which helps in periodontal disease treatment.
