Genetic Risk Factors Family history of bipolar disorder increases risk, with higher risk in primiparous
women
Manic Episode Recurrence Higher likelihood after a previous manic episode with psychotic features
Major Depressive Disorder May have hypomanic or manic symptoms, history of mania helps differentiate
from bipolar disorder
Bipolar II Disorder Differs from bipolar I by lack of past manic episodes
Substance-Induced Mania Manic symptoms due to substance use, must be distinguished from bipolar
disorder
ADHD Misdiagnosis Symptoms overlap with mania, careful diagnosis needed to differentiate
Personality Disorders Overlap with bipolar disorder symptoms, distinct episodes required for bipolar
diagnosis
Disruptive Mood Dysregulation Disorder More appropriate diagnosis for persistent severe irritability in children
Differential Diagnosis Process of distinguishing between similar disorders to reach a correct diagnosis
Generalized Anxiety Disorder Needs differentiation from bipolar disorder, careful history helps in diagnosis
Posttraumatic Stress Disorder Symptoms need to be distinguished from bipolar disorder, episodic nature is
crucial
Substance/medication-induced bipolar disorder Manic symptoms induced by substances/medications, distinguishable from
bipolar I disorder
Attention-deficit/hyperactivity disorder (ADHD) Misdiagnosed as bipolar disorder, symptoms overlap with mania
Personality disorders Overlap with bipolar disorders, require distinct episodes for diagnosis
Disorders with prominent irritability Careful diagnosis of bipolar disorder in individuals with clear episodes of mania
Bipolar I disorder Criteria for major depressive episodes, distinct from bipolar II disorder
Depressive episodes Symptoms and criteria for major depressive episodes in bipolar I disorder
Bipolar II disorder Characteristics, diagnosis, and differences from bipolar I disorder
Cyclothymic Disorder Criteria for hypomanic and depressive symptoms over a period
Major depression in children DSM-5 criteria for diagnosing major depression in children and adolescents
Irritable mood in youth Common presentation of major depressive disorder in children and adolescents
women
Manic Episode Recurrence Higher likelihood after a previous manic episode with psychotic features
Major Depressive Disorder May have hypomanic or manic symptoms, history of mania helps differentiate
from bipolar disorder
Bipolar II Disorder Differs from bipolar I by lack of past manic episodes
Substance-Induced Mania Manic symptoms due to substance use, must be distinguished from bipolar
disorder
ADHD Misdiagnosis Symptoms overlap with mania, careful diagnosis needed to differentiate
Personality Disorders Overlap with bipolar disorder symptoms, distinct episodes required for bipolar
diagnosis
Disruptive Mood Dysregulation Disorder More appropriate diagnosis for persistent severe irritability in children
Differential Diagnosis Process of distinguishing between similar disorders to reach a correct diagnosis
Generalized Anxiety Disorder Needs differentiation from bipolar disorder, careful history helps in diagnosis
Posttraumatic Stress Disorder Symptoms need to be distinguished from bipolar disorder, episodic nature is
crucial
Substance/medication-induced bipolar disorder Manic symptoms induced by substances/medications, distinguishable from
bipolar I disorder
Attention-deficit/hyperactivity disorder (ADHD) Misdiagnosed as bipolar disorder, symptoms overlap with mania
Personality disorders Overlap with bipolar disorders, require distinct episodes for diagnosis
Disorders with prominent irritability Careful diagnosis of bipolar disorder in individuals with clear episodes of mania
Bipolar I disorder Criteria for major depressive episodes, distinct from bipolar II disorder
Depressive episodes Symptoms and criteria for major depressive episodes in bipolar I disorder
Bipolar II disorder Characteristics, diagnosis, and differences from bipolar I disorder
Cyclothymic Disorder Criteria for hypomanic and depressive symptoms over a period
Major depression in children DSM-5 criteria for diagnosing major depression in children and adolescents
Irritable mood in youth Common presentation of major depressive disorder in children and adolescents
