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,Question 1
Polyene: amphotericin b (Abelcet)
Correct Answer
Antifungal: systemic mycoses
Question 2
Polyene: amphotericin b (Abelcet) - Mechanism of Action
Correct Answer
Binds to components of the fungal cell membrane-increasing permeability. This results in intracellular leakage,
which reduces the organism's viability.
Question 3
Polyene: amphotericin b (Abelcet) - Adverse Effects
Correct Answer
(Intrathecal) Infusion reactions, Nephrotoxicity, hypokalemia, Hematologic effects
Question 4
Polyene: amphotericin b (Abelcet) - Precautions
Correct Answer
Renal Impairment
Question 5
Polyene: amphotericin b (Abelcet) - Interactions
Correct Answer
Other nephrotoxic meds, flucytosine
Question 6
Polyene: amphotericin b (Abelcet) - Education
Correct Answer
IV administration
Question 7
Polyene: amphotericin b (Abelcet) - Labs
Correct Answer
BMP, CBC
Question 8
Azoles: itraconazole (Sporanox)
Correct Answer
Antifungal: broad spectrum fungal pathogens
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, Question 9
Azoles: itraconazole (Sporanox) - Mechanism of Action
Correct Answer
Inhibits the synthesis of ergosterol (sterol), resulting in increased membrane permeability and leakage of cellular
components.
Question 10
Azoles: itraconazole (Sporanox) - Adverse Effects
Correct Answer
GI upset, Cardiac suppression, Hepatic injury
Question 11
Azoles: itraconazole (Sporanox) - Precautions
Correct Answer
Hepatic dysfunction, Heart failure
Question 12
Azoles: itraconazole (Sporanox) - Interactions
Correct Answer
PPIs, CYP3A4 inhibitors
Question 13
Azoles: itraconazole (Sporanox) - Education
Correct Answer
Take with food/cola
Question 14
Azoles: itraconazole (Sporanox) - Labs
Correct Answer
BMP, Coagulation, Serum Drug Levels
Question 15
Echinocandins: caspofungin (Cancidas)
Correct Answer
Antifungal: aspergillus and candida infections
Question 16
Echinocandins: caspofungin (Cancidas) - Mechanism of Action
Correct Answer
Inhibits the biosynthesis of beta-1,3-d-glucan, an essential fungal cell wall component.
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