Page 1 of 78
“NAPLEX REVIEW QUESTIONS & ANSWERS
EXAM 2026 ”LATEST EXAM 2026 – 2027 SOLVED
QUESTIONS & ANSWERS VERIFIED 100%
GRADED A+ (LATEST VERSION) WELL REVISED
100% GUARANTEE PASS
Naplex Review Questions
A 24-year-old female comes to the pharmacy health clinic with symptoms of
nasal congestion, runny nose, and a feeling of pressure in her face for the past
5 days. The nasal drainage is described as yellow and thin. The patient has no
fever, cough, shortness of breath. sore throat, myalgia, or headache. She has
been using OTC decongestants but is asking for an antibiotic to accelerate
resolution of her symptoms.
Which of the following treatments is recommended for this patient at this
time?
A. Amoxicillin
B. Azithromycin
C. Cefdinir
, Page 2 of 78
D. Doxycycline
E. Symptomatic relief only
Symptomatic relief only
(consider antibiotics after 7-10 days)
JP is a 42-year-old male who comes to the urgent care clinic because of a
"rash" on his right lower leg. He states that he first noticed an area of redness
above his ankle approximately 4 days ago that has spread up the front of his
shin. The patient reports no trauma to the area and has no fever, chills, or
malaise.
Which empiric antibiotic should be recommended for this patient?
A. Amoxicillin
B. Cephalexin
C. Ciprofloxacin
D. Clarithromycin
E. Metronidazole
Cephalexin
(Group A strep; non-purulent)
SD IS a 48-year-old female preparing to start Humira for rheumatoid arthritis.
Required pre-treatment screening for latent tuberculosis (IB) reveals a positive
Interferon-gamma release assay. A chest x-ray is negative. and the patient
reports no signs or symptoms of active pulmonary TB.
Which treatment should this patent initiate before starting Humira?
A. Isoniazid monotherapy daily x 3 months
B. Isoniazid + rifampin daily x 3 months
C. Isoniazid + rifapentine weekly x 9 months
D. Rifampin monotherapy daily x 9 months
E. Rifampin + pyrazinamide weekly x 3 months
Isoniazid + rifampin daily x 3 months
, Page 3 of 78
A 68-year-old male comes to the emergency department with an 8-day history
of fever, chills, and malaise. Four weeks ago, he underwent a tooth extraction.
Which organism will most likely be identified on the blood culture?
A. H. influenzae
B. Listeria monocytogenes
C. S. aureus
D. S. epidermidis
E. Viridans streptococci
Viridans streptococci
A 13-year-old male visits his primary care provider with symptoms of sudden-
onset sore throat, chills, and headache. He does not have a cough or runny
nose. He is found to have a temperature of 101°F (38.3°C). inflamed tonsils
with patchy exudates, and swollen lymph nodes in the neck. A rapid antigen
swab of the throat is positive for Streptococcus pyogenes. He has no known
drug allergies.
Which of the following is a first-line treatment for this patient?
A. Amoxicillin/clavulanate
B. Erythromycin
C. Levofloxacin
D. Penicillin V potassium
E. Symptomatic treatment only
Penicillin V potassium
(NOT augmentin because it is too broad; could also use amoxicillin)
Empiric antibiotics and steroids have been ordered for a 45-year-old patient
with suspected community-acquired bacterial meningitis. Cultures and a
lumbar puncture are pending.
If antibiotics are expected to be administered at 1400, which of the following is
correct regarding the selection and timing of steroids in this patient?
A. Dexamethasone, administer at 1400
B. Dexamethasone, administer at 1500
C. Prednisone, administer at 1400
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D. Prednisone, administer at 1500
E. Steroids are not indicated for bacterial meningitis
Dexamethasone, administer at 1400
TM is a 32-year-old male who comes to his primary care physician with
symptoms of thick, yellow-green nasal discharge, nasal "stuffiness," and a
feeling of pressure in his face and ears. He also describes more frequent
headaches. The patient initially thought he had a cold and self-treated with
OTC medications, but his condition worsened and has persisted for
approximately 12 days. TM has no known drug allergies. A decision is made to
prescribe antibiotics.
Which of the following is a first-line treatment for TM's condition?
A. Amoxicillin/clavulanate
B. Clarithromycin
C. Clindamycin
D. Levofloxacin
E. Trimethoprim-sulfamethoxazole
Amoxicillin/clavulanate
JB is a 72-year-old male who is due for his tetanus vaccine. He lives in an
apartment with his daughter, a 3-month-old granddaughter, and a 2-year-old
grandson. He does not know if he ever received the pertussis vaccine.
Which vaccine should JB receive?
A. Td
B. Tdap
C. TdP
D. Tetanus only
E. DTaP
Tdap
CM is a 29-year-old sexually active male who comes to the emergency
department after finding a painless, 2-cm ulcer on his penis. He does not have
a fever or urethral discharge but discloses that he currently engages in
“NAPLEX REVIEW QUESTIONS & ANSWERS
EXAM 2026 ”LATEST EXAM 2026 – 2027 SOLVED
QUESTIONS & ANSWERS VERIFIED 100%
GRADED A+ (LATEST VERSION) WELL REVISED
100% GUARANTEE PASS
Naplex Review Questions
A 24-year-old female comes to the pharmacy health clinic with symptoms of
nasal congestion, runny nose, and a feeling of pressure in her face for the past
5 days. The nasal drainage is described as yellow and thin. The patient has no
fever, cough, shortness of breath. sore throat, myalgia, or headache. She has
been using OTC decongestants but is asking for an antibiotic to accelerate
resolution of her symptoms.
Which of the following treatments is recommended for this patient at this
time?
A. Amoxicillin
B. Azithromycin
C. Cefdinir
, Page 2 of 78
D. Doxycycline
E. Symptomatic relief only
Symptomatic relief only
(consider antibiotics after 7-10 days)
JP is a 42-year-old male who comes to the urgent care clinic because of a
"rash" on his right lower leg. He states that he first noticed an area of redness
above his ankle approximately 4 days ago that has spread up the front of his
shin. The patient reports no trauma to the area and has no fever, chills, or
malaise.
Which empiric antibiotic should be recommended for this patient?
A. Amoxicillin
B. Cephalexin
C. Ciprofloxacin
D. Clarithromycin
E. Metronidazole
Cephalexin
(Group A strep; non-purulent)
SD IS a 48-year-old female preparing to start Humira for rheumatoid arthritis.
Required pre-treatment screening for latent tuberculosis (IB) reveals a positive
Interferon-gamma release assay. A chest x-ray is negative. and the patient
reports no signs or symptoms of active pulmonary TB.
Which treatment should this patent initiate before starting Humira?
A. Isoniazid monotherapy daily x 3 months
B. Isoniazid + rifampin daily x 3 months
C. Isoniazid + rifapentine weekly x 9 months
D. Rifampin monotherapy daily x 9 months
E. Rifampin + pyrazinamide weekly x 3 months
Isoniazid + rifampin daily x 3 months
, Page 3 of 78
A 68-year-old male comes to the emergency department with an 8-day history
of fever, chills, and malaise. Four weeks ago, he underwent a tooth extraction.
Which organism will most likely be identified on the blood culture?
A. H. influenzae
B. Listeria monocytogenes
C. S. aureus
D. S. epidermidis
E. Viridans streptococci
Viridans streptococci
A 13-year-old male visits his primary care provider with symptoms of sudden-
onset sore throat, chills, and headache. He does not have a cough or runny
nose. He is found to have a temperature of 101°F (38.3°C). inflamed tonsils
with patchy exudates, and swollen lymph nodes in the neck. A rapid antigen
swab of the throat is positive for Streptococcus pyogenes. He has no known
drug allergies.
Which of the following is a first-line treatment for this patient?
A. Amoxicillin/clavulanate
B. Erythromycin
C. Levofloxacin
D. Penicillin V potassium
E. Symptomatic treatment only
Penicillin V potassium
(NOT augmentin because it is too broad; could also use amoxicillin)
Empiric antibiotics and steroids have been ordered for a 45-year-old patient
with suspected community-acquired bacterial meningitis. Cultures and a
lumbar puncture are pending.
If antibiotics are expected to be administered at 1400, which of the following is
correct regarding the selection and timing of steroids in this patient?
A. Dexamethasone, administer at 1400
B. Dexamethasone, administer at 1500
C. Prednisone, administer at 1400
, Page 4 of 78
D. Prednisone, administer at 1500
E. Steroids are not indicated for bacterial meningitis
Dexamethasone, administer at 1400
TM is a 32-year-old male who comes to his primary care physician with
symptoms of thick, yellow-green nasal discharge, nasal "stuffiness," and a
feeling of pressure in his face and ears. He also describes more frequent
headaches. The patient initially thought he had a cold and self-treated with
OTC medications, but his condition worsened and has persisted for
approximately 12 days. TM has no known drug allergies. A decision is made to
prescribe antibiotics.
Which of the following is a first-line treatment for TM's condition?
A. Amoxicillin/clavulanate
B. Clarithromycin
C. Clindamycin
D. Levofloxacin
E. Trimethoprim-sulfamethoxazole
Amoxicillin/clavulanate
JB is a 72-year-old male who is due for his tetanus vaccine. He lives in an
apartment with his daughter, a 3-month-old granddaughter, and a 2-year-old
grandson. He does not know if he ever received the pertussis vaccine.
Which vaccine should JB receive?
A. Td
B. Tdap
C. TdP
D. Tetanus only
E. DTaP
Tdap
CM is a 29-year-old sexually active male who comes to the emergency
department after finding a painless, 2-cm ulcer on his penis. He does not have
a fever or urethral discharge but discloses that he currently engages in
