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Exam (elaborations)

ANCC PMHNP Exam Prep (2026) – 19 Case-Based Questions on Pharmacology, Diagnosis, Safety, Ethics | NRNP 6665 | Walden University

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This document provides 19 advanced clinical scenario-based questions and answers tailored for the 2026 ANCC Psychiatric-Mental Health Nurse Practitioner (PMHNP) board certification exam. Aligned with the NRNP 6665: PMHNP Care Across the Lifespan course at Walden University, the questions reflect real-world complexity and are fully explained with up-to-date clinical rationales. Key topics covered include: Psychopharmacology (e.g., clozapine safety, lithium monitoring, MAOI interactions, antipsychotic-induced adverse effects) Diagnostic reasoning for conditions like schizophrenia, bipolar disorder, PTSD, and dementia Safety protocols, lab interpretation, and medication contraindications (e.g., QTc prolongation, agranulocytosis, SSRI discontinuation syndrome) Ethics in prescribing and medication misuse Neurobiology of psychiatric conditions (e.g., dopamine pathways, serotonin receptors) Psychotherapy and therapeutic communication in trauma care Each question is designed to reinforce clinical reasoning, board-level knowledge, and ethical decision-making—making this an essential study resource for PMHNP candidates, nurse practitioner students, and advanced clinical nursing courses. Who this is for: PMHNP students at Walden University or equivalent programs Students in Advanced Psychiatric Nursing, Psychopharmacology, or Mental Health Diagnosis courses NP graduates preparing for the ANCC PMHNP certification exam Mental health professionals seeking structured review of clinical scenarios This resource is particularly useful for reinforcing board-level application of content through case-based formats, suitable for solo study, tutoring, or exam coaching. Keywords: PMHNP exam, NRNP 6665, ANCC 2026, psychiatric nurse practitioner, clinical case questions, psychopharmacology, SSRI syndrome, clozapine monitoring, lithium safety, dopamine pathways, atypical antipsychotics, neuroleptic malignant syndrome, schizophrenia treatment, ethical prescribing, QTc prolongation, therapeutic communication, Walden University

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Uploaded on
January 21, 2026
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Written in
2025/2026
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ANCC Review Questions (PMHNP IQ)
2026 Exam Questions and Answers |
100% Solved



What direct-acting dopamine receptor agonist is recommended to be used

in the treatments of neuroleptic malignant syndrome (NMS) fo help lower

the dopamine blockade?




A) benzotropine (Cogentin)

B) bromocriptine (Parlodel)

C) dantrolene (Dantrium)

,D) trihexyphenidyl (Artane) - 🧠 ANSWER ✔✔A) Bromocriptine (Parlodel) is

the recommended direct acting dopamine receptor agonist to help

decrease the dopamine blockade. Danrolene (Dantrium) is a muscle

relaxant. Benzotropine (Cogentin) and Trihexyphenidyl (Artane) are

anticholinergic medications used for extrapyramidal side effects (EPS).

Mr. Smith is a 56 year old white male who has been successfully treated on

Selegiline for over 4 years. Mr. Smith is going in for elective surgical

procedure. Which medication is strictly contraindicated with Selegiline?




A) Non-steroidal anti-inflammatory drugs (NSAIDS)

B) Codeine

C) Morphine


D) Meperidine - 🧠 ANSWER ✔✔D) Meperidine is strictly prohibited when a

patient is treated on a monoamine oxidase inhibitor (MAOI) due to the risk

of hypertensive crisis and death.

A WBC of 4,000 in a patient taking Clozapine would prompt the PMHNP to

take which of the following actions?

, A) Consult with hematologist to determine appropriate antibiotic regimen

and monitor closely.

B) Institute twice-weekly complete blood count with differentials and

monitor closely.

C) Discontinue clozapine, initiate alternative antipsychotic medication and

monitor closely.

D) Institute daily complete blood count with differentials and monitor

closely. - 🧠 ANSWER ✔✔B) Institute twice-weekly complete blood count

with differentials and monitor closely.




The recommended cut-points for discontinuation of clozapine are WBC of

2,000 to 3,000 or granulocytes of 1,000 to 1,500 for agranulocytosis and

severely compromised immune system. At a WBC of 4,000, the

recommendation is to closely monitor CBC with differential twice a week

while patient may continue clozapine in the absence of any other signs or

symptoms.

A patient with a diagnosis of schizophrenia has a history of suicidal ideation

and suicide attempts. The PMHNP should consider which antipsychotic



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