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Clayton Chapter 1-48
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TABLE OF CONTENTS. k k
Unit 1: Applying Pharmacology to Nursing Practice
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Chapter 1: Drug Definitions, Standards, and Information Sources
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Chapter 2: Basic Principles of Drug Action and Drug Interactions
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Chapter 3: Drug Action Across the Life Span
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Chapter 4: The Nursing Process and Pharmacology
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Chapter 5: Patient Education to Promote Health
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Unit 2: Illustrated Atlas of Medication Administration
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Chapter 6: Principles of Medication Administration and Medication Safety Chapter
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7: Percutaneous Administration
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Chapter 8: Enteral Administration k k k
Chapter 9: Parenteral Administration: Safe Preparation of Parenteral Medications
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Chapter 10: Parenteral Administration: Intradermal, Subcutaneous, and Intramuscular
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Routes
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Chapter 11: Parenteral Administration: Intravenous Route
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Unit 3: Drugs Affecting the Autonomic and Central Nervous Systems
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Chapter 12: Drugs Affecting the Autonomic Nervous System Chapter
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13: Drugs Used for Sleep
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Chapter 14: Drugs Used for Neurodegenerative Disorders (NEW!)
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Chapter 15: Drugs Used for Anxiety Disorders
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Chapter 16: Drugs Used for Depressive and Bipolar Disorders
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Chapter 17: Drugs Used for Psychoses
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Chapter 18: Drugs Used for Seizure Disorders
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Chapter 19: Drugs Used for Pain Management
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kUnit 4: Drugs Affecting the Cardiovascular System
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Chapter 20: Introduction to Cardiovascular Disease and Metabolic Syndrome
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Chapter 21: Drugs Used to Treat Dyslipidemias
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Chapter 22: Drugs Used to Treat Hypertension
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Chapter 23: Drugs Used to Treat Dysrhythmias
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Chapter 24: Drugs Used to Treat Angina Pectoris
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Chapter 25: Drugs Used to Treat Peripheral Vascular Disease
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Chapter 26: Drugs Used to Treat Thromboembolic Disorders
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Chapter 27: Drugs Used to Treat Heart Failure
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Chapter 28: Drugs Used for Diuresis k k k k k
Unit 5: Drugs Affecting the Respiratory System
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Chapter 29: Drugs Used to Treat Upper Respiratory Disease
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Chapter 30: Drugs Used to Treat Lower Respiratory Disease
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Unit 6: Drugs Affecting the Digestive System
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Chapter 31: Drugs Used to Treat Oral Disorders
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Chapter 32: Drugs Used to Treat Gastroesophageal Reflux and Peptic Ulcer Disease
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Chapter 33: Drugs Used to Treat Nausea and Vomiting
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Chapter 34: Drugs Used to Treat Constipation and Diarrhea
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Unit 7: Drugs That Affect the Endocrine System
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Chapter 35: Drugs Used to Treat Diabetes Mellitus
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Chapter 36: Drugs Used to Treat Thyroid Disease
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Chapter 37: Corticosteroids
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Chapter 38: Gonadal Hormones k k k
Unit 8: Drugs Affecting the Reproductive System
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Chapter 39: Drugs Used in Obstetricsk k k k k
Chapter 40: Drugs Used in Men‘s and Women‘s Health
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Unit 9: Drugs Affecting Other Body Systems
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Chapter 41: Drugs Used to Treat Disorders of the Urinary System
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Chapter 42: Drugs Used to Treat Glaucoma and Other Eye Disorders
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Chapter 43: Drugs Used to Treat Cancer
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Chapter 44: Drugs Used to Treat the Musculoskeletal System
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Chapter 45: Drugs Used to Treat Infection Unit 10: Drugs Affecting the General Health of the Body
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Chapter 46: Nutrition
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Chapter 47: Herbal and Dietary Supplemental Therapy Chapter
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48: Substance Abuse
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,Chapter 01: Drug Definitions, Standards, and Information Sources
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Willihnganz: Clayton’s Basic Pharmacology for Nurses, 18th Edition
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MULTIPLE CHOICE k
1. What is the name under which a drug is listed by the US Food and Drug
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Administration (FDA)?
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a.Brand
b.Nonproprietary
c.Official
d.Trademark
ANS: C k
The official name is the name under which a drug is listed by the FDA.
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The brand name, or trademark, is the name given to a drug by its
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manufacturer. The nonproprietary, or generic, name is provided by the
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United States Adopted Names Council.
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DIF: Cognitive Level: Knowledge REF: p. 2 OBJ: 1 k k k k k
NAT:NCLEXClient NeedsCategory: Safe, Effective Care Environment
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TOP:NursingProcess Step: Assessment
k CON: Patient Education k k k k
2. Which source contains information specific to nutritional supplements?
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a. USP Dictionary of USAN & International Drug Names
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b. Natural Medicines Comprehensive Database k k k
c. United States Pharmacopoeia/National Formulary (USP NF)
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d. Drug Interaction Facts k k
ANS: C k
United States Pharmacopoeia/National Formulary contains information specific to nutritional
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supplements. USP Dictionary of USAN & International Drug Names is a compilation of drug
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names, pronunciation guide, and possible future FDA approved drugs; it does not include
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nutritional supplements. Natural Medicines Comprehensive Database contains evidence-based
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information on herbal medicines and herbal combination products; it does not include information
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specific to nutritional supplements. Drug Interaction Facts contains comprehensive information on
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drug interaction facts; it does not include nutritional supplements.
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DIF: Cognitive Level: Knowledge REF: p. 2 | p. 3 OBJ: 3 k k k k k k k k
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Assessment
k CON: Nutrition | Patient Education k k k k k k
3. What is the most comprehensive reference available to research a drug interaction?
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a. Drug Facts and Comparisons k k k
b. Drug Interaction Facts k k
c. Handbook on Injectable Drugs k k k
d. Martindale—The Complete Drug Reference k k k
, ANS: B k
First published in 1983, Drug Interaction Facts is the most comprehensive book available on drug
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interactions. In addition to monographs listing various aspects of drug interactions, this
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information is reviewed and updated by an internationally renowned group of physicians and
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pharmacists with clinical and scientific expertise.
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DIF: Cognitive Level: Comprehension REF: p. 4 OBJ: 3 k k k k k
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Assessment CON: Safety | Patient Education | Clinical Judgment k k k k k k k k k
4. The physician has written an order for a drug with which the nurse is unfamiliar. Which section of
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the Physicians’ Desk Reference (PDR) is most helpful to get information about this drug?
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a. Manufacturer‘s section k
b. Brand and Generic name section k k k k
c. Product category section k k
d. Product information section k k
ANS: B k
A physician‘s order would include the brand and/or generic name of the drug. The alphabetic
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index in the PDR would make this section the most user-friendly. Based on a physician‘s order,
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manufacturer‘s information and classification information would not be known. The
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Manufacturer‘s section is a roster of manufacturers. The product category section lists products
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subdivided by therapeutic classes, such as analgesics, laxatives, oxytocics, and antibiotics. The
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product information section contains reprints of the package inserts for the major products of
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manufacturers.
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DIF: Cognitive Level: Comprehension REF: p. 4 OBJ: 3 k k k k k
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Planning CON: Safety | Patient Education | Clinical Judgment k k k k k k k k k
5. Which online drug reference makes available to healthcare providers and the public a standard,
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comprehensive, up-to-date look up and downloadable resource about medicines?
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a. American Drug Index k k
b. American Hospital Formulary k k
c. DailyMed
d. Physicians’ Desk Reference (PDR) k k k
ANS: C k
DailyMed makes available to healthcare providers and the public a standard, comprehensive, up-
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to-date look up and downloadable resource about medicines. The American Drug Index is not
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appropriate for patient use. The American Hospital Formulary is not appropriate for patient use.
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The PDR is not appropriate for patient use.
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DIF: Cognitive Level: Knowledge REF: p. 3 | p. 5 k k k k k k k OBJ: 4 k
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Implementation
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CON: Safety | Patient Education | Clinical Judgment
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6. Which legislation authorizes the FDA to determine the safety of a drug before its marketing?
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, a. Federal Food, Drug, and Cosmetic Act (1938) k k k k k k
b. Durham Humphrey Amendment (1952) k k k
c. Controlled Substances Act (1970) k k k
d. Kefauver Harris Drug Amendment (1962) k k k k
ANS: A k
The Federal Food, Drug, and Cosmetic Act of 1938 authorized the FDA to determine the safety of
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all drugs before marketing. Later amendments and acts helped tighten FDA control and ensure drug
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safety. The Durham Humphrey Amendment defines the kinds of drugs that cannot be used safely
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without medical supervision and restricts their sale to prescription by a licensed practitioner. The
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Controlled Substances Act addresses only controlled substances and their categorization. The
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Kefauver Harris Drug Amendment ensures drug efficacy and greater drug safety. Drug
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manufacturers are required to prove to the FDA the effectiveness of their products before
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marketing them.
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DIF: Cognitive Level: Knowledge REF: p. 5 k k k k OBJ: 6 k
NAT:NCLEXClient NeedsCategory: Physiological Integrity
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TOP:NursingProcess Step: Assessment
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CON: Safety | Patient Education | Evidence | Health Care Law
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7. Meperidine (Demerol) is a narcotic with a high potential for physical and psychological
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dependency. Under which classification does this drug fall?
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a. I
b. II
c. III
d. IV
ANS: B k
Meperidine (Demerol) is a Schedule II drug; it has a high potential for abuse and may lead to
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severe psychological and physical dependence. Schedule I drugs have high potential for abuse
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and no recognized medical use. Schedule III drugs have some potential for abuse. Use may lead to
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low to moderate physical dependence or high psychological dependence. Schedule IV drugs have
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low potential for abuse. Use may lead to limited physical or psychological dependence.
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DIF: Cognitive Level: Comprehension REF: p. 5 OBJ: 2 k k k k k
NAT:NCLEXClient NeedsCategory: Safe, Effective Care Environment
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TOP:NursingProcess Step: Assessment
k CON: Patient Education | Addiction | Pain k k k k k k k k
8. What would the FDA do to expedite drug development and approval for an outbreak of
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ksmallpox, for which there is no known treatment?
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a. List smallpox as a health orphan disease.
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b. Omit the preclinical research phase.
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c. Extend the clinical research phase. k k k k
d. Fast track the investigational drug.
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ANS: D k