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HESI A2 Anatomy and Physiology Study Guide (2026 Latest Update) – Comprehensive Practice Questions, Detailed Explanations & Exam-Focused Review for Guaranteed Nursing School Admission Success

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The HESI A2 Anatomy and Physiology Study Guide is a comprehensive, exam-focused resource designed to help students confidently pass the HESI Admission Assessment (A2) A&P section on the first attempt. This guide is updated to align with the latest HESI A2 exam blueprint, ensuring accurate coverage of all tested body systems and concepts. This study guide provides in-depth review and practice questions covering cell structure and function, tissues and membranes, skeletal system, muscular system, nervous system, cardiovascular system, respiratory system, digestive system, urinary system, endocrine system, and reproductive system. Content is presented in a clear, easy-to-understand format, making complex anatomy and physiology topics manageable and exam-ready. Included are realistic HESI-style questions with verified correct answers, helping students strengthen critical thinking, improve recall, and build testing confidence. This resource is ideal for self-study, last-minute revision, and repeated practice, making it a valuable companion to textbooks, online courses, and classroom instruction. Perfect for students applying to nursing programs, practical nursing (PN/LPN), registered nursing (RN), radiologic technology, respiratory therapy, and allied health programs, this HESI A2 Anatomy and Physiology guide is designed to maximize scores and increase acceptance chances into competitive healthcare programs.

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Uploaded on
January 9, 2026
Number of pages
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Written in
2025/2026
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HESI A2 ANATOMY AND PHYSIOLOGY
1. What is histology?

Answer The study of tissues


2. What is a tissue?

Answer A group of cells that act together to perform a specific function.


3. What are the fundamental tissues?

Answer Epithelial Connective

Muscle

Nerve

(Elephants Can Make News)


4. What is the function of epithelial cells?

Answer Cover, line, and protect the body and the internal organs.


5. What is the function of connective tissue?

Answer Framework of the body. Provides support and structure to organs.

6. What is neuroglia?


, Answer The neurons and connective tissue cells that compose nerve tissue.


7. What ability does muscle tissue have?

Answer Ability to contract and shorten.


8. What is muscle tissue classified as?

Answer Voluntary(skeletal muscles) and involuntary(smooth & cardiac)


9. What is meiosis?

Answer The cell division that takes place in the gonads, i.e. the ovaries and testes.


10. What two layers compose the skin?

Answer Epidermis and dermis.


11. What is the epidermis?

Answer The outermost protective layer of dead keratinized epithelial cells.


12. What is the dermis?

Answer The underlying layer of connective tissue with blood vessels, nerve endings, and the associated

skin tissues.

13. What are the layers of the epidermis?



,Answer Corneum Lucidum

Granulosum


Germivatum ( basale & spinosum)

Mnemonic

Answer Candy Lions Growl Great.

14. What does the protein pigment melanin protect against?

Answer Radiation from the Sun


15. What is the dermis composed of?

Answer Fibrous connective tissue with nerve endings, blood vessels, sensory nerve endings, hair

follicles, and glands.

16. What are the 2 types of sweat glands?

Answer ecrine & apocrine


17. What do ecrine sweat glands produce?

Answer Sweat. Regulate body temperature.


18. What do apocrine sweat glands produce?



, Answer Secretions contain bits of cytoplasm from cells, attracting bacteria that produces body odor.

19. What do sebaceous glands secrete?

Answer They secrete sebum through the hair follicles, which lubricates the skin and prevents

drying.

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