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HESI Pharmacology Practice Test – Comprehensive NCLEX-Style Questions & Verified Answers for Nursing Students | HESI A2 & Exit Exam Prep (Complete Exam Material)

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This document contains a full-length HESI Pharmacology practice test with over 70 NCLEX-style multiple-choice questions, each paired with clearly indicated correct answers. The questions comprehensively cover core pharmacology topics including medication mechanisms of action, side effects, contraindications, drug interactions, nursing interventions, and patient education. The practice test spans a wide range of systems such as cardiovascular, neurological, endocrine, gastrointestinal, respiratory, psychiatric, infectious disease, oncology, and maternal-child pharmacology. It is ideal for HESI A2, HESI Exit Exam, NCLEX-RN, and general nursing pharmacology revision. This resource is especially useful for students who want realistic exam-level questions to test knowledge, identify weak areas, and improve clinical judgment before high-stakes nursing exams.

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Uploaded on
January 2, 2026
Number of pages
57
Written in
2025/2026
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Exam (elaborations)
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HESI PHARMACOLOGY
PRACTICE TEST
1. The nurse reviews the new prescription, phenelzine (Nardil), a monoamine


oxidase inhibitor (MAOI), for a client with depression on the psychiatric unit.


Which information is most important for the nurse to assess?



A. Consumption of any alcohol or tyramine rich foods


B. Reports of nausea or vomiting


C. Therapeutic serum drug levels


D. Blood pressure and pulse prior to taking each dose


Answer A


2. The nurse is administering haloperidol 0.5 mg IM PRN to a client for the first


time. What side effects should the nurse assess thr client during the initial


dose?





,A. Bradykinesia


B. Dystonia


C. Somatization


D. Akathisia


Answer B


3. While reviewing the client's electronic medical record (EMR), the nurse as-

sesses a client who is at risk for a possible interaction with an over-the-counter


(OTC) decongestant. Which client health history should the nurse report to the


health care provider concerning the OTC medication? (Select all that apply)



A. Type 1 diabetes mellitus (DM)


B. Closed angle glaucome


C. Chronic hypertension


D. Rheumatoid arthritis


E. Crohn's disease



, Answer B,C


4. A client prescribed ipratropium reports nausea, blurred vision, headaches,


and insomnia after using the inhaler. Which action should the nurse implement


first?



A. Withhold the medication and report symptoms and vital signs to the health-


care provider






, B. Give PRN medication for nausea and vomiting and evaluate client in 30


minutes


C. reassure client that the ipratropium given will alleviate the symptoms


D. Delay administration of ipratropium until the next maintenance medication


is scheduledAnswer A


5. A client diagnosed with multiple sclerosis is experiencing profound weakness,


blurry vision, and shooting pains in both legs. Which medication is considered


the best course of treatment for the nurse to administer?



A. High dose methylprednisolone intravenously


B. Baclofen three times a day


C. Broad spectrum antibiotic coverage orally


D. Immunomodulatory drug therapy periodically


Answer A


6. The nurse administers 30 mL of lactulose for a client with stage 2 hepatic
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