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HESI Pharmacology Exit Exam – Complete Questions and Answers for LPN/LVN & RN Students | High-Yield Drug Class Review, Safety, Side Effects & Nursing Priorities

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This document is an in-depth and exam-focused study resource created specifically for students preparing for the HESI Pharmacology Exit Exam. It provides a structured collection of high-yield questions and accurate answers that reflect the format, difficulty, and clinical focus of the actual HESI exam. The content emphasizes critical pharmacology concepts that nursing students are expected to master before program completion. The study guide covers a wide range of essential topics, including major drug classes, mechanisms of action, therapeutic uses, side effects, adverse reactions, contraindications, drug interactions, and priority nursing interventions. Special attention is given to medication safety, dosage considerations, patient education, and common pharmacology scenarios tested on HESI exams. The questions are designed to strengthen clinical reasoning, reinforce safe medication administration practices, and improve exam performance. This resource is ideal for LPN/LVN and RN nursing students using the HESI as an exit or predictor exam. It works well for last-minute revision, remediation after practice exams, or as a comprehensive pharmacology refresher during the final stages of nursing school. The clear question-and-answer format makes it easy to study efficiently while focusing on the most testable and relevant pharmacology content.

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HESI Pharmacology
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Uploaded on
January 1, 2026
Number of pages
42
Written in
2025/2026
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Exam (elaborations)
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Questions & answers

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HESI PHARMACOLOGY EXIT EXAM
1. What is the indication for metoclopramide/reglan?

Answer Prevention of chemotherapy-induced emesis and diabetic gastroparesis

2. Side effects of metoclopramide/reglan

Answer Drowsiness, EPS such as tremors


3. Notify MD if what occurs when using metoclopramide/reglan

Answer Tremors


4. What is the indication xenical (orlistat, Alli)

Answer For PTs with BMI of 30+; LT weight control


5. SE of xenical (orlistat or alli)

Answer Oily stool and flatulence


6. Nursing implications for a pt on xenical (orlistat or alli)

Answer Ask pt to describe dietary intake since SE are increased if greater than 30% of fat is in diet.

7. What can decrease side effects of xenical (orlistat or alli)

Answer Fiber laxatives like Metamucil help decrease SE by binding to the fat.



,8. Which type of fluids need plenty of water?

Answer Bulk forming laxatives


9. Why do you need plenty of fluids when taking bulk forming laxatives

Answer Because they can produce esophageal and or intestinal obstruction

10. Laxative use assessment

Answer Last BM and characteristics, abdominal pain, fever and obstruction. Assess dietary and fluid intake.

11. With laxative use the nurse should

Answer Encourage fluids, fiber and exercise as tolerated/indicated


12. Laxative use and result in

Answer Lack of bowel tone which can lead to dependency


13. what is ondansetron (zofran)

Answer antiemetic


14. What is ondansetron (zofran)used for?

Answer Prevention of N/V associated with chemotherapy and radiation therapy.

15. Who should you use caution with when giving ondansetron/zofran?



,Answer PTs with liver failure

16. Drugs for ulcerative colitis and crohns

Answer 5 aminosalicylates; mesalamie, sulfasalazine.


17. How do 5 aminosalicylates; (mesalamie, sulfasalazine) work?

Answer They decrease GI inflammation

18. Side effects of 5 aminosalicylates; (mesalamie, sulfasalazine)

Answer Nausea, rash, arthral- gia, hematological disorders

19. Which drug can cause colitis/c.diff

Answer Linezolid/zyvox


20. What kind of infection is c.diff

Answer Suprainfection


21. What is azithromycin/zithromax?

Answer An antibiotic


22. What does azithromycin/zithromax treat?

Answer STDs such as



, gonorrhea and chlamydia


23. How much azithromycin/zithromax is usually required?

Answer One dose of 1g or 2g.
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