This A+ graded document contains 100+ expertly verified exam questions and answers covering the full spectrum of hepatology for students enrolled in MED335 – Hepatology and Liver Pathophysiology, designed for the 2025/2026 academic year. Each question is structured to reflect clinical vignettes, stepwise reasoning, and board-style exam expectations, making this an essential resource for high-stakes preparation.
Key topics include:
Cirrhosis & Liver Function: lab markers (e.g., thrombocytopenia, PT/albumin), hepatic encephalopathy, synthetic dysfunction, ascites, varices, and Milan criteria for liver transplant
Bilirubin Metabolism & Disorders: Crigler-Najjar, Gilbert's, Rotor, Dubin-Johnson syndromes
Pregnancy-Related Hepatic Conditions: HELLP, intrahepatic cholestasis of pregnancy
Viral Hepatitis: types A–E, serologic interpretation, vertical transmission risk, chronicity rates
Autoimmune, Metabolic & Genetic Liver Disorders: autoimmune hepatitis, hemochromatosis, Wilson’s disease, alpha-1 antitrypsin deficiency
Gallbladder and Biliary Disease: cholecystitis, Mirizzi syndrome, pigment stones, PSC vs PBC
Hepatic Neoplasms: cavernous hemangioma, hepatic adenoma, HCC, cholangiocarcinoma, FNH
Pharmacologic Hepatotoxicity: acetaminophen, anabolic steroids, drug-induced cholestasis
Additional clinical pearls include interpretation of hepatitis serologies, tumor markers (AFP, CA 19-9), portal hypertension complications, and criteria for diagnosing and managing spontaneous bacterial peritonitis (SBP).
Recommended for:
Medical students in gastroenterology, internal medicine, or pathophysiology blocks
Physician Assistant (PA), Nursing, and NP students in advanced medical training
USMLE Step 1/2, COMLEX, and MBBS exam candidates
IMGs and postgraduates preparing for hepatology boards or clinical rounds
Structured for clarity and mastery, this resource is both a study guide and a rapid-recall exam tool built around the most testable and clinically relevant concepts in liver medicine.
Keywords:
hepatology, MED335, cirrhosis, hepatitis B, hepatitis C, hepatic encephalopathy, bilirubin metabolism, Dubin-Johnson, Crigler-Najjar, HELLP syndrome, PBC, PSC, gallstones, hepatocellular carcinoma, hepatic adenoma, AFP, Wilson’s disease, hemochromatosis, liver transplant, Milan criteria, autoimmune hepatitis, SBP, drug-induced liver injury
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Hepatology Final Review 2025/2026
Exam Questions and Verified Answers |
Already Graded A+
What is the initial lab finding indicating Cirrhosis? - 🧠 ANSWER
✔✔Thrombocytopenia (platelets below 150,000)
You are palpating a patient's abdomen for hepatomegaly and determine
that the right lobe is elongated. You describe your finding as a "tongue-like
inferior projection of the right lobe of the liver". What is the name of your
finding? Is it considered an abnormal finding/positive for hepatomegaly? - 🧠
ANSWER ✔✔Reidel's lobe
No. Reidel's lob is a normal variant. Do not be fooled!!
,What is the major source of bilirubin? - 🧠 ANSWER ✔✔Senescent (old) red
blood cells
(Bilirubin is a breakdown product of heme & the majority of heme (70-90%)
comes from/is released from senescent RBCs)
What are the congenital conditions that result in conjugated
hyperbilirubinemia? - 🧠 ANSWER ✔✔Rotor's Syndrome & Dubin-Johnson
Syndrome
A woman has a baby diagnosed with Dubin-Johnson syndrome, what is the
prognosis? Treatment? - 🧠 ANSWER ✔✔The prognosis is great, no
treatment necessary, only intervention is to have the child avoid estrogens
when they are older
A pregnant woman is diagnosed with HELLP syndrome. What is your
recommendation regarding her delivery? - 🧠 ANSWER ✔✔Prompt delivery
is MANDATORY
Is PBC (primary biliary cirrhosis) more common in males or females? - 🧠
ANSWER ✔✔Females
, Is PSC (primary sclerosing cholangitis) more common in males or females?
- 🧠 ANSWER ✔✔Males
Which of the following is NOT a risk factor for developing gallstones?
A) Pregnancy
B) Estrogen use
C) Obesity
D) Rapid weight loss
E) Male gender - 🧠 ANSWER ✔✔E) Male gender
Females are more at risk for developing gallstones.
A chronic liver disease patient presents with the following manifestations:
arthralgias, glucose intolerance, hypogonadism, cardiomyopathy. What is
the most likely diagnosis? - 🧠 ANSWER ✔✔Hemochromatosis
A patient presents with isolated unconjugated hyperbilirubinemia of 2.1
(mild elevation). What is your diagnosis? - 🧠 ANSWER ✔✔Gilbert's
Syndrome
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