Keele University (KU) • Biochemistry and Human Biology

These notes cover: Calcium signalling pathways as a first, second and third messenger - including the function of SERCA pumps. Activation of RyR in skeletal and cardiac muscle Calmodulin signalling Calmodulin/ Calmodulin dependent kinase II pathway and Calcium-induced ion release mechanism These notes include annotated diagrams to illustrate pathways.

Notes which cover: Insulin secretion Insulin synthesis SNARE-mediated exocytosis Diseases which arise from glucose homeostasis dysfunction The notes are in colour and come with annotated diagrams and pictures. Clearly sectioned to help ease of learning.

These notes cover in detail: The structure of the retina The structure and function of cones and rod cells The structure of the eye in general The light transduction pathway The Retinol/ Rhodopsin cycle

These notes cover in detail: The structure and function of Phosphatidylinositides (including diagrams and pictures) The PI3K family The PI3K/Akt signalling pathway and its involvement in cancer therapy in detail. The IP3/DAG signalling pathway and its function The function of Phospholipase C The role of DAG The role of IP3 and the structure and function of Protein Kinase C

Notes cover information on: Glycosaminoglycan (GAG) Structure of Proteoglycans Composition of Heparan sulfate and Heparin Functions of proteoglycans

These notes cover information about: Structure of the Olfactory epithelium The Olfactory signaling pathway The structure of the olfactory bulb The different taste buds and their properties mechanisms of taste transduction for each type of receptor. includes annotated diagrams and pictures.

In-depth lecture notes covering all aspects of hormone signalling including: Growth hormone signalling. The role of the hypothalamus and the Pituitary gland in signalling pathways. Reproductive hormone cycles in males and females, Changes in the endocrine system during puberty, Endocrine control of growth, and Endocrine reproductive disorders. The notes include an annotated diagram of the endocrine system along with diagrams of pathways.