Board Certified Psychiatric Pharmacist (BCPP)
Practice Exam Verified Questions, Correct
Answers, and Detailed Explanations for Science
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1. Which neurotransmitter is most directly associated with the
positive symptoms of schizophrenia?
A. Serotonin
B. GABA
C. Glutamate
D. Dopamine
Answer: D
Excess dopamine activity in the mesolimbic pathway is linked to
hallucinations and delusions.
2. Which antipsychotic has the highest risk of agranulocytosis?
A. Risperidone
B. Olanzapine
C. Quetiapine
D. Clozapine
Answer: D
Clozapine uniquely carries a significant risk of agranulocytosis,
requiring REMS monitoring.
3. A patient stabilized on lithium develops tremor and polyuria.
Which serum level is most likely?
,A. 0.4 mEq/L
B. 0.6 mEq/L
C. 1.3 mEq/L
D. 0.2 mEq/L
Answer: C
Lithium levels above 1.2 mEq/L commonly cause dose-related adverse
effects.
4. Which antidepressant is contraindicated with linezolid?
A. Bupropion
B. Mirtazapine
C. Sertraline
D. Trazodone
Answer: C
Linezolid has MAOI activity, increasing the risk of serotonin syndrome
when combined with SSRIs.
5. Which mood stabilizer is most strongly associated with neural
tube defects?
A. Lithium
B. Carbamazepine
C. Valproic acid
D. Lamotrigine
Answer: C
Valproic acid has the highest teratogenic risk, especially neural tube
defects.
6. Which antipsychotic is most likely to cause hyperprolactinemia?
,A. Quetiapine
B. Clozapine
C. Risperidone
D. Aripiprazole
Answer: C
Risperidone strongly antagonizes D2 receptors, leading to elevated
prolactin.
7. Which antidepressant is preferred in patients with insomnia?
A. Fluoxetine
B. Bupropion
C. Trazodone
D. Venlafaxine
Answer: C
Trazodone’s sedating effects can improve sleep while treating
depression.
8. Which adverse effect is most associated with clozapine?
A. Akathisia
B. Tardive dyskinesia
C. Sialorrhea
D. Hyperprolactinemia
Answer: C
Clozapine commonly causes excessive salivation due to muscarinic
effects.
9. Which drug is FDA-approved for treatment-resistant depression?
, A. Fluoxetine
B. Esketamine
C. Duloxetine
D. Bupropion
Answer: B
Intranasal esketamine is approved for treatment-resistant
depression.
10. Which benzodiazepine has no active metabolites?
A. Diazepam
B. Chlordiazepoxide
C. Lorazepam
D. Clonazepam
Answer: C
Lorazepam undergoes direct glucuronidation, making it safer in
hepatic impairment.
11. Which antipsychotic has partial dopamine agonist activity?
A. Haloperidol
B. Risperidone
C. Aripiprazole
D. Olanzapine
Answer: C
Aripiprazole modulates dopamine activity rather than fully blocking
it.
12. Which SSRI has the longest half-life?
Practice Exam Verified Questions, Correct
Answers, and Detailed Explanations for Science
Students||Already Graded A+
1. Which neurotransmitter is most directly associated with the
positive symptoms of schizophrenia?
A. Serotonin
B. GABA
C. Glutamate
D. Dopamine
Answer: D
Excess dopamine activity in the mesolimbic pathway is linked to
hallucinations and delusions.
2. Which antipsychotic has the highest risk of agranulocytosis?
A. Risperidone
B. Olanzapine
C. Quetiapine
D. Clozapine
Answer: D
Clozapine uniquely carries a significant risk of agranulocytosis,
requiring REMS monitoring.
3. A patient stabilized on lithium develops tremor and polyuria.
Which serum level is most likely?
,A. 0.4 mEq/L
B. 0.6 mEq/L
C. 1.3 mEq/L
D. 0.2 mEq/L
Answer: C
Lithium levels above 1.2 mEq/L commonly cause dose-related adverse
effects.
4. Which antidepressant is contraindicated with linezolid?
A. Bupropion
B. Mirtazapine
C. Sertraline
D. Trazodone
Answer: C
Linezolid has MAOI activity, increasing the risk of serotonin syndrome
when combined with SSRIs.
5. Which mood stabilizer is most strongly associated with neural
tube defects?
A. Lithium
B. Carbamazepine
C. Valproic acid
D. Lamotrigine
Answer: C
Valproic acid has the highest teratogenic risk, especially neural tube
defects.
6. Which antipsychotic is most likely to cause hyperprolactinemia?
,A. Quetiapine
B. Clozapine
C. Risperidone
D. Aripiprazole
Answer: C
Risperidone strongly antagonizes D2 receptors, leading to elevated
prolactin.
7. Which antidepressant is preferred in patients with insomnia?
A. Fluoxetine
B. Bupropion
C. Trazodone
D. Venlafaxine
Answer: C
Trazodone’s sedating effects can improve sleep while treating
depression.
8. Which adverse effect is most associated with clozapine?
A. Akathisia
B. Tardive dyskinesia
C. Sialorrhea
D. Hyperprolactinemia
Answer: C
Clozapine commonly causes excessive salivation due to muscarinic
effects.
9. Which drug is FDA-approved for treatment-resistant depression?
, A. Fluoxetine
B. Esketamine
C. Duloxetine
D. Bupropion
Answer: B
Intranasal esketamine is approved for treatment-resistant
depression.
10. Which benzodiazepine has no active metabolites?
A. Diazepam
B. Chlordiazepoxide
C. Lorazepam
D. Clonazepam
Answer: C
Lorazepam undergoes direct glucuronidation, making it safer in
hepatic impairment.
11. Which antipsychotic has partial dopamine agonist activity?
A. Haloperidol
B. Risperidone
C. Aripiprazole
D. Olanzapine
Answer: C
Aripiprazole modulates dopamine activity rather than fully blocking
it.
12. Which SSRI has the longest half-life?
