Board Certified Oncology Pharmacist (BCOP)
Practice Exam Verified Questions, Correct
Answers, and Detailed Explanations for Science
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1. Which cytotoxic agent is classified as an alkylating-like agent but does not
contain an alkyl group?
A. Cyclophosphamide
B. Ifosfamide
C. Cisplatin
D. Melphalan
Answer: C. Cisplatin
Platinum agents form DNA crosslinks but are not true alkylators.
2. Which adverse effect is dose-limiting for doxorubicin?
A. Myelosuppression
B. Cardiotoxicity
C. Neurotoxicity
D. Nephrotoxicity
Answer: B. Cardiotoxicity
Anthracycline cardiomyopathy is cumulative and dose-limiting.
3. A patient receiving irinotecan develops early-onset diarrhea. Which
medication is most appropriate?
A. Loperamide
B. Atropine
C. Octreotide
D. Diphenoxylate
Answer: B. Atropine
Early diarrhea is cholinergic-mediated and treated with atropine.
,4. Tumor lysis syndrome is most commonly associated with which
malignancy?
A. Chronic lymphocytic leukemia
B. Multiple myeloma
C. Acute lymphoblastic leukemia
D. Solid tumors
Answer: C. Acute lymphoblastic leukemia
High tumor burden and rapid cell turnover increase TLS risk.
5. Which lab abnormality is NOT typical of tumor lysis syndrome?
A. Hyperkalemia
B. Hyperuricemia
C. Hypocalcemia
D. Hypernatremia
Answer: D. Hypernatremia
TLS causes phosphate and uric acid release, not sodium elevation.
6. Which agent is a monoclonal antibody targeting CD20?
A. Trastuzumab
B. Rituximab
C. Cetuximab
D. Bevacizumab
Answer: B. Rituximab
Rituximab targets CD20 on B lymphocytes.
7. Trastuzumab is primarily used in cancers overexpressing which receptor?
A. EGFR
B. HER2
C. VEGF
D. PD-1
, Answer: B. HER2
HER2 overexpression drives certain breast and gastric cancers.
8. Which chemotherapy agent commonly causes hemorrhagic cystitis?
A. Methotrexate
B. Cyclophosphamide
C. Vincristine
D. Bleomycin
Answer: B. Cyclophosphamide
Acrolein metabolite causes bladder toxicity.
9. Mesna is used to prevent toxicity from which chemotherapy agent?
A. Cisplatin
B. Methotrexate
C. Cyclophosphamide
D. Vinblastine
Answer: C. Cyclophosphamide
Mesna binds acrolein to prevent cystitis.
10. Which agent is associated with pulmonary fibrosis?
A. Bleomycin
B. Dactinomycin
C. Etoposide
D. Paclitaxel
Answer: A. Bleomycin
Bleomycin lung toxicity is dose-related.
11. Which antiemetic is a 5-HT3 receptor antagonist?
A. Metoclopramide
B. Aprepitant
Practice Exam Verified Questions, Correct
Answers, and Detailed Explanations for Science
Students||Already Graded A+
1. Which cytotoxic agent is classified as an alkylating-like agent but does not
contain an alkyl group?
A. Cyclophosphamide
B. Ifosfamide
C. Cisplatin
D. Melphalan
Answer: C. Cisplatin
Platinum agents form DNA crosslinks but are not true alkylators.
2. Which adverse effect is dose-limiting for doxorubicin?
A. Myelosuppression
B. Cardiotoxicity
C. Neurotoxicity
D. Nephrotoxicity
Answer: B. Cardiotoxicity
Anthracycline cardiomyopathy is cumulative and dose-limiting.
3. A patient receiving irinotecan develops early-onset diarrhea. Which
medication is most appropriate?
A. Loperamide
B. Atropine
C. Octreotide
D. Diphenoxylate
Answer: B. Atropine
Early diarrhea is cholinergic-mediated and treated with atropine.
,4. Tumor lysis syndrome is most commonly associated with which
malignancy?
A. Chronic lymphocytic leukemia
B. Multiple myeloma
C. Acute lymphoblastic leukemia
D. Solid tumors
Answer: C. Acute lymphoblastic leukemia
High tumor burden and rapid cell turnover increase TLS risk.
5. Which lab abnormality is NOT typical of tumor lysis syndrome?
A. Hyperkalemia
B. Hyperuricemia
C. Hypocalcemia
D. Hypernatremia
Answer: D. Hypernatremia
TLS causes phosphate and uric acid release, not sodium elevation.
6. Which agent is a monoclonal antibody targeting CD20?
A. Trastuzumab
B. Rituximab
C. Cetuximab
D. Bevacizumab
Answer: B. Rituximab
Rituximab targets CD20 on B lymphocytes.
7. Trastuzumab is primarily used in cancers overexpressing which receptor?
A. EGFR
B. HER2
C. VEGF
D. PD-1
, Answer: B. HER2
HER2 overexpression drives certain breast and gastric cancers.
8. Which chemotherapy agent commonly causes hemorrhagic cystitis?
A. Methotrexate
B. Cyclophosphamide
C. Vincristine
D. Bleomycin
Answer: B. Cyclophosphamide
Acrolein metabolite causes bladder toxicity.
9. Mesna is used to prevent toxicity from which chemotherapy agent?
A. Cisplatin
B. Methotrexate
C. Cyclophosphamide
D. Vinblastine
Answer: C. Cyclophosphamide
Mesna binds acrolein to prevent cystitis.
10. Which agent is associated with pulmonary fibrosis?
A. Bleomycin
B. Dactinomycin
C. Etoposide
D. Paclitaxel
Answer: A. Bleomycin
Bleomycin lung toxicity is dose-related.
11. Which antiemetic is a 5-HT3 receptor antagonist?
A. Metoclopramide
B. Aprepitant
