1|Page
Evolve Hesi Pharm Actual Exam Version 1,2,3 And
4 Newest 2026-2027 /Evolve Hesi Pharm Actual
Exam Practice Exam /Evolve Hesi Pharm Actual
Exam Preparation With Questions And Correct
Answers With Rationales| Already Graded A+
EVOLVE HESI PHARMACOLOGY VERSION 1
Which class of antineoplastic chemotherapy agents resembles the
essential elements required for DNA and RNA synthesis and inhibits
enzymes necessary for cellular function and replication?
A. Alkylating agents
B. Antimetabolites
C. Antitumor antibiotics
D. Plant alkaloids - CORRECT ANSWER-B. Antimetabolites
Rationale; Antimetabolites exert their action by inhibiting the enzymes
necessary for cellular function and replication. Options A, C, and D have
a different mechanism of action.
A child with cystic fibrosis is receiving ticarcillin disodium for
Pseudomonas pneumonia. For which adverse effect should the nurse
assess and report promptly to the health care provider?
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2|Page
A. Petechiae
B. Tinnitus
C. Oliguria
D. Hypertension - CORRECT ANSWER-A. Petechiae
Rationale; Adverse effects of ticarcillin disodium include
hypothrombinemia and decreased platelet adhesion, which can result in
the presence of petechiae. Options B, C, and D are not adverse effects
primarily associated with the administration of ticarcillin disodium.
A male client with prostatic carcinoma has arrived for his scheduled
dose of docetaxel chemotherapy. What symptom would indicate a need
for an immediate response by the nurse prior to implementing another
dose of this chemotherapeutic agent?
A. A cough that is new and persistent
B. Persistent nausea and vomiting
C. Fingernail and toenail changes
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D. Increasing weakness and neuropathy - CORRECT ANSWER-A. A
cough that is new and persistent
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Rationale; Option A is an adverse effect that is immediately life
threatening. Severe fluid retention can cause pleural effusion (requiring
urgent drainage), dyspnea at rest, cardiac tamponade, or pronounced
abdominal distention (caused by ascites). Options B, C, and D are all
adverse effects from chemotherapy and need to be monitored
consistently.
A 26-year-old primigravida client is experiencing increasing discomfort
and anxiety during the active phase of labor. She requests something for
pain. Which analgesic should the nurse anticipate administering?
A. Butorphanol
B. Hydromorphone
C. Morphine sulfate
D. Codeine sulfate - CORRECT ANSWER-A. Butorphanol
, 4|Page
Rationale; Butorphanol is a mixed agonist-antagonist analgesic resulting
in good analgesia but with less respiratory depression, nausea, and
vomiting compared with opioid agonist analgesics.
4|Page
Which question should the nurse ask a client prior to the initiation of
treatment with IV infusions of gentamicin sulfate?
A. "Are you having difficulty hearing?"
B. "Have you ever been diagnosed with cancer?"
C. "Do you have any type of diabetes mellitus?"
D. "Have you ever had anemia?" - CORRECT ANSWER-A. "Are you
having difficulty hearing?"
Rationale; Complications of gentamicin sulfate therapy include
ototoxicity, nephrotoxicity, and neurotoxicity. Determining if the client
is hard of hearing prior to initiation of this aminoglycoside will be
helpful as the treatment progresses and ototoxicity is identified as a
possible complication. Options B, C, and D are important elements of
any medical history, but they do not have the priority of option A when
assessing for complications of aminoglycoside therapy.
Evolve Hesi Pharm Actual Exam Version 1,2,3 And
4 Newest 2026-2027 /Evolve Hesi Pharm Actual
Exam Practice Exam /Evolve Hesi Pharm Actual
Exam Preparation With Questions And Correct
Answers With Rationales| Already Graded A+
EVOLVE HESI PHARMACOLOGY VERSION 1
Which class of antineoplastic chemotherapy agents resembles the
essential elements required for DNA and RNA synthesis and inhibits
enzymes necessary for cellular function and replication?
A. Alkylating agents
B. Antimetabolites
C. Antitumor antibiotics
D. Plant alkaloids - CORRECT ANSWER-B. Antimetabolites
Rationale; Antimetabolites exert their action by inhibiting the enzymes
necessary for cellular function and replication. Options A, C, and D have
a different mechanism of action.
A child with cystic fibrosis is receiving ticarcillin disodium for
Pseudomonas pneumonia. For which adverse effect should the nurse
assess and report promptly to the health care provider?
,2|Page
2|Page
A. Petechiae
B. Tinnitus
C. Oliguria
D. Hypertension - CORRECT ANSWER-A. Petechiae
Rationale; Adverse effects of ticarcillin disodium include
hypothrombinemia and decreased platelet adhesion, which can result in
the presence of petechiae. Options B, C, and D are not adverse effects
primarily associated with the administration of ticarcillin disodium.
A male client with prostatic carcinoma has arrived for his scheduled
dose of docetaxel chemotherapy. What symptom would indicate a need
for an immediate response by the nurse prior to implementing another
dose of this chemotherapeutic agent?
A. A cough that is new and persistent
B. Persistent nausea and vomiting
C. Fingernail and toenail changes
,3|Page
D. Increasing weakness and neuropathy - CORRECT ANSWER-A. A
cough that is new and persistent
3|Page
Rationale; Option A is an adverse effect that is immediately life
threatening. Severe fluid retention can cause pleural effusion (requiring
urgent drainage), dyspnea at rest, cardiac tamponade, or pronounced
abdominal distention (caused by ascites). Options B, C, and D are all
adverse effects from chemotherapy and need to be monitored
consistently.
A 26-year-old primigravida client is experiencing increasing discomfort
and anxiety during the active phase of labor. She requests something for
pain. Which analgesic should the nurse anticipate administering?
A. Butorphanol
B. Hydromorphone
C. Morphine sulfate
D. Codeine sulfate - CORRECT ANSWER-A. Butorphanol
, 4|Page
Rationale; Butorphanol is a mixed agonist-antagonist analgesic resulting
in good analgesia but with less respiratory depression, nausea, and
vomiting compared with opioid agonist analgesics.
4|Page
Which question should the nurse ask a client prior to the initiation of
treatment with IV infusions of gentamicin sulfate?
A. "Are you having difficulty hearing?"
B. "Have you ever been diagnosed with cancer?"
C. "Do you have any type of diabetes mellitus?"
D. "Have you ever had anemia?" - CORRECT ANSWER-A. "Are you
having difficulty hearing?"
Rationale; Complications of gentamicin sulfate therapy include
ototoxicity, nephrotoxicity, and neurotoxicity. Determining if the client
is hard of hearing prior to initiation of this aminoglycoside will be
helpful as the treatment progresses and ototoxicity is identified as a
possible complication. Options B, C, and D are important elements of
any medical history, but they do not have the priority of option A when
assessing for complications of aminoglycoside therapy.
