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NURS 611 Exam 1 (100 Questions) – Cell Injury, Fluid Balance, Electrolytes, Genetics – Maryville University

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This document includes 100 thoroughly solved questions from Exam 1 of NURS 611: Advanced Pathophysiology, prepared for the 2025/2026 academic year at Maryville University. It offers a detailed and structured review of critical topics that form the foundation of disease processes and clinical decision-making in advanced nursing education. Covered topics include apoptosis vs necrosis, ischemia and hypoxia, cell structures and organelles (nucleus, ribosomes, lysosomes, mitochondria, Golgi apparatus), membrane transport, energy metabolism (ATP production), free radicals and oxidative stress, and how chemical and radiation injuries affect cells. The document also reviews cellular adaptation (atrophy, hypertrophy, hyperplasia, metaplasia), aging effects on cells, and lysosomal degradation. Fluid and electrolyte balance is extensively covered, with in-depth explanations of sodium, potassium, calcium, phosphate, and magnesium imbalances, including clinical signs, causes, and pathophysiologic consequences of hypernatremia, hypokalemia, hypercalcemia, and others. Also discussed are fluid distribution, dehydration, hypovolemia, RAAS, ADH, and acid-base imbalances (including metabolic and respiratory acidosis/alkalosis). Genetic and epigenetic concepts are thoroughly reviewed, including aneuploidy (trisomy 21), penetrance, expressivity, autosomal dominant and recessive diseases (e.g., Huntington's, cystic fibrosis), BRCA genes, and epigenetic modifications influencing disease presentation in identical genotypes. This exam resource is ideal for: Nurse Practitioner (NP) students MSN and DNP candidates APRNs in training Students enrolled in graduate pathophysiology or medical genetics courses Allied health, PA, or pre-med students needing advanced foundational review Keywords: cell injury, apoptosis, necrosis, ischemia, hypoxia, free radicals, mitochondria, lysosomes, fluid balance, electrolytes, RAAS, ADH, hypernatremia, hypokalemia, hypercalcemia, acidosis, alkalosis, genetic disorders, trisomy 21, BRCA1, BRCA2, Huntington’s disease, cystic fibrosis, epigenetics, ATP metabolism, pathophysiology review, NURS 611, Maryville University

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Maryville NURS 611 Patho Exam 1
2025/2026 Exam Questions and Answers
| 100% Solved



Apoptosis - 🧠 ANSWER ✔✔A programmed cell death that is regulated or

programmed. Cellular self-destruction for elimination or unwanted cell

populations


Necrosis - 🧠 ANSWER ✔✔Rapid loss of the plasma membrane structure,

organelle swelling, mitochondria dysfunction

What is the #1 cause of cellular injury leading to necrosis (especially the

kidney and heart) - 🧠 ANSWER ✔✔hypoxia


What is the #1 cause of hypoxia? - 🧠 ANSWER ✔✔ischemia


Main component of a cell - 🧠 ANSWER ✔✔nucleus


What does the nucleus contain? - 🧠 ANSWER ✔✔nucleolus

,What is the nucleolus composed of? - 🧠 ANSWER ✔✔RNA, most of cellular

DNA, DNA binding proteins, and histones


Why are histone important? - 🧠 ANSWER ✔✔histones bind to DNA and fold

it into chromosomes (chromatin) which is essential for cell division


What are ribosomes? - 🧠 ANSWER ✔✔RNA-protein complexes

(nucleoproteins) that are synthesized in the nucleolus and secreted into the

cytoplasm through pores in the nuclear envelope called nuclear pore

complexes (NPCs)


Where can ribosomes be found? - 🧠 ANSWER ✔✔cytoplasm and rough ER


what are ribosomes chief function? - 🧠 ANSWER ✔✔provides sits for

cellular protein synthesis


What is the Golgi apparatus (complex)? - 🧠 ANSWER ✔✔a network of

flatten, smooth membranes and vesicles frequently located near the

nucleus of the cell


What does the Golgi apparatus do? - 🧠 ANSWER ✔✔takes proteins from

the ER and processes/packages them into small membrane-bound vesicles

called "secretory vesicles, and refines and directs traffic in the cell

, What are lysosomes and what do they do? - 🧠 ANSWER ✔✔maintain

cellular health by removal of toxic cellular components, removal of useless

organelles, termination of signal transduction, and signals cellular adaption


How does aging affect lysosomes? - 🧠 ANSWER ✔✔leads to progressive

loss of lysosomal efficiency which declines the regenerative capacity of

organs and tissue

What functions do lysosomal components integrate? - 🧠 ANSWER

✔✔nutrient abundance, energy levels, and cell stressors and will translate

them into instructions that regulate cellular metabolism toward either

proliferation or inactivity


What is mitochondria responsible for? - 🧠 ANSWER ✔✔cellular respiration,

cellular metabolism , and energy production

What does the inner membrane of mitochondria contain? - 🧠 ANSWER

✔✔enzymes of the respiratory chain and are essential to the process of

oxidative phosphorylation that generates most of the cell's ATP

The mitochondrial matrix contains what kind of pathways (1), involve what

two things (2), and metabolizes what three things (3)? - 🧠 ANSWER ✔✔1-

metabolic

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