NCLEX Style (G.I. Drugs) Questions
and Answers | Latest Version |
2025/2026 | Correct & Verified
Which class of drugs is commonly used to treat gastroesophageal reflux disease (GERD)?
A. Antiemetics
B. Laxatives
✔✔C. Proton Pump Inhibitors (PPIs)
D. Anticholinergics
What is the main action of omeprazole?
A. Neutralizes stomach acid
B. Increases gastric motility
✔✔C. Inhibits the proton pump to reduce acid secretion
D. Coats the stomach lining
Which adverse effect is most concerning for long-term PPI therapy?
A. Constipation
B. Headache
1
,✔✔C. Increased risk of fractures and hypomagnesemia
D. Diarrhea
Which medication combination is commonly used to treat H. pylori infection?
A. Omeprazole + magnesium hydroxide
✔✔B. Omeprazole + antibiotics (clarithromycin + amoxicillin)
C. Ranitidine + docusate sodium
D. Sucralfate + metoclopramide
What is the primary action of antacids like calcium carbonate?
✔✔Neutralize existing stomach acid
A. Block H2 receptors
B. Reduce motility
C. Form a protective barrier
Which drug protects ulcer sites by coating the stomach lining?
A. Omeprazole
✔✔B. Sucralfate
2
,C. Metoclopramide
D. Aluminum hydroxide
What is a priority nursing consideration when administering sucralfate?
✔✔Give on an empty stomach and separate from other medications
A. Administer with meals
B. Give at the same time as antacids
C. Avoid giving with water
Which drug increases gastric motility to treat GERD or gastroparesis?
A. Omeprazole
✔✔B. Metoclopramide
C. Sucralfate
D. Ranitidine
Which adverse effect is associated with metoclopramide?
A. Constipation
✔✔B. Extrapyramidal symptoms
3
, C. Hypertension
D. Hypoglycemia
Which class of drugs blocks dopamine receptors to control nausea?
A. Antacids
✔✔B. Dopamine antagonists
C. Proton Pump Inhibitors
D. H2 blockers
Which drug provides rapid relief of heartburn by neutralizing stomach acid?
✔✔Antacids (e.g., magnesium hydroxide)
A. Omeprazole
B. Metoclopramide
C. Sucralfate
Which H2 receptor antagonist reduces gastric acid secretion?
A. Omeprazole
✔✔B. Ranitidine (or famotidine)
4
and Answers | Latest Version |
2025/2026 | Correct & Verified
Which class of drugs is commonly used to treat gastroesophageal reflux disease (GERD)?
A. Antiemetics
B. Laxatives
✔✔C. Proton Pump Inhibitors (PPIs)
D. Anticholinergics
What is the main action of omeprazole?
A. Neutralizes stomach acid
B. Increases gastric motility
✔✔C. Inhibits the proton pump to reduce acid secretion
D. Coats the stomach lining
Which adverse effect is most concerning for long-term PPI therapy?
A. Constipation
B. Headache
1
,✔✔C. Increased risk of fractures and hypomagnesemia
D. Diarrhea
Which medication combination is commonly used to treat H. pylori infection?
A. Omeprazole + magnesium hydroxide
✔✔B. Omeprazole + antibiotics (clarithromycin + amoxicillin)
C. Ranitidine + docusate sodium
D. Sucralfate + metoclopramide
What is the primary action of antacids like calcium carbonate?
✔✔Neutralize existing stomach acid
A. Block H2 receptors
B. Reduce motility
C. Form a protective barrier
Which drug protects ulcer sites by coating the stomach lining?
A. Omeprazole
✔✔B. Sucralfate
2
,C. Metoclopramide
D. Aluminum hydroxide
What is a priority nursing consideration when administering sucralfate?
✔✔Give on an empty stomach and separate from other medications
A. Administer with meals
B. Give at the same time as antacids
C. Avoid giving with water
Which drug increases gastric motility to treat GERD or gastroparesis?
A. Omeprazole
✔✔B. Metoclopramide
C. Sucralfate
D. Ranitidine
Which adverse effect is associated with metoclopramide?
A. Constipation
✔✔B. Extrapyramidal symptoms
3
, C. Hypertension
D. Hypoglycemia
Which class of drugs blocks dopamine receptors to control nausea?
A. Antacids
✔✔B. Dopamine antagonists
C. Proton Pump Inhibitors
D. H2 blockers
Which drug provides rapid relief of heartburn by neutralizing stomach acid?
✔✔Antacids (e.g., magnesium hydroxide)
A. Omeprazole
B. Metoclopramide
C. Sucralfate
Which H2 receptor antagonist reduces gastric acid secretion?
A. Omeprazole
✔✔B. Ranitidine (or famotidine)
4
