Nclex style: Pharmacokinetics,
Pharmacodynamics, and
Pharmacogenetics Questions and
Answers | Latest Version | 2025/2026 |
Correct & Verified
Which phase of pharmacokinetics describes the movement of a drug from the site of
administration into the bloodstream?
A. Distribution
B. Metabolism
✔✔C. Absorption
D. Excretion
What term describes the process by which a drug is transformed into a more water-soluble form
for elimination?
A. Absorption
✔✔B. Metabolism
C. Distribution
D. Excretion
1
,Which organ is primarily responsible for metabolizing most medications?
A. Kidney
✔✔B. Liver
C. Lungs
D. Spleen
What does the half-life of a drug indicate?
A. Time to peak plasma concentration
B. Duration of therapeutic effect
✔✔C. Time for the plasma concentration to decrease by 50%
D. Onset of action
Which route of administration avoids first-pass metabolism?
A. Oral
✔✔B. Sublingual
C. Enteral
D. Rectal
2
,What is the term for the movement of a drug from the bloodstream into tissues and organs?
A. Absorption
✔✔B. Distribution
C. Metabolism
D. Elimination
Which plasma protein binds most drugs in circulation?
✔✔A. Albumin
B. Globulin
C. Fibrinogen
D. Hemoglobin
What pharmacodynamic property describes the maximum effect a drug can produce?
A. Potency
✔✔B. Efficacy
C. Bioavailability
D. Half-life
3
, What is the term for the amount of drug that reaches systemic circulation after administration?
A. Clearance
B. Half-life
✔✔C. Bioavailability
D. Volume of distribution
Which pharmacokinetic process is most affected by renal impairment?
A. Absorption
B. Distribution
C. Metabolism
✔✔D. Excretion
What does pharmacogenetics study?
A. Drug absorption rates
B. Drug interactions
✔✔C. How genetic differences affect individual drug responses
D. Drug elimination
4
Pharmacodynamics, and
Pharmacogenetics Questions and
Answers | Latest Version | 2025/2026 |
Correct & Verified
Which phase of pharmacokinetics describes the movement of a drug from the site of
administration into the bloodstream?
A. Distribution
B. Metabolism
✔✔C. Absorption
D. Excretion
What term describes the process by which a drug is transformed into a more water-soluble form
for elimination?
A. Absorption
✔✔B. Metabolism
C. Distribution
D. Excretion
1
,Which organ is primarily responsible for metabolizing most medications?
A. Kidney
✔✔B. Liver
C. Lungs
D. Spleen
What does the half-life of a drug indicate?
A. Time to peak plasma concentration
B. Duration of therapeutic effect
✔✔C. Time for the plasma concentration to decrease by 50%
D. Onset of action
Which route of administration avoids first-pass metabolism?
A. Oral
✔✔B. Sublingual
C. Enteral
D. Rectal
2
,What is the term for the movement of a drug from the bloodstream into tissues and organs?
A. Absorption
✔✔B. Distribution
C. Metabolism
D. Elimination
Which plasma protein binds most drugs in circulation?
✔✔A. Albumin
B. Globulin
C. Fibrinogen
D. Hemoglobin
What pharmacodynamic property describes the maximum effect a drug can produce?
A. Potency
✔✔B. Efficacy
C. Bioavailability
D. Half-life
3
, What is the term for the amount of drug that reaches systemic circulation after administration?
A. Clearance
B. Half-life
✔✔C. Bioavailability
D. Volume of distribution
Which pharmacokinetic process is most affected by renal impairment?
A. Absorption
B. Distribution
C. Metabolism
✔✔D. Excretion
What does pharmacogenetics study?
A. Drug absorption rates
B. Drug interactions
✔✔C. How genetic differences affect individual drug responses
D. Drug elimination
4
