Maryville Pharmacology Exam 1
COMPREHENSIVE QUESTIONS AND VERIFIED
ANSWERS (DETAILED & ELABORATED) ACTUAL
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1. define the pt's problem
2. Specify therapeutic objectives
What are the 5 WHO 3. choose which drug or treatment is needed
prescribing guidelines? 4. Write the Rx and start tx
5. Educate and counsel the pt
6. monitor effect of treatment
Define the pt's problem . This forms the basis for
choosing and rx-ing the correct treatment.
WHO rx guideline 1 Consultation should include: complaints, symptoms,
diagnosis and relevant characteristics like co-
morbidities, co-medication, pregnancy, drug allergies
Specify the therapeutic objective. What needs to be
WHO rx guideline 2
treated?
3a. select the p-drug (prescribers personal drug of
first choice for the indication.)
WHO rx guideline 3 3b. Is the p-drug appropriate? checking for
contraindications, interactions, pregnancy, allergies,
etc.
WHO rx guideline 4 Write rx and start the treatment.
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Educate and counsel the pt. Intructions and warnings
WHO rx guideline 5
about the tx.
WHO rx 6 Monitor the treatment.
*beta blocker used to treat mild to severe CHF, left
ventricular dysfunction following MI, HTN.
*works by causing vasodilation to the peripheral
vasculature to decrease the workload on the heart.
*Non selective beta blocker and Alpha-1 blocker
Coreg (Carvedilol) *3rd generation beta blocker
*particularly useful in African Americans
*Dose: 0.625 mg-25mg PO BID with food
*administering with food helps prevent postural
hypotension
*Education: don't skip doses, take with food
1. A-allergic
hypersensitivty reactions: 2.C-cytotoxic
mnemonic ACID 3.I- Immune complex deposition
4. D-delayed
A-allergic
*IgE mediated- quick onset after exposure
Type I hypersensitivity
*production of IgE after antigen exposure.
*urticaria, wheezing, rhinitis, anaphylaxis
C-cytotoxic
*cytotoxic/antibody mediated
* drug binds to RBCs and is recognized by antibody-
Type II hypersensitivity
usually IgG
*complement and cytotoxic T cells are activated
*Rare response
I-immune complex/IgG/IgM mediated
*antibodies are formed against soluble antigens.
Type III hypersensitivity ANtigen-antibody complexes are deposited in tissues
such as joints and lungs.
*cause serum sickness. Ex: ceclor (antibiotic)
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, 5/6/25, 9:07 AM Maryville Pharmacology Exam 1 COMPREHENSIVE QUESTIONS AND VERIFIED ANSWERS (DETAILED & ELABORATED) ACTU…
D-delayed- delayed or cell mediated
*cytotoxic T cells are activated
Type IV hypersensitivity *poison ivy, latex, etc
*causes contact dermatitis
*cytokine storm if there is repeated exposure
*increases drug toxicity
*don't drink with SSRIs, calcium channel blockers,
Grapefruit juice
statins, benzos
*increases absorption and decreases the metabolism
*anticholinergic
Atropine-class/mechanism *inhibits action of acetylcholine and blocks the PNS.
of action *Increases HR by increasing conduction int eh SA and
AV node
*symptomatic bradycardia (sinus, junctional, AV
blocks, causing significant hypotension, ventricular
ectopy, angina, etc.)
atropine- indications
*organphosphate poisoning
* RSI in peds
*beta blocker and calcium channel blocker overdose
*tachycardia
atropine- *HTN
contraindications *hypothermic bradycardia
*narrow angle glaucoma
drowsiness, confusion, HA, tachycardia, palpitations,
atropine adverse reactions dysrhythmias, N/V, paradoxical bradycardia if pushed
too slowly or given in low doses
Pregnancy category C
atropine special
paradoxical bradycardia can occur with doses lower
considerations to know
than 0.1 mg.
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