Chapter 07: Methods of Calculation for Individualized Drug Dosing
Kee: Clinical Calculations: With Applications to General and Specialty Areas, 9th
Edition
OTHER
Body Surface Area by Square Root
1. Order: cyclophosphamide 500 mg/m2 in 500 mL of normal saline solution (NSS) over 90
minutes
Patient height and weight: 5 ft 10 in, 142 lb
Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20
mg/mL
a. What is the patient’s body surface area (BSA) (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a.
b. 500 mg/m2 1.78 m2 = 890 mg
c. FE: 890 mg/100 mg 5 mL = 44.5 mL
OR
2. Order: cisplatin 50 mg/m2 in 500 mL of NSS intravenously over 90 minutes
Patient height and weight: 5 ft 6 in, 160 lb
Drug available: cisplatin 100 mg/100 mL
a. What is the patient’s BSA (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a.
b. 50 mg 1.84 m2 = 92 mg
c. FE: 92 mg/100 mg 100 mL = 92 mL
OR
,3. For the following questions, use the square root method and/or nomogram. Note
discrepancies between methods.
Give dacarbazine 250 mg/m2/day 5 days.
Patient height: 5 ft 10 in
Patient weight: 173 lb
What is the daily dose with
a. square root method?
b. nomogram?
ANS:
a.
250 mg/m2/day 1.97 m2 = 493 mg/day
b. Height 70 in, weight 173 lb, intersects 2.02 m2
250 mg/m2/day 2.02 m2 = 505 500 mg/day
,4. For the following questions, use the square root method and/or nomogram. Note
discrepancies between methods.
Give 5-fluorouracil 450 mg/m2/wk.
Patient height: 5 ft 6 in
Patient weight: 210 lb
What is the weekly dose with
a. square root method?
b. nomogram?
ANS:
a.
450 mg/m2/wk 2.10 m2 = 945 mg/wk
b. Height 66 in, weight 210 lb, intersects 2.04 m2
450 mg/m2/wk 2.04 m2 = 918 920 mg/wk
, 5. For the following questions, use the square root method and/or nomogram. Note
discrepancies between methods.
Give leucovorin 200 mg/m2/wk.
Patient height: 5 ft 6 in
Patient weight: 210 lb
What is the weekly dose with
a. square root method?
b. nomogram?
ANS:
a.
200 mg/m2/wk 2.10 m2 = 420 mg/wk
b. Height 66 in, weight 210 lb, intersects 2.04 m2
200 mg/m2/wk 2.04 m2 = 408.00 400 mg/wk
Kee: Clinical Calculations: With Applications to General and Specialty Areas, 9th
Edition
OTHER
Body Surface Area by Square Root
1. Order: cyclophosphamide 500 mg/m2 in 500 mL of normal saline solution (NSS) over 90
minutes
Patient height and weight: 5 ft 10 in, 142 lb
Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20
mg/mL
a. What is the patient’s body surface area (BSA) (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a.
b. 500 mg/m2 1.78 m2 = 890 mg
c. FE: 890 mg/100 mg 5 mL = 44.5 mL
OR
2. Order: cisplatin 50 mg/m2 in 500 mL of NSS intravenously over 90 minutes
Patient height and weight: 5 ft 6 in, 160 lb
Drug available: cisplatin 100 mg/100 mL
a. What is the patient’s BSA (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?
ANS:
a.
b. 50 mg 1.84 m2 = 92 mg
c. FE: 92 mg/100 mg 100 mL = 92 mL
OR
,3. For the following questions, use the square root method and/or nomogram. Note
discrepancies between methods.
Give dacarbazine 250 mg/m2/day 5 days.
Patient height: 5 ft 10 in
Patient weight: 173 lb
What is the daily dose with
a. square root method?
b. nomogram?
ANS:
a.
250 mg/m2/day 1.97 m2 = 493 mg/day
b. Height 70 in, weight 173 lb, intersects 2.02 m2
250 mg/m2/day 2.02 m2 = 505 500 mg/day
,4. For the following questions, use the square root method and/or nomogram. Note
discrepancies between methods.
Give 5-fluorouracil 450 mg/m2/wk.
Patient height: 5 ft 6 in
Patient weight: 210 lb
What is the weekly dose with
a. square root method?
b. nomogram?
ANS:
a.
450 mg/m2/wk 2.10 m2 = 945 mg/wk
b. Height 66 in, weight 210 lb, intersects 2.04 m2
450 mg/m2/wk 2.04 m2 = 918 920 mg/wk
, 5. For the following questions, use the square root method and/or nomogram. Note
discrepancies between methods.
Give leucovorin 200 mg/m2/wk.
Patient height: 5 ft 6 in
Patient weight: 210 lb
What is the weekly dose with
a. square root method?
b. nomogram?
ANS:
a.
200 mg/m2/wk 2.10 m2 = 420 mg/wk
b. Height 66 in, weight 210 lb, intersects 2.04 m2
200 mg/m2/wk 2.04 m2 = 408.00 400 mg/wk
