NURS 8024 Pharm Exam 3 (antimicrobial part 2)fully solved

NURS 8024 Pharm Exam 3 (antimicrobial
part 2)

Bacterial protein synthesis inhibitors - correct answer ✔✔Clindamycin



Clindamycin - correct answer ✔✔Time dependent killing

Inhibits protein synthesis

Bacteriostatic

90% bioavailability



Clindamycin mechanism of resistance - correct answer ✔✔Altered target sites

Active efflux (pushes drug out of the cell)



Clindamycin ADE - correct answer ✔✔GI upset

Skin rash

Neutropenia

Superinfections such a c diff pseudomembranous

- don't use if patient has history of c diff



Clindamycin indications - correct answer ✔✔Gram positive

Prophylaxis of endocarditis in valve patients with PCN allergy



Oxazolidinones - correct answer ✔✔New class of bacterial protein synthesis inhibitors



Time dependent killing

Prevents formation of ribosome complex

Bacteriostatic & Bactericidal against strep

, Linezolid - correct answer ✔✔Protein synthesis inhibitor

100% bioavailability orally

30% CSF penetration



Linezolid ADE - correct answer ✔✔Hematologic

Increased thrombocytopenia risk

Anemia, neutropenia, neuropathy

Optic & peripheral neuropathy

Serotonin syndrome with SSRIs



Linezolid Indications - correct answer ✔✔Gram positive resistant

VRE, HCAP, CAP

Complicated skin & tissue infections

Off label use for TB

No resistance currently



Fluoroquinolones - correct answer ✔✔Norfloxacin (1st gen)

Ciprofloxacin & Ofloxacin (2nd gen)

Levofloxacin (3rd gen)

Moxifloxacin & Gemifloxacin (3rd gen respiratory)



Fluoroquinolones are classified by - correct answer ✔✔Generations according to antimicrobial spectra



1st Generation Fluoroquinolone - correct answer ✔✔Narrow gram negative

Norfloxacin



2nd Generation Fluoroquinolone - correct answer ✔✔Broad- gram negative and gram positive

Cipro & ofloxacin