LE 9 – Immunotherapy
December 15 th , 2023
The role of immunotherapy in oncology
The cancer immunogram
,Somatic mutations across cancer types
More mutations = more immune recognition = more intervention of immune system.
▪ Low registration of checkpoint inhibitors means that the prevalence of somatic mutations is
low.
Aim: Durable tumor responses
Targeted therapy works for the short term (up to 1 year), whereas the survival rate at the long term is
better.
Immune checkpoint inhibitors
T-cell activation
3 signals
1. Antigen
2. Co-stimulation form antigen presenting cell
(APC)
3. Cytokines
, Ipilimumab blocks negative signaling of CTLA-4
Immune checkpoint blockade: anti-CTLA-4 mAb
December 15 th , 2023
The role of immunotherapy in oncology
The cancer immunogram
,Somatic mutations across cancer types
More mutations = more immune recognition = more intervention of immune system.
▪ Low registration of checkpoint inhibitors means that the prevalence of somatic mutations is
low.
Aim: Durable tumor responses
Targeted therapy works for the short term (up to 1 year), whereas the survival rate at the long term is
better.
Immune checkpoint inhibitors
T-cell activation
3 signals
1. Antigen
2. Co-stimulation form antigen presenting cell
(APC)
3. Cytokines
, Ipilimumab blocks negative signaling of CTLA-4
Immune checkpoint blockade: anti-CTLA-4 mAb
