L15 – The TCA Cycle
Slide 3 – Alternative names for pathway
• Krebs cycle
• Citric acid cycle
• Tricarboxylic acid cycle
• Common terminal pathway
Slide 4 – Catabolism of sugars, fats and amino acids in 3 stages
Slide 5 – Key points
• Definition: oxidation of acetyl CoA to carbon dioxide and water
• Location: mitochondrial matrix
• Tissues: all tissues with mitochondria (not RBCs and or white muscle fibres)
• Functions: energy trapping, biosynthesis of intermediates
Slide 6-8 – Summary of TCA events
, Describe the reaction catalysed by pyruvate dehydrogenase for the conversion of
pyruvate of acetyl CoA
Slide 9 – Conversion of pyruvate to acetyl CoA (link reaction)
• Pyruvate + coenzyme A with thiol group --> acetyl CoA + carbon dioxide
• Oxidative decarboxylation: oxidation reaction where we are also removing a carbon
• Reducing NAD+, making NADH and H+
Slide 3 – Alternative names for pathway
• Krebs cycle
• Citric acid cycle
• Tricarboxylic acid cycle
• Common terminal pathway
Slide 4 – Catabolism of sugars, fats and amino acids in 3 stages
Slide 5 – Key points
• Definition: oxidation of acetyl CoA to carbon dioxide and water
• Location: mitochondrial matrix
• Tissues: all tissues with mitochondria (not RBCs and or white muscle fibres)
• Functions: energy trapping, biosynthesis of intermediates
Slide 6-8 – Summary of TCA events
, Describe the reaction catalysed by pyruvate dehydrogenase for the conversion of
pyruvate of acetyl CoA
Slide 9 – Conversion of pyruvate to acetyl CoA (link reaction)
• Pyruvate + coenzyme A with thiol group --> acetyl CoA + carbon dioxide
• Oxidative decarboxylation: oxidation reaction where we are also removing a carbon
• Reducing NAD+, making NADH and H+
